Motpoly XR Side Effects

Generic name: lacosamide

Medically reviewed by Drugs.com. Last updated on Jan 27, 2025.

Note: This document provides detailed information about Motpoly XR Side Effects associated with lacosamide. Some dosage forms listed on this page may not apply specifically to the brand name Motpoly XR.

Applies to lacosamide: oral capsule extended release, oral solution, oral tablet.

Other dosage forms:

• intravenous solution

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

If you or your child develop any unusual or strange thoughts and behavior while taking lacosamide (the active ingredient contained in Motpoly XR) be sure to discuss it with your doctor. Some changes that have occurred in people taking this medicine are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

This medicine may cause blurred vision, double vision, clumsiness, unsteadiness, dizziness, drowsiness, sleepiness, or trouble with thinking. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. If these side effects are especially bothersome, check with your doctor.

This medicine can cause changes in heart rhythms, including a condition called PR prolongation. It may change the way your heart beats and cause lightheadedness, fainting, or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, including a fast, slow, or irregular heartbeat.

Do not Stop taking lacosamide without first checking with your doctor. Stopping the medicine suddenly may cause your seizures to return or to occur more often. Your doctor may want you to gradually reduce the amount you are using before stopping it completely.

Lacosamide may cause a condition called drug reaction with eosinophilia and systemic symptoms (DRESS), which is a serious allergic reaction affecting multiple body organs (eg, liver or kidney). Check with your doctor right away if you have fever, dark urine, headache, rash, stomach pain, swollen, painful, or tender lymph glands in the neck, armpit, or groin, unusual tiredness, or yellow eyes or skin.

Breastfeeding during treatment with this medicine may cause your baby to be more sleepy. Talk with your doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Motpoly XR

Along with its needed effects, lacosamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lacosamide:

Other side effects of Motpoly XR

Some side effects of lacosamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to lacosamide: intravenous solution, oral capsule extended release, oral solution, oral tablet.

General adverse events

The most commonly reported adverse reactions have included diplopia, headache, dizziness, and nausea.

Nervous system

• Very common (10% or more): Dizziness (up to 60%), headache (up to 13%), ataxia (up to 15%)
• Common (1% to 10%): Somnolence, tremor, balance disorder, nystagmus, memory impairment, coordination abnormal, cognitive disorder, somnolence, tremor, dysarthria, disturbance in attention, paresthesia
• Frequency not reported: Oral hypoesthesia, pyrexia
• Postmarketing reports: Hypoesthesia, cerebellar syndrome, new or worsening seizures, dyskinesia^[Ref]

Dizziness was reported in 25% of patients randomized to the recommended doses (200 to 400 mg/day) of this drug compared with 8% of placebo patients in studies in adult patients with partial-onset seizures taking 1 to 3 concomitant AEDs. It was the event most frequently leading to discontinuation (3%). Ataxia was reported by 6% of patients randomized to the recommended doses (200 to 400 mg/day) compared to 2% in placebo patients. Dizziness and ataxia were also observed in pediatric clinical trials.^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 24%), vomiting (up to 16%)
• Common (1% to 10%): Diarrhea, constipation, flatulence, dyspepsia, dry mouth^[Ref]

Ocular

• Very common (10% or more): Diplopia (up to 16%), blurred vision (up to 16%)^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity
• Frequency not reported: Multiorgan hypersensitivity reactions (also known as Drug Reaction with Eosinophilia and Systemic Symptoms, or DRESS)^[Ref]

Other

• Very common (10% or more): Fatigue (up to 15%)
• Common (1% to 10%): Asthenia, vertigo, gait disturbance
• Frequency not reported: Tinnitus, fall^[Ref]

Local

• Common (1% to 10%): Injection site pain or discomfort
• Uncommon (0.1% to 1%): Irritation, erythema^[Ref]

Psychiatric

• Common (1% to 10%): Depression, confusional state, insomnia
• Uncommon (0.1% to 1%): Aggression, agitation, euphoric mood, suicide attempt, suicidal ideation, hallucination
• Frequency not reported: Irritability, feeling drunk
• Postmarketing reports: Psychotic disorder^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Uncommon (0.1% to 1%): Angioedema, urticaria
• Frequency not reported: Neutropenia, anemia
• Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis^[Ref]

Cardiovascular

• Very common (10% or more): Chest pain (up to 12%)
• Common (1% to 10%): Syncope
• Uncommon (0.1% to 1%): Atrioventricular block, bradycardia, atrial fibrillation, atrial flutter
• Frequency not reported: Palpitations
• Postmarketing reports: Cardiac arrhythmias including bradycardia, AV block, and ventricular tachyarrhythmia, which have rarely resulted in asystole, cardiac arrest, and death^[Ref]

During clinical trials in adult patients with partial-onset seizures, asymptomatic first-degree atrioventricular (AV) block was observed in 0.4% (4/944) of patients randomized to this drug and 0% (0/364) of placebo patients. One case of profound bradycardia was observed in a patient during a 15-minute 150 mg IV infusion.

In short-term trials in adult patients with diabetic neuropathy, atrial fibrillation occurred in 0.5% of patients (placebo=0%). Syncope occurred in 1.2% of patients (placebo=0%).

A clinical pharmacology study in healthy subjects (n=247) did not shown any QTc interval prolongation or dose-related or clinically important effects on QRS duration. This drug did produce a dose-related increase in mean PR interval; the maximum mean PR interval increase corresponded with Tmax. The placebo-subtracted maximum increase in PR interval was 7.3 ms for the 400 mg/day group and 11.9 ms for the 800 mg/day group. In clinical trials, the placebo-subtracted mean maximum increase in PR interval for a 400 mg/day dose was 3.1 ms in patients with partial-onset seizures and 9.4 ms for patients with diabetic neuropathy.^[Ref]

Musculoskeletal

• Common (1% to 10%): Muscle spasms
• Frequency not reported: Connective tissue disorders^[Ref]

Hematologic

• Frequency not reported: Neutropenia, anemia
• Postmarketing reports: Agranulocytosis^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Liver function test abnormal
• Frequency not reported: Hepatitis^[Ref]

See also:

Further information

Motpoly XR side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer