Meprobamate Dosage

Medically reviewed by Drugs.com. Last updated on Jun 13, 2024.

Usual Adult Dose for Anxiety

1200 to 1600 mg orally divided in 3 or 4 doses
Maximum dose: 2400 mg per day

Comments:

• The lowest effective dose should be used in order to limit oversedation.
• The effectiveness beyond 4 months has not been assessed.

Uses: Management of anxiety disorders or for the short-term relief of anxiety symptoms.

Usual Pediatric Dose for Anxiety

Age: 6 to 12 years:
200 to 600 mg orally divided in 2 or 3 doses

Age: 13 years or older:
1200 to 1600 mg orally divided in 3 or 4 doses
Maximum dose: 2400 mg per day

Comments:

• The lowest effective dose should be used in order to limit oversedation.
• The effectiveness beyond 4 months has not been assessed.

Uses: Management of anxiety disorders or for the short-term relief of anxiety symptoms

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Elderly: Use with cation; dose selection should be cautious starting at the low end of the dosing range.

Abrupt discontinuation should be avoided; reduce dose gradually over a period of 1 to 2 weeks; alternatively, a long-acting barbiturate may be substituted, then gradually withdrawn.

Precautions

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:

• Take orally 3 to 4 times a day

General:

• Careful supervision of dose and amounts prescribed is necessary since this drug is known to produce physical and psychological dependence.
• Abrupt discontinuation, especially after prolonged use, should be avoided; onset of withdrawal symptoms is usually within 12 to 48 hours and symptoms usually cease within the next 12 to 48 hours.
• Continued need should be regularly reassessed.

Monitoring:

• Monitor for over sedation
• Monitor for abuse

Patient advice:

• Patients should be advised that this drug may impair their ability to perform hazardous tasks including driving.
• Patients should be aware that this drug has been known to be abused producing physical and psychological dependence when used at higher than recommended doses; withdrawal reactions are possible and patients should discuss discontinuation with their healthcare provider.
• Patients should be informed that their tolerance for alcohol and other CNS depressants will be diminished; concurrent use is generally not recommended, but should be discussed with their healthcare provider.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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