Skip to Content

Olopatadine nasal Side Effects

In Summary

Commonly reported side effects of olopatadine nasal include: epistaxis. Other side effects include: nasal mucosa ulcer. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olopatadine nasal: nasal spray

As well as its needed effects, olopatadine nasal may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking olopatadine nasal, check with your doctor immediately:

Less common:
  • Bladder pain
  • bloody nose
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • sore throat
  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Incidence not known:
  • Difficulty with breathing or swallowing
  • dizziness
  • fast heartbeat
  • shortness of breath
  • skin itching, rash, or redness
  • swelling of the face, throat, or tongue
  • unpleasant breath odor
  • vomiting of blood

If any of the following symptoms of overdose occur while taking olopatadine nasal, get emergency help immediately:

Symptoms of overdose:
  • Anxiety
  • deep or fast breathing with dizziness
  • dry mouth
  • irregular heartbeats
  • irritability
  • nervousness
  • numbness of the feet, hands, and around the mouth
  • restlessness
  • shaking
  • sleepiness

Minor Side Effects

Some olopatadine nasal side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Bitter taste
  • Throat irritation
Incidence not known:
  • Thirst

For Healthcare Professionals

Applies to olopatadine nasal: nasal spray


Gastrointestinal side effects have included bitter taste, dry mouth, nasopharyngitis, and pharyngolaryngeal pain. Post marketing reports have included dysgeusia, hyposmia and anosmia.[Ref]


Respiratory side effects have included epistaxis, cough, and postnasal drip. Nasal septal perforation has also been reported. Post Marketing reports have included nasal discomfort and oropharyngeal pain[Ref]


Genitourinary side effects have included urinary tract infection.[Ref]

Nervous system

Nervous system side effects have included somnolence. Post marketing reports have included dizziness and headache.[Ref]


Other side effects have included influenza.[Ref]


Psychiatric side effects have included depression or worsening of depression.[Ref]


1. "Product Information. Patanase (olopatadine nasal)." Alcon Laboratories Inc, Fort Worth, TX.

It is possible that some side effects of olopatadine nasal may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.