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Monopril Side Effects

Generic Name: fosinopril

Note: This document contains side effect information about fosinopril. Some of the dosage forms listed on this page may not apply to the brand name Monopril.

For the Consumer

Applies to fosinopril: oral tablet

Along with its needed effects, fosinopril (the active ingredient contained in Monopril) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fosinopril:

Less common
  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fast, slow, or irregular heartbeat
  • pounding or rapid pulse
  • sweating
  • unusual tiredness or weakness

Some side effects of fosinopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Cough
Less common

For Healthcare Professionals

Applies to fosinopril: oral tablet


Adverse events were generally mild and transient, and their frequency was not prominently related to dose within the recommended daily dosage range.[Ref]


Common (1% to 10%): Rash, angioedema, dermatitis
Uncommon (0.1% to 1%): Urticaria, photosensitivity, pruritus, excessive sweating/hyperhidrosis
Rare (less than 0.1%): Ecchymosis
Frequency not reported: Bullous pemphigus, exfoliative dermatitis[Ref]


Common (1% to 10%): Orthostatic hypotension, angina pectoris, hypotension, atrial/cardiac rhythm disturbances, tachycardia
Uncommon (0.1% to 1%): Myocardial infarction, hypertensive crisis, palpitations, flushing, claudication, cardiorespiratory arrest, shock, non-anginal chest pain, hypertension, conduction disorder, bradycardia, cardiac arrest, conduction disturbances, transitory ischemia
Rare (less than 0.1%): Hemorrhage, peripheral vascular disease
Frequency not reported: Vasculitis[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 11.9%)
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Tremor, paresthesia, drowsiness, cerebrovascular accident, syncope, memory disturbance, taste disturbance/dysgeusia, cerebral infarction, transient ischemic attack (TIA), numbness, somnolence, stroke
Rare (less than 0.1%): Dysphasia[Ref]


Common (1% to 10%): Cough, dyspnea, upper respiratory infection
Uncommon (0.1% to 1%): Bronchospasm, pharyngitis, sinusitis, rhinitis, laryngitis/hoarseness, epistaxis, abnormal vocalization, sinus abnormality, abnormal breathing, pleuritic chest pain, tracheobronchitis
Rare (less than 0.1%): Pneumonia, pulmonary congestion
Frequency not reported: Eosinophilic pneumonitis[Ref]


Common (1% to 10%): Nausea, vomiting, diarrhea, abdominal pain
Uncommon (0.1% to 1%): Pancreatitis, dysphagia, abdominal distention, flatulence, constipation, heartburn, appetite changes, dry mouth
Rare (0.01% to 0.1%): Oral lesions, swollen tongue
Very rare (less than 0.01%): Intestinal angioedema, sub-ileus[Ref]


Common (1% to 10%): Elevated alkaline phosphatase, elevated lactate dehydrogenase
Uncommon (0.1% to 1%): Gout, hyperkalemia, increased blood urea, decreased appetite, weight increase
Rare (less than 0.1%): Hyponatremia
Frequency not reported: Symptomatic hyponatremia[Ref]


Uncommon (0.1% to 1%): Renal insufficiency, kidney pain, renal failure, increased serum creatinine
Very rare (less than 0.01%): Acute renal failure
Frequency not reported: Elevated BUN[Ref]


Common (1% to 10%): Increased serum bilirubin, elevated transaminases
Uncommon (0.1% to 1%): Hepatitis, hepatomegaly
Very rare (less than 0.01%): Hepatic failure
Frequency not reported: Hepatocellular jaundice, cholestatic jaundice[Ref]


Common (1% to 10%): Sexual dysfunction
Uncommon (0.1% to 1%): Urinary frequency, abnormal urination, proteinuria
Rare (less than 0.1%): Prostatic disorders[Ref]


Uncommon (0.1% to 1%): Lymphadenopathy, transient decreased hemoglobin, decreased hematocrit
Rare (0.01% to 0.1%): Eosinophilia, leukopenia, neutropenia, thrombocytopenia, transient anemia
Very rare (less than 0.01%): Agranulocytosis
Frequency not reported: pancytopenia, hemolytic anemia, aplastic anemia, leukocytosis, elevated erythrocyte sedimentation rate (ESR)[Ref]


Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Mood change, decreased libido, confusion, sleep disturbance, depression, behavior change
Rare (less than 0.1%): Disorientation[Ref]


Common (1% to 10%): Muscle cramp, musculoskeletal pain
Uncommon (0.1% to 1%): Arthralgia, myalgia, muscle ache, weakness of an extremity
Rare (less than 0.1%): Arthritis[Ref]


Uncommon (0.1% to 1%): Vision disturbance, eye irritation[Ref]


Common (1% to 10%): Fatigue, edema, non-cardiac chest pain, weakness, viral infection
Uncommon (0.1% to 1%): Vertigo, tinnitus, ear ache, fever, influenza-like syndrome, weight gain, sensation of cold, fall, pain, sudden death, lower extremity edema, swelling of extremity, peripheral edema, thoracic pain
Rare (less than 0.1%): Weakness in one extremity
Frequency not reported: Serositis[Ref]


Frequency not reported: Anaphylactoid reactions, positive antinuclear antibodies (ANA)[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Monopril (fosinopril)." Bristol-Myers Squibb, Princeton, NJ.

Some side effects of Monopril may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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