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Moduretic 5-50 Side Effects

Generic name: amiloride / hydrochlorothiazide

Medically reviewed by Drugs.com. Last updated on Apr 27, 2023.

Note: This document contains side effect information about amiloride / hydrochlorothiazide. Some dosage forms listed on this page may not apply to the brand name Moduretic 5-50.

Applies to amiloride / hydrochlorothiazide: oral tablet.

Warning

Oral route (Tablet)

May cause hyperkalemia, which is potentially fatal if uncorrected. The risk is higher in patients with renal impairment or diabetes mellitus. Monitor serum potassium levels carefully in any patient receiving therapy..

Serious side effects of Moduretic 5-50

Along with its needed effects, amiloride/hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amiloride / hydrochlorothiazide:

More common

Less common

Rare

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking amiloride / hydrochlorothiazide:

Symptoms of overdose

Other side effects of Moduretic 5-50

Some side effects of amiloride / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Rare

For Healthcare Professionals

Applies to amiloride / hydrochlorothiazide: oral tablet.

General

The most common adverse reactions were headache, weakness, nausea/anorexia, dizziness, and rash.[Ref]

Gastrointestinal

Common (1% to 10%): Nausea/anorexia, diarrhea, gastrointestinal pain, abdominal pain

Frequency not reported: Constipation, gastrointestinal bleeding, gastrointestinal disturbance, abdominal fullness, vomiting, flatulence

Amiloride:

Frequency not reported: Activation of probable preexisting peptic ulcer, dyspepsia, heartburn, dry mouth

Hydrochlorothiazide:

Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation[Ref]

Dermatologic

Common (1% to 10%): Rash, pruritus

Frequency not reported: Diaphoresis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia

Amiloride:

Frequency not reported: Alopecia, itching, diaphoresis

Hydrochlorothiazide:

Frequency not reported: Cutaneous vasculitis, photosensitivity, urticaria, purpura, toxic epidermal necrolysis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Syncope, paresthesia/numbness, vertigo, stupor, sleepiness, bad taste

Amiloride:

Frequency not reported: Encephalopathy, tremors, tinnitus, somnolence[Ref]

Other

Common (1% to 10%): Weakness, fatigue/tiredness

Frequency not reported: Malaise, chest pain, digitalis toxicity, gynecomastia

Amiloride:

Frequency not reported: Fatigability

Hydrochlorothiazide:

Frequency not reported: Fever[Ref]

Metabolic

Common (1% to 10%): Serum potassium greater than 5.5 mEq/L

Frequency not reported: Appetite changes, anorexia, thirst, gout, dehydration, symptomatic hyponatremia, electrolyte imbalance, hyponatremia

Hydrochlorothiazide:

Frequency not reported: Electrolyte imbalance, hyperglycemia, hyperuricemia, hypokalemia[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia

Frequency not reported: Tachycardia, orthostatic hypotension, angina pectoris, flushing

Amiloride:

Frequency not reported: Palpitation, partial heart block increased to complete heart block

Hydrochlorothiazide:

Frequency not reported: Vasculitis[Ref]

Musculoskeletal

Common (1% to 10%): Leg ache

Frequency not reported: Back pain, muscle cramps/spasm, joint pain

Amiloride:

Frequency not reported: Painful extremities, neck/shoulder ache[Ref]

Respiratory

Common (1% to 10%): Dyspnea

Frequency not reported: Hiccups, nasal congestion

Amiloride:

Frequency not reported: Shortness of breath, cough

Hydrochlorothiazide:

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]

Genitourinary

Frequency not reported: Impotence, nocturia, dysuria, incontinence

Amiloride:

Frequency not reported: Bladder spasm, polyuria, urinary frequency

Hydrochlorothiazide:

Frequency not reported: Glycosuria[Ref]

Psychiatric

Frequency not reported: Insomnia, nervousness, depression, mental confusion

Amiloride:

Frequency not reported: Libido decreased

Hydrochlorothiazide:

Frequency not reported: Restlessness[Ref]

Renal

Frequency not reported: Renal dysfunction, renal failure

Hydrochlorothiazide:

Frequency not reported: Interstitial nephritis[Ref]

Ocular

Frequency not reported: Visual disturbance

Amiloride:

Frequency not reported: Intraocular pressure increased

Hydrochlorothiazide:

Frequency not reported: Transient blurred vision, xanthopsia[Ref]

Immunologic

Frequency not reported: Anaphylactic reaction

Hydrochlorothiazide:

Frequency not reported: Anaphylactic reaction[Ref]

Hematologic

Amiloride:

Frequency not reported: Aplastic anemia, neutropenia

Hydrochlorothiazide:

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia[Ref]

Hepatic

Amiloride:

Frequency not reported: Abnormal liver function, jaundice

Hydrochlorothiazide:

Frequency not reported: Intrahepatic cholestatic jaundice[Ref]

References

1. Product Information. Moduretic (amiloride-hydrochlorothiazide). Merck & Co., Inc. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.