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Olopatadine nasal Side Effects

In Summary

Commonly reported side effects of olopatadine nasal include: epistaxis. Other side effects include: nasal mucosa ulcer. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olopatadine nasal: nasal spray

As well as its needed effects, olopatadine nasal may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking olopatadine nasal, check with your doctor immediately:

Less common:
  • Bladder pain
  • bloody nose
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • sore throat
  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Incidence not known:
  • Difficulty with breathing or swallowing
  • dizziness
  • fast heartbeat
  • shortness of breath
  • skin itching, rash, or redness
  • swelling of the face, throat, or tongue
  • unpleasant breath odor
  • vomiting of blood

If any of the following symptoms of overdose occur while taking olopatadine nasal, get emergency help immediately:

Symptoms of overdose:
  • Anxiety
  • deep or fast breathing with dizziness
  • dry mouth
  • irregular heartbeats
  • irritability
  • nervousness
  • numbness of the feet, hands, and around the mouth
  • restlessness
  • shaking
  • sleepiness

Minor Side Effects

Some olopatadine nasal side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Bitter taste
  • Throat irritation
Incidence not known:
  • Thirst

For Healthcare Professionals

Applies to olopatadine nasal: nasal spray


The most frequently reported side effects were bitter taste, headache, epistaxis, pharyngolaryngeal pain, postnasal drip, cough, urinary tract infection, pyrexia, and rash.[Ref]


Very common (10% or more): Epistaxis (up to 25%), nasal ulceration (up to 10%)
Common (1% to 10%): Pharyngolaryngeal pain, postnasal drip, cough, upper respiratory tract infection
Uncommon (0.1% to 1%): Nasopharyngitis, throat irritation
Postmarketing reports: Nasal discomfort, oropharyngeal pain[Ref]

Nervous system

Very common (10% or more): Taste bitter (up to 12.8%)
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Somnolence
Frequency not reported: Hyposmia, anosmia
Postmarketing reports: Dizziness, dysgeusia[Ref]


Common (1% to 10%): Rash[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Pyrexia
Uncommon (0.1% to 1%): Creatine phosphokinase elevated, fatigue, influenza[Ref]


Uncommon (0.1% to 1%): Dry mouth[Ref]


Frequency not reported: Depression/depression worsened[Ref]


1. "Product Information. Patanase (olopatadine nasal)." Alcon Laboratories Inc, Fort Worth, TX.

It is possible that some side effects of olopatadine nasal may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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