Pirbuterol is no longer marketed in the US. Although no published data exist on the use of pirbuterol by mouth or inhaler during lactation, data from the related drug, terbutaline, indicate that very little is expected to be excreted into breastmilk.[1] The authors of several reviews and an expert panel agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.[2-4]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Boréus LO, de Château P, Lindberg C, Nyberg L. Terbutaline in breast milk. Br J Clin Pharmacol 1982;13:731-2. [PMC free article: PMC1402089] [PubMed: 7082542]
2.
McDonald CF, Burdon JGW. Asthma in pregnancy and lactation. A position paper for the Thoracic Society of Australia and New Zealand. Med J Aust 1996;165:485-8. [PubMed: 8937369]
3.
Nelson-Piercy C. Asthma in pregnancy. Thorax 2001;56:325-8. [PMC free article: PMC1746013] [PubMed: 11254828]
4.
National Heart, Lung, and Blood, Institute, National Asthma, Education, and, Prevention, Program, Asthma, and, Pregnancy, Working, Group. NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. J Allergy Clin Immunol 2005;115:34-46. [PubMed: 15637545]
Substance Identification
Substance Name
Pirbuterol
CAS Registry Number
38677-81-5
Drug Class
Breast Feeding
Lactation
Milk, Human
Anti-Asthmatic Agents
Bronchodilator Agents
Beta Adrenergic Agonists
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