Lozol Side Effects

Generic name: indapamide

Medically reviewed by Drugs.com. Last updated on Jun 4, 2024.

Note: This document provides detailed information about Lozol.

Applies to indapamide: oral tablet Side Effects associated with indapamide. Some dosage forms listed on this page may not apply specifically to the brand name Lozol.

Applies to indapamide: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Check with your doctor right away if you have confusion, decreased urine, dizziness, drowsiness, dry mouth, increased thirst, fast or irregular heartbeat or pulse, headache, muscle pains or cramps, nausea or vomiting, seizures, swelling of the face, ankles, or hands, trouble breathing, or unusual tiredness or weakness. These may be symptoms of an electrolyte imbalance (eg, low sodium or potassium in the blood).

This medicine may cause changes in your blood sugar levels. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Check with your doctor right away if you have blurred vision, difficulty in reading, eye pain, or any other change in vision during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.

Serious side effects of Lozol

Along with its needed effects, indapamide (the active ingredient contained in Lozol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking indapamide:

Other side effects of Lozol

Some side effects of indapamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to indapamide: compounding powder, oral tablet.

General adverse events

Most adverse side effects are mild and transient.^[Ref]

Dermatologic

Dermatologic reactions, such as rashes, occur in less than 5% of patients, and comprise up to 36% of all adverse drug reactions associated with indapamide (the active ingredient contained in Lozol) ^[Ref]

Metabolic

Metabolic abnormalities are common, but are rarely clinically significant. Hypokalemia occurs in 15% of patients, although clinically relevant hypokalemia is reported in only 1% and 3% of patients receiving 2.5 and 5.0 mg/day, respectively. Hyponatremia, hyperglycemia, and hyperuricemia are reported in 1% to 5% of patients but are rarely clinically relevant. Unlike the thiazides, indapamide (the active ingredient contained in Lozol) has little or no adverse effect on the lipid profile. Severe cases of hyponatremia, accompanied by hypokalemia have been reported with recommended doses of indapamide in elderly females.^[Ref]

Renal

Renal side effects are unusual, consisting primarily of azotemia.^[Ref]

A case of interstitial nephritis and an urticarial rash associated with indapamide has been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects include dyspepsia, constipation, diarrhea, flatulence, and dry mouth in less than 5% of patients.^[Ref]

Nervous system

Nervous system side effects include dizziness, lightheadedness, headache, and fatigue in 5% of patients.^[Ref]

Cardiovascular

Cardiovascular side effects are usually limited to postural hypotension. Indapamide (the active ingredient contained in Lozol) does not affect the heart rate.^[Ref]

Musculoskeletal

Musculoskeletal cramps are reported in about 5% of patients. A single case of skeletal muscle damage has been associated with indapamide (the active ingredient contained in Lozol) ^[Ref]

A 71-year-old woman with a history of psychiatric problems and reflux esophagitis developed chest pain, finger numbness, sweating, and nausea while gardening. Her medications included indapamide, trifluoperazine, oxazepam, and ranitidine. Myocardial infarction was definitively ruled out by ECG and CPK isoenzyme analysis. Interesting laboratory values included a reduced serum sodium (117 mmol/L), elevated LDH and AST enzymes, and elevated CPK-MM isoenzymes. There was no history of muscular trauma, and thyroid function tests were normal. The hyponatremia and elevated CPK-MM fractions fell precipitously upon hydration with normal saline. A definite causal link between indapamide and rhabdomyolysis could not be made, but thiazide diuretics have been previously implicated in some cases of hypokalemia with subsequent muscle damage.^[Ref]

Genitourinary

Genitourinary side effects generally reflect the activity of the drug, with less than 5% of patients reporting polyuria and nocturia.^[Ref]

Decreased sexual libido is rare, with up to 88% of patients reporting no change and most of the remaining 12% reporting improvement of sexual libido during indapamide therapy.^[Ref]

Hepatic

A case of reversible hepatitis associated with indapamide (the active ingredient contained in Lozol) has been reported.^[Ref]

Hepatic side effects are rare, at least one case of hepatitis has been reported.^[Ref]

Hypersensitivity

Hypersensitivity reactions occur in less than 5% of patients. Cases of severe reactions including toxic epidermal necrolysis, erythema multiforme, and Stevens-Johnson syndrome have been reported. Patients with a sulfa allergy may react to indapamide (the active ingredient contained in Lozol) ^[Ref]

Endocrine

Endocrine side effects include at least one case of indapamide-induced hyperparathyroidism. In one study, indapamide (the active ingredient contained in Lozol) significantly reduced parathyroid hormone levels in all patients.^[Ref]

Hematologic

Hematologic side effects are rare, but have included at least one case of mild thrombocytopenia and mucosal bleeding from the tongue. Bleeding stopped promptly and platelet counts returned to normal following discontinuation of indapamide (the active ingredient contained in Lozol) ^[Ref]

See also:

Further information

Lozol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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