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Olopatadine nasal Side Effects

Medically reviewed by Last updated on Apr 12, 2022.


Commonly reported side effects of olopatadine nasal include: epistaxis. Other side effects include: nasal mucosa ulcer. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olopatadine nasal: nasal spray

Side effects requiring immediate medical attention

Along with its needed effects, olopatadine nasal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olopatadine nasal:

Less common

  • Bladder pain
  • bloody nose
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • sore throat


  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Difficulty with breathing or swallowing
  • dizziness
  • fast heartbeat
  • shortness of breath
  • skin itching, rash, or redness
  • swelling of the face, throat, or tongue
  • unpleasant breath odor
  • vomiting of blood

Get emergency help immediately if any of the following symptoms of overdose occur while taking olopatadine nasal:

Symptoms of overdose

  • Anxiety
  • deep or fast breathing with dizziness
  • dry mouth
  • irregular heartbeats
  • irritability
  • nervousness
  • numbness of the feet, hands, and around the mouth
  • restlessness
  • shaking
  • sleepiness

Side effects not requiring immediate medical attention

Some side effects of olopatadine nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bitter taste


  • Throat irritation

Incidence not known

  • Thirst

For Healthcare Professionals

Applies to olopatadine nasal: nasal spray


The most frequently reported side effects were bitter taste, headache, epistaxis, pharyngolaryngeal pain, postnasal drip, cough, urinary tract infection, pyrexia, and rash.[Ref]


Very common (10% or more): Epistaxis (up to 25%), nasal ulceration (up to 10%)

Common (1% to 10%): Pharyngolaryngeal pain, postnasal drip, cough, upper respiratory tract infection

Uncommon (0.1% to 1%): Nasopharyngitis, throat irritation

Postmarketing reports: Nasal discomfort, oropharyngeal pain[Ref]

Nervous system

Very common (10% or more): Taste bitter (up to 12.8%)

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Somnolence

Frequency not reported: Hyposmia, anosmia

Postmarketing reports: Dizziness, dysgeusia[Ref]


Common (1% to 10%): Rash[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Pyrexia

Uncommon (0.1% to 1%): Creatine phosphokinase elevated, fatigue, influenza[Ref]


Uncommon (0.1% to 1%): Dry mouth[Ref]


Frequency not reported: Depression/depression worsened[Ref]


1. "Product Information. Patanase (olopatadine nasal)." Alcon Laboratories Inc (2008):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.