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Meprobamate Side Effects

For the Consumer

Applies to meprobamate: oral capsule extended release, oral tablet

In addition to its needed effects, some unwanted effects may be caused by meprobamate. In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking meprobamate, check with your doctor or nurse as soon as possible:

Less common:
  • Skin rash, hives, or itching
Rare
  • Confusion
  • fast, pounding, or irregular heartbeat
  • sore throat and fever
  • unusual bleeding or bruising
  • unusual excitement
  • wheezing, shortness of breath, or troubled breathing
Symptoms of overdose:
  • Confusion (severe)
  • dizziness or lightheadedness (continuing)
  • drowsiness (severe)
  • shortness of breath or slow or troubled breathing
  • slow heartbeat
  • slurred speech
  • staggering
  • weakness (severe)

Minor Side Effects

Some of the side effects that can occur with meprobamate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Clumsiness or unsteadiness
  • drowsiness
Less common:
  • Blurred vision or change in near or distant vision
  • diarrhea
  • dizziness or lightheadedness
  • false sense of well-being
  • headache
  • nausea or vomiting
  • unusual tiredness or weakness

Side Effects: Post Treatment

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

  • Clumsiness or unsteadiness
  • confusion
  • convulsions (seizures)
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • increased dreaming
  • muscle twitching
  • nausea or vomiting
  • nervousness or restlessness
  • nightmares
  • trembling
  • trouble in sleeping

For Healthcare Professionals

Applies to meprobamate: oral tablet

General

CNS effects such as drowsiness and dizziness may occur, but these usually resolve as treatment continues; allergic or idiosyncratic reactions have occurred and are generally seen within the first to fourth dose.[Ref]

Nervous system

Frequency not reported: Drowsiness, ataxia, dizziness, slurred speech, headache, weakness, paresthesia, overstimulation, fast EEG activity[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity reactions
Frequency not reported: Itchy, urticarial, or erythematous maculopapular rash, anaphylaxis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, bullous dermatitis, fixed drug eruption with cross reaction to carisoprodol, cross sensitivity between meprobamate/mebutamate and meprobamate/carbromal[Ref]

Hypersensitivity reactions have been reported in about 2% of patients. Milder hypersensitivity reactions are characterized by an itchy, urticarial, or erythematous maculopapular rash which may be generalized or localized to the groin. More serious hypersensitivity reactions have included rare reports of anaphylaxis, hypotension and collapse; erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, and bullous dermatitis (1 fatal case).[Ref]

Dermatologic

Frequency not reported: Erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, bullous dermatitis, angioneurotic edema[Ref]

Respiratory

Frequency not reported: Bronchospasm[Ref]

Cardiovascular

Frequency not reported: Palpitation, tachycardia, arrhythmias, transient ECG changes, syncope, hypotensive crisis, peripheral edema[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, diarrhea, stomatitis, proctitis[Ref]

Hematologic

Rare (0.01% to 0.1%): thrombocytopenic purpura
Frequency not reported: Leukopenia, acute nonthrombocytopenic purpura, petechiae, ecchymosis, eosinophilia, adenopathy, agranulocytosis, aplastic anemia, pancytopenia[Ref]

Metabolic

Frequency not reported: Exacerbation of porphyria[Ref]

Ocular

Frequency not reported: Impaired visual accommodation

Other

Rare (0.01% to 0.1%): hyperpyrexia
Frequency not reported: Vertigo, fever, chills[Ref]

Psychiatric

Frequency not reported: Euphoria, paradoxical excitement, withdrawal symptoms[Ref]

Genitourinary

Frequency not reported: Oliguria, anuria[Ref]

References

1. "Product Information. Meprobamate (meprobamate)." Alembic Pharmaceuticals, Bridgewater, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for meprobamate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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