Perindopril Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 22, 2023.

Applies to perindopril: oral tablet.

Serious side effects of Perindopril

Along with its needed effects, perindopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking perindopril:

More common

• Body aches or pain
• chills
• cough
• difficulty breathing
• ear congestion
• fever
• headache
• loss of voice
• nasal congestion
• runny nose
• sneezing
• sore throat
• unusual tiredness or weakness

Less common

• Bladder pain
• bloody or cloudy urine
• change in hearing
• chest pain
• cold
• congestion
• diarrhea
• difficult, burning, or painful urination
• dryness of the throat
• earache or pain in the ear
• ear drainage
• frequent urge to urinate
• general feeling of discomfort or illness
• hoarseness
• joint pain
• loss of appetite
• lower back or side pain
• nausea
• shivering
• stomach pain
• swelling
• tender, swollen glands in the neck
• trouble sleeping
• trouble with swallowing
• voice changes
• vomiting

Rare

• Blurred vision
• confusion
• decreased urination
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• irregular heartbeat
• muscle cramps or pain
• numbness, tingling, pain, or weakness in the hands or feet
• rapid breathing
• seizures
• sunken eyes
• sweating
• thirst
• trembling
• weakness and heaviness of the legs

Other side effects of Perindopril

Some side effects of perindopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Back pain
• lack or loss of strength
• pain or tenderness around the eyes and cheekbones
• tightness of the chest

Less common

• Belching
• bloated feeling
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• diarrhea
• difficulty moving
• discouragement
• excess air or gas in the stomach or intestines
• feeling of fullness
• feeling sad or empty
• hearing loss
• injury
• irritability
• leg pain
• loss of interest or pleasure
• muscle ache, stiffness, tension, or tightness
• neck pain
• nervousness
• pain, swelling, or redness in the joints
• passing of gas
• rash
• sleepiness or unusual drowsiness
• stomach discomfort or upset
• swollen joints
• trouble concentrating

For Healthcare Professionals

Applies to perindopril: oral tablet.

General

The most common adverse events were cough, dizziness, and back pain.^[Ref]

Respiratory

Very common (10% or more): Cough (up to 12%)

Common (1% to 10%): Dyspnea, epistaxis

Uncommon (0.1% to 1%): Bronchospasm

Very rare (less than 0.01%): Eosinophilic pneumonia, rhinitis^[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, vertigo, tinnitus, dysgeusia, drowsiness

Uncommon (0.1% to 1%): Somnolence, syncope

Very rare (less than 0.01%): Stroke^[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting

Uncommon (0.1% to 1%): Dry mouth

Very rare (less than 0.01%): Pancreatitis

Postmarketing reports: Acute pancreatitis^[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, palpitations, vasculitis, flushing, impaired peripheral circulation

Uncommon (0.1% to 1%): Tachycardia

Rare (0.01% to 0.1%): Sudden cardiac arrest

Very rare (less than 0.01%): Angina pectoris, arrhythmia, myocardial infarction^[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Urticaria, angioedema, photosensitivity reactions, pemphigoid, hyperhidrosis, eczema, sweating

Very rare (less than 0.01%): Erythema multiforme

Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis^[Ref]

Other

Common (1% to 10%): Asthenia, discomfort on exertion

Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain

Postmarketing reports: Serositis^[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramps, back pain

Uncommon (0.1% to 1%): Arthralgia, myalgia^[Ref]

Hepatic

Common (1% to 10%): ALT increased

Uncommon (0.1% to 1%): AST increased

Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased

Very rare (less than 0.01%): Hepatitis

Postmarketing reports: Hepatic failure, jaundice^[Ref]

Ocular

Common (1% to 10%): Visual disturbances^[Ref]

Renal

Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased

Very rare (less than 0.01%): Acute renal failure

Postmarketing reports: Nephritis^[Ref]

Metabolic

Uncommon (0.1% to 1%): Hypoglycemia, hyperkalemia, hyponatremia

Postmarketing reports: Symptomatic hyponatremia^[Ref]

Hematologic

Uncommon (0.1% to 1%): Eosinophilia, leukopenia/neutropenia

Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio

Postmarketing reports: Anemia, leukocytosis, elevated erythrocyte sedimentation rate^[Ref]

Psychiatric

Uncommon (0.1% to 1%): Mood disturbances, sleep disorder

Very rare (less than 0.01%): Confusion, depression, hallucinations^[Ref]

Genitourinary

Uncommon (0.1% to 1%): Erectile dysfunction^[Ref]

Immunologic

Postmarketing reports: Positive antinuclear antibody^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer