Perindopril Side Effects

In Summary

Commonly reported side effects of perindopril include: cough. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to perindopril: oral tablet

As well as its needed effects, perindopril may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking perindopril, check with your doctor immediately:

• Body aches or pain
• chills
• cough
• difficulty breathing
• ear congestion
• fever
• headache
• loss of voice
• nasal congestion
• runny nose
• sneezing
• sore throat
• unusual tiredness or weakness

• Abdominal or stomach pain
• bladder pain
• bloody or cloudy urine
• change in hearing
• chest pain
• cold or flu-like symptoms
• congestion
• difficult, burning, or painful urination
• dryness of the throat
• earache or pain in the ear
• ear drainage
• frequent urge to urinate
• hoarseness
• lower back or side pain
• swelling
• tender, swollen glands in the neck
• trouble with swallowing
• voice changes
• vomiting

• Blurred vision
• confusion
• decreased urination
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• irregular heartbeat
• muscle cramps or pain
• numbness, tingling, pain, or weakness in the hands or feet
• rapid breathing
• seizures
• sunken eyes
• sweating
• thirst
• trembling
• weakness and heaviness of the legs

Minor Side Effects

Some perindopril side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

• Back pain
• lack or loss of strength
• pain or tenderness around the eyes and cheekbones
• tightness of the chest

• Belching
• bloated
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• diarrhea
• difficulty moving
• discouragement
• excess air or gas in the stomach or intestines
• feeling sad or empty
• full feeling
• hearing loss
• injury
• irritability
• lack of appetite
• leg pain
• loss of interest or pleasure
• muscle aching, stiffness, tension, or tightness
• nausea
• neck pain
• nervousness
• pain, swelling, or redness in the joints
• passing gas
• rash
• sleepiness or unusual drowsiness
• stomach discomfort or upset
• swollen joints
• trouble concentrating
• trouble sleeping

For Healthcare Professionals

Applies to perindopril: oral tablet

General

The most common adverse events were cough, dizziness, and back pain.^[Ref]

Respiratory

Very common (10% or more): Cough (up to 12%)
Common (1% to 10%): Dyspnea, epistaxis
Uncommon (0.1% to 1%): Bronchospasm
Very rare (less than 0.01%): Eosinophilic pneumonia, rhinitis^[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, vertigo, tinnitus, dysgeusia, drowsiness
Uncommon (0.1% to 1%): Somnolence, syncope
Very rare (less than 0.01%): Stroke^[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting
Uncommon (0.1% to 1%): Dry mouth
Very rare (less than 0.01%): Pancreatitis
Postmarketing reports: Acute pancreatitis^[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, palpitations, vasculitis, flushing, impaired peripheral circulation
Uncommon (0.1% to 1%): Tachycardia
Rare (0.01% to 0.1%): Sudden cardiac arrest
Very rare (less than 0.01%): Angina pectoris, arrhythmia, myocardial infarction^[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Urticaria, angioedema, photosensitivity reactions, pemphigoid, hyperhidrosis, eczema, sweating
Very rare (less than 0.01%): Erythema multiforme
Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis^[Ref]

Other

Common (1% to 10%): Asthenia, discomfort on exertion
Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain
Postmarketing reports: Serositis^[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramps, back pain
Uncommon (0.1% to 1%): Arthralgia, myalgia^[Ref]

Hepatic

Common (1% to 10%): ALT increased
Uncommon (0.1% to 1%): AST increased
Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased
Very rare (less than 0.01%): Hepatitis
Postmarketing reports: Hepatic failure, jaundice^[Ref]

Ocular

Common (1% to 10%): Visual disturbances^[Ref]

Renal

Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased
Very rare (less than 0.01%): Acute renal failure
Postmarketing reports: Nephritis^[Ref]

Metabolic

Uncommon (0.1% to 1%): Hypoglycemia, hyperkalemia, hyponatremia
Postmarketing reports: Symptomatic hyponatremia^[Ref]

Hematologic

Uncommon (0.1% to 1%): Eosinophilia, leukopenia/neutropenia
Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio
Postmarketing reports: Anemia, leukocytosis, elevated erythrocyte sedimentation rate^[Ref]

Psychiatric

Uncommon (0.1% to 1%): Mood disturbances, sleep disorder
Very rare (less than 0.01%): Confusion, depression, hallucinations^[Ref]

Genitourinary

Uncommon (0.1% to 1%): Erectile dysfunction^[Ref]

Immunologic

Postmarketing reports: Positive antinuclear antibody^[Ref]

It is possible that some side effects of perindopril may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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