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Meprobamate Dosage

Medically reviewed on August 23, 2018.

Applies to the following strengths: 400 mg; 200 mg; 600 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anxiety

1200 to 1600 mg orally divided in 3 or 4 doses
Maximum dose: 2400 mg per day

Comments:
-The lowest effective dose should be used in order to limit oversedation.
-The effectiveness beyond 4 months has not been assessed.

Uses: Management of anxiety disorders or for the short-term relief of anxiety symptoms.

Usual Pediatric Dose for Anxiety

Age: 6 to 12 years:
200 to 600 mg orally divided in 2 or 3 doses

Age: 13 years or older:
1200 to 1600 mg orally divided in 3 or 4 doses
Maximum dose: 2400 mg per day

Comments:
-The lowest effective dose should be used in order to limit oversedation.
-The effectiveness beyond 4 months has not been assessed.

Uses: Management of anxiety disorders or for the short-term relief of anxiety symptoms

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Elderly: Use with cation; dose selection should be cautious starting at the low end of the dosing range.

Abrupt discontinuation should be avoided; reduce dose gradually over a period of 1 to 2 weeks; alternatively, a long-acting barbiturate may be substituted, then gradually withdrawn.

Precautions

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally 3 to 4 times a day

General:
-Careful supervision of dose and amounts prescribed is necessary since this drug is known to produce physical and psychological dependence.
-Abrupt discontinuation, especially after prolonged use, should be avoided; onset of withdrawal symptoms is usually within 12 to 48 hours and symptoms usually cease within the next 12 to 48 hours.
-Continued need should be regularly reassessed.

Monitoring:
-Monitor for over sedation
-Monitor for abuse

Patient advice:
-Patients should be advised that this drug may impair their ability to perform hazardous tasks including driving.
-Patients should be aware that this drug has been known to be abused producing physical and psychological dependence when used at higher than recommended doses; withdrawal reactions are possible and patients should discuss discontinuation with their healthcare provider.
-Patients should be informed that their tolerance for alcohol and other CNS depressants will be diminished; concurrent use is generally not recommended, but should be discussed with their healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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