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Moduretic 5-50 Side Effects

Generic name: amiloride / hydrochlorothiazide

Medically reviewed by Last updated on May 6, 2022.

Note: This document contains side effect information about amiloride / hydrochlorothiazide. Some of the dosage forms listed on this page may not apply to the brand name Moduretic 5-50.

For the Consumer

Applies to amiloride/hydrochlorothiazide: oral tablet


Oral route (Tablet)

May cause hyperkalemia, which is potentially fatal if uncorrected. The risk is higher in patients with renal impairment or diabetes mellitus. Monitor serum potassium levels carefully in any patient receiving therapy..

Side effects requiring immediate medical attention

Along with its needed effects, amiloride / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amiloride / hydrochlorothiazide:

More common

Less common


  • Ankle, knee, or great toe joint pain
  • arm, back, or jaw pain
  • blistering, peeling, or loosening of the skin
  • bloody or black, tarry stools
  • bloody urine
  • burning while urinating
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain, discomfort, or heaviness
  • chills
  • cloudy urine
  • cold sweats
  • coma
  • constipation
  • cough
  • cracks in the skin
  • decreased awareness or responsiveness
  • decreased frequency or amount of urine
  • diarrhea
  • difficult or painful urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • dry mouth
  • fever
  • headache
  • increase in heart rate
  • increased blood pressure
  • increased thirst
  • itching
  • joint pain, stiffness, or swelling
  • lightheadedness
  • loss of appetite
  • loss of heat from the body
  • lower back or side pain
  • muscle pain or cramps
  • pounding heartbeat or pulse
  • rapid breathing
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • seizures
  • severe sleepiness
  • severe stomach pain
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sunken eyes
  • sweating
  • swelling of the face, ankles, hands, fingers, or lower legs
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain
  • wrinkled skin

Incidence not known

  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow or scar-like area

Get emergency help immediately if any of the following symptoms of overdose occur while taking amiloride / hydrochlorothiazide:

Symptoms of overdose

  • Drowsiness
  • irritability
  • mood changes
  • pain or weakness in the hands or feet
  • trembling
  • weak pulse

Side effects not requiring immediate medical attention

Some side effects of amiloride / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Leg ache


  • Bad taste
  • bloated, full feeling
  • blurred or loss of vision
  • changes in appetite
  • decreased interest in sexual intercourse
  • discouragement
  • disturbed color perception
  • double vision
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • feeling sad or empty
  • general feeling of discomfort or illness
  • hair loss or thinning of hair
  • hiccups
  • inability to have or keep an erection
  • increased sweating
  • increased urge to urinate during the night
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • loss of bladder control
  • loss of interest or pleasure
  • muscle spasm
  • night blindness
  • overbright appearance of lights
  • passing of gas
  • redness of the face, neck, arms, and occasionally upper chest
  • seeing halos around lights
  • sensation of spinning
  • sleepiness
  • sleeplessness
  • stomach fullness or discomfort
  • stuffy nose
  • swelling of the breasts or breast soreness in both females and males
  • trouble concentrating
  • trouble sleeping
  • tunnel vision
  • unable to sleep
  • waking to urinate at night

For Healthcare Professionals

Applies to amiloride / hydrochlorothiazide: oral tablet


The most common adverse reactions were headache, weakness, nausea/anorexia, dizziness, and rash.[Ref]


Common (1% to 10%): Nausea/anorexia, diarrhea, gastrointestinal pain, abdominal pain

Frequency not reported: Constipation, gastrointestinal bleeding, gastrointestinal disturbance, abdominal fullness, vomiting, flatulence


Frequency not reported: Activation of probable preexisting peptic ulcer, dyspepsia, heartburn, dry mouth


Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation[Ref]


Common (1% to 10%): Rash, pruritus

Frequency not reported: Diaphoresis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia


Frequency not reported: Alopecia, itching, diaphoresis


Frequency not reported: Cutaneous vasculitis, photosensitivity, urticaria, purpura, toxic epidermal necrolysis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Syncope, paresthesia/numbness, vertigo, stupor, sleepiness, bad taste


Frequency not reported: Encephalopathy, tremors, tinnitus, somnolence[Ref]


Common (1% to 10%): Weakness, fatigue/tiredness

Frequency not reported: Malaise, chest pain, digitalis toxicity, gynecomastia


Frequency not reported: Fatigability


Frequency not reported: Fever[Ref]


Common (1% to 10%): Serum potassium greater than 5.5 mEq/L

Frequency not reported: Appetite changes, anorexia, thirst, gout, dehydration, symptomatic hyponatremia, electrolyte imbalance, hyponatremia


Frequency not reported: Electrolyte imbalance, hyperglycemia, hyperuricemia, hypokalemia[Ref]


Common (1% to 10%): Arrhythmia

Frequency not reported: Tachycardia, orthostatic hypotension, angina pectoris, flushing


Frequency not reported: Palpitation, partial heart block increased to complete heart block


Frequency not reported: Vasculitis[Ref]


Common (1% to 10%): Leg ache

Frequency not reported: Back pain, muscle cramps/spasm, joint pain


Frequency not reported: Painful extremities, neck/shoulder ache[Ref]


Common (1% to 10%): Dyspnea

Frequency not reported: Hiccups, nasal congestion


Frequency not reported: Shortness of breath, cough


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Frequency not reported: Impotence, nocturia, dysuria, incontinence


Frequency not reported: Bladder spasm, polyuria, urinary frequency


Frequency not reported: Glycosuria[Ref]


Frequency not reported: Insomnia, nervousness, depression, mental confusion


Frequency not reported: Libido decreased


Frequency not reported: Restlessness[Ref]


Frequency not reported: Renal dysfunction, renal failure


Frequency not reported: Interstitial nephritis[Ref]


Frequency not reported: Visual disturbance


Frequency not reported: Intraocular pressure increased


Frequency not reported: Transient blurred vision, xanthopsia[Ref]


Frequency not reported: Anaphylactic reaction


Frequency not reported: Anaphylactic reaction[Ref]



Frequency not reported: Aplastic anemia, neutropenia


Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia[Ref]



Frequency not reported: Abnormal liver function, jaundice


Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


1. "Product Information. Moduretic (amiloride-hydrochlorothiazide)." Merck & Company Inc (2001):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.