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Perindopril Side Effects

Medically reviewed by Drugs.com. Last updated on May 17, 2020.

In Summary

Commonly reported side effects of perindopril include: cough. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to perindopril: oral tablet

Warning

Oral route (Tablet)

Stop perindopril as soon as possible when pregnancy is detected. Medications acting directly on the renin-angiotensin system can cause injury or death to the developing fetus.

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  • little or no urination;

  • swelling, rapid weight gain;

  • high potassium--nausea, slow or unusual heart rate, weakness, loss of movement;

  • pale skin, easy bruising or bleeding; or

  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Healthcare Professionals

Applies to perindopril: oral tablet

General

The most common adverse events were cough, dizziness, and back pain.[Ref]

Respiratory

Very common (10% or more): Cough (up to 12%)

Common (1% to 10%): Dyspnea, epistaxis

Uncommon (0.1% to 1%): Bronchospasm

Very rare (less than 0.01%): Eosinophilic pneumonia, rhinitis[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, vertigo, tinnitus, dysgeusia, drowsiness

Uncommon (0.1% to 1%): Somnolence, syncope

Very rare (less than 0.01%): Stroke[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting

Uncommon (0.1% to 1%): Dry mouth

Very rare (less than 0.01%): Pancreatitis

Postmarketing reports: Acute pancreatitis[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, palpitations, vasculitis, flushing, impaired peripheral circulation

Uncommon (0.1% to 1%): Tachycardia

Rare (0.01% to 0.1%): Sudden cardiac arrest

Very rare (less than 0.01%): Angina pectoris, arrhythmia, myocardial infarction[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Urticaria, angioedema, photosensitivity reactions, pemphigoid, hyperhidrosis, eczema, sweating

Very rare (less than 0.01%): Erythema multiforme

Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis[Ref]

Other

Common (1% to 10%): Asthenia, discomfort on exertion

Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain

Postmarketing reports: Serositis[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramps, back pain

Uncommon (0.1% to 1%): Arthralgia, myalgia[Ref]

Hepatic

Common (1% to 10%): ALT increased

Uncommon (0.1% to 1%): AST increased

Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased

Very rare (less than 0.01%): Hepatitis

Postmarketing reports: Hepatic failure, jaundice[Ref]

Ocular

Common (1% to 10%): Visual disturbances[Ref]

Renal

Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased

Very rare (less than 0.01%): Acute renal failure

Postmarketing reports: Nephritis[Ref]

Metabolic

Uncommon (0.1% to 1%): Hypoglycemia, hyperkalemia, hyponatremia

Postmarketing reports: Symptomatic hyponatremia[Ref]

Hematologic

Uncommon (0.1% to 1%): Eosinophilia, leukopenia/neutropenia

Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio

Postmarketing reports: Anemia, leukocytosis, elevated erythrocyte sedimentation rate[Ref]

Psychiatric

Uncommon (0.1% to 1%): Mood disturbances, sleep disorder

Very rare (less than 0.01%): Confusion, depression, hallucinations[Ref]

Genitourinary

Uncommon (0.1% to 1%): Erectile dysfunction[Ref]

Immunologic

Postmarketing reports: Positive antinuclear antibody[Ref]

References

1. "Product Information. Aceon (perindopril)." Solvay Pharmaceuticals Inc, Marietta, GA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.