Perindopril Side Effects
Medically reviewed by Drugs.com. Last updated on May 17, 2020.
Commonly reported side effects of perindopril include: cough. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to perindopril: oral tablet
Oral route (Tablet)
Stop perindopril as soon as possible when pregnancy is detected. Medications acting directly on the renin-angiotensin system can cause injury or death to the developing fetus.
Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
fever, chills, body aches, flu symptoms, sores in your mouth and throat;
little or no urination;
swelling, rapid weight gain;
high potassium--nausea, slow or unusual heart rate, weakness, loss of movement;
pale skin, easy bruising or bleeding; or
jaundice (yellowing of the skin or eyes).
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
For Healthcare Professionals
Applies to perindopril: oral tablet
The most common adverse events were cough, dizziness, and back pain.[Ref]
Very common (10% or more): Cough (up to 12%)
Common (1% to 10%): Dyspnea, epistaxis
Uncommon (0.1% to 1%): Bronchospasm
Uncommon (0.1% to 1%): Somnolence, syncope
Very rare (less than 0.01%): Stroke[Ref]
Uncommon (0.1% to 1%): Dry mouth
Very rare (less than 0.01%): Pancreatitis
Postmarketing reports: Acute pancreatitis[Ref]
Uncommon (0.1% to 1%): Tachycardia
Rare (0.01% to 0.1%): Sudden cardiac arrest
Common (1% to 10%): Pruritus, rash
Very rare (less than 0.01%): Erythema multiforme
Common (1% to 10%): Asthenia, discomfort on exertion
Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain
Postmarketing reports: Serositis[Ref]
Common (1% to 10%): Muscle cramps, back pain
Uncommon (0.1% to 1%): Arthralgia, myalgia[Ref]
Common (1% to 10%): ALT increased
Uncommon (0.1% to 1%): AST increased
Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased
Very rare (less than 0.01%): Hepatitis
Common (1% to 10%): Visual disturbances[Ref]
Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased
Very rare (less than 0.01%): Acute renal failure
Postmarketing reports: Nephritis[Ref]
Postmarketing reports: Symptomatic hyponatremia[Ref]
Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio
Uncommon (0.1% to 1%): Mood disturbances, sleep disorder
Postmarketing reports: Positive antinuclear antibody[Ref]
1. "Product Information. Aceon (perindopril)." Solvay Pharmaceuticals Inc, Marietta, GA.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
More about perindopril
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 28 Reviews
- Drug class: Angiotensin Converting Enzyme Inhibitors
- FDA Alerts (1)
- Other brands
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.