Penetrex Side Effects
Generic Name: enoxacin
Note: This page contains side effects data for the generic drug enoxacin. It is possible that some of the dosage forms included below may not apply to the brand name Penetrex.
Applies to enoxacin: oral tablet
Enoxacin (the active ingredient contained in Penetrex) therapy is generally well tolerated, and adverse effects are mild in nature. Discontinuation of therapy due to adverse effects occurs in approximately 3% of patients.[Ref]
Gastrointestinal disturbances due to enoxacin (the active ingredient contained in Penetrex) therapy may occur in up to 9% of patients. This most frequently includes nausea, abdominal pain, anorexia, dyspepsia, and diarrhea. Enoxacin therapy has resulted in pseudomembranous colitis although it has minimal effect on the anaerobic flora of the GI tract.[Ref]
Nervous system adverse effects occur in approximately 2% to 3% of patients. These most commonly include headache, dizziness, fatigue, nervousness, agitation, and insomnia. Seizures have also been reported in susceptible patients.[Ref]
Hypersensitivity reactions resulting in rash and pruritus have been reported in up to 1% of patients treated with enoxacin (the active ingredient contained in Penetrex) Photosensitivity can occur. Erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson Syndrome have also been reported.[Ref]
Asymptomatic elevations in hepatic transaminases have been reported in less than 1% of patients treated with enoxacin (the active ingredient contained in Penetrex) Cholestatic jaundice has been reported in one patient shortly after enoxacin administration.[Ref]
Hematologic abnormalities such as eosinophilia and leukopenia occur in less than 1% of enoxacin-treated patients.[Ref]
Arthralgias and myalgias occur rarely.[Ref]
Tachycardia and facial flushing have been reported rarely.[Ref]
Women treated with enoxacin (the active ingredient contained in Penetrex) may experience vaginal pruritus and vaginitis.[Ref]
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2. Foot M, Williams G, Want S, et al "An open study of the safety and efficacy of enoxacin in complicated urinary tract infections." J Antimicrob Chemother 21 (1988): 97-103
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8. "Product Information. Penetrex (enoxacin)." Rhone-Poulenc Rorer, Collegeville, PA.
9. Just PM "Overview of the fluoroquinolone antibiotics." Pharmacotherapy 13 (1993): s4-17
10. Edlund C, Lidbeck A, Kager L, Nord CE "Comparative effects of enoxacin and norfloxacin on human colonic microflora." Antimicrob Agents Chemother 31 (1987): 1846-8
11. Tsuei SE, Darragh AS, Brick I "Pharmacokinetics and tolerance of enoxacin in healthy volunteers administered at a dosage of 400 mg twice daily for 14 days." J Antimicrob Chemother 14 (1984): 71-4
12. Kang JS, Kim TH, Park KB, Chung BH, Youn JI "Enoxacin photosensitivity." Photodermatol Photoimmunol Photomed 9 (1993): 159-61
13. Kawabe Y, Mizuno N, Sakakibara S "Photoallergic reaction caused by enoxacin." Photodermatol 6 (1989): 58-60
14. Petri H, Tronnier H "Efficacy of enoxacin in the treatment of bacterial infections of the skin with regards to photosensitization." Infection 14 (1986): s213-16
15. Amitrano L, Gigliotti T, Guardascione MA, Ascione A "Acute cholestatic liver injury induced by enoxacin." J Hepatol 18 (1993): 139-40
It is possible that some side effects of Penetrex may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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