Skip to Content

Olopatadine nasal Side Effects

In Summary

Commonly reported side effects of olopatadine nasal include: epistaxis. Other side effects include: nasal mucosa ulcer. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olopatadine nasal: nasal spray

Along with its needed effects, olopatadine nasal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olopatadine nasal:

Less common
  • Bladder pain
  • bloody nose
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • sore throat
Rare Incidence not known
  • Difficulty with breathing or swallowing
  • dizziness
  • fast heartbeat
  • shortness of breath
  • skin itching, rash, or redness
  • swelling of the face, throat, or tongue
  • unpleasant breath odor
  • vomiting of blood

Get emergency help immediately if any of the following symptoms of overdose occur while taking olopatadine nasal:

Symptoms of overdose
  • Anxiety
  • deep or fast breathing with dizziness
  • dry mouth
  • irregular heartbeats
  • irritability
  • nervousness
  • numbness of the feet, hands, and around the mouth
  • restlessness
  • shaking
  • sleepiness

Some side effects of olopatadine nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bitter taste
  • Throat irritation
Incidence not known
  • Thirst

For Healthcare Professionals

Applies to olopatadine nasal: nasal spray


The most frequently reported side effects were bitter taste, headache, epistaxis, pharyngolaryngeal pain, postnasal drip, cough, urinary tract infection, pyrexia, and rash.[Ref]


Very common (10% or more): Epistaxis (up to 25%), nasal ulceration (up to 10%)
Common (1% to 10%): Pharyngolaryngeal pain, postnasal drip, cough, upper respiratory tract infection
Uncommon (0.1% to 1%): Nasopharyngitis, throat irritation
Postmarketing reports: Nasal discomfort, oropharyngeal pain[Ref]

Nervous system

Very common (10% or more): Taste bitter (up to 12.8%)
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Somnolence
Frequency not reported: Hyposmia, anosmia
Postmarketing reports: Dizziness, dysgeusia[Ref]


Common (1% to 10%): Rash[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Pyrexia
Uncommon (0.1% to 1%): Creatine phosphokinase elevated, fatigue, influenza[Ref]


Uncommon (0.1% to 1%): Dry mouth[Ref]


Frequency not reported: Depression/depression worsened[Ref]


1. "Product Information. Patanase (olopatadine nasal)." Alcon Laboratories Inc, Fort Worth, TX.

Some side effects of olopatadine nasal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.