Nateglinide Side Effects
Medically reviewed by Drugs.com. Last updated on May 10, 2020.
For the Consumer
Applies to nateglinide: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, nateglinide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking nateglinide:
Less common
- Convulsions (seizures)
- unconsciousness
Check with your doctor as soon as possible if any of the following side effects occur while taking nateglinide:
Less common
- Low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness
Incidence not known-occurred during clinical practice
Side effects not requiring immediate medical attention
Some side effects of nateglinide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Cough
- runny or stuffy nose
- sore throat
Less common
- Abdominal or stomach pain
- back pain
- chills
- dizziness
- pain in joints or muscles
- sneezing
- swelling in joints
For Healthcare Professionals
Applies to nateglinide: oral tablet
General
The most frequently reported adverse events included upper respiratory tract infections and symptoms of hypoglycemia.[Ref]
Metabolic
Common (1% to 10%): Hypoglycemia
Frequency not reported: Increases in mean uric acid level[Ref]
Hypoglycemia has been reported and has generally been mild and corrected by intake of carbohydrates. In comparative clinical trials, hypoglycemia was reported in 10.4%, 14.5%, 6.9%, 19.8%, and 4.1% in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, and placebo, respectively.
Mean uric acid levels were increased in patient receiving this drug as monotherapy. The difference from placebo in treated patients was 0.29 mg/dL, 0.45 mg/dL, 0.28 mg/dL, and 0.19 mg/dL in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, respectively. The clinical significance of these findings is unknown.[Ref]
Respiratory
Common (1% to 10%): Upper respiratory tract infection, bronchitis, coughing[Ref]
Hypersensitivity
Postmarketing reports: Hypersensitivity reactions such as rash, itching, and urticaria[Ref]
Gastrointestinal
Common (1% to 10%): Diarrhea, abdominal pain, dyspepsia, nausea
Uncommon (0.1% to 1%): Vomiting[Ref]
Gastrointestinal symptoms, especially diarrhea and nausea, were no more common in patients using this drug in combination with metformin than in patients receiving metformin alone.[Ref]
Hepatic
Postmarketing reports: Elevated liver enzymes, jaundice, cholestatic hepatitis[Ref]
Nervous system
Common (1% to 10%): Dizziness[Ref]
Musculoskeletal
Common (1% to 10%): Back pain, arthropathy[Ref]
Cardiovascular
Frequency not reported: Peripheral edema[Ref]
Peripheral edema was no more common in patients using this drug in combination with rosiglitazone than in patients receiving rosiglitazone alone.[Ref]
Dermatologic
Postmarketing reports: Erythema multiforme[Ref]
Immunologic
Common (1% to 10%): Flu symptoms[Ref]
Other
Common (1% to 10%): Accidental trauma[Ref]
References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Starlix (nateglinide)" Novartis Pharmaceuticals, East Hanover, NJ.
3. Cerner Multum, Inc. "Australian Product Information." O 0
More about nateglinide
- During Pregnancy or Breastfeeding
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- Drug Interactions
- Pricing & Coupons
- En Español
- 4 Reviews
- Drug class: meglitinides
Consumer resources
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- Starlix
Professional resources
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.