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Lotensin HCT Side Effects

Generic name: benazepril / hydrochlorothiazide

Medically reviewed by Last updated on Apr 28, 2023.

Note: This document contains side effect information about benazepril / hydrochlorothiazide. Some dosage forms listed on this page may not apply to the brand name Lotensin HCT.

Applies to benazepril / hydrochlorothiazide: oral tablet.


Oral route (Tablet)

Discontinue benazepril hydrochloride/hydrochlorothiazide as soon as possible upon awareness of a pregnancy. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Serious side effects of Lotensin HCT

Along with its needed effects, benazepril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benazepril / hydrochlorothiazide:

Less common

  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, slow, or irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • unusual tiredness or weakness
  • weakness and heaviness of the legs
  • wrinkled skin


  • Black, tarry stools
  • bloating
  • burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
  • chest pain
  • chills
  • constipation
  • cough or hoarseness
  • darkened urine
  • diarrhea
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • fever
  • headache
  • indigestion
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • pains in the stomach or side, possibly radiating to the back
  • persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • sensation of spinning
  • shiny bump
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • trouble breathing
  • unusual bleeding or bruising
  • vomiting
  • white, yellow or waxy scar-like area
  • yellow eyes or skin

Other side effects of Lotensin HCT

Some side effects of benazepril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Cough
  • decreased interest in sexual intercourse
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • muscle stiffness
  • muscle tension or tightness
  • sensation of spinning
  • sleepiness or unusual drowsiness


  • Blistering, peeling, loosening of the skin
  • diarrhea
  • hives or welts, itching, skin rash
  • increased sensitivity of skin to sunlight
  • joint or muscle pain
  • pinpoint red or purple spots on the skin
  • redness of the skin
  • redness or other discoloration of the skin
  • red irritated eyes
  • red skin lesions, often with a purple center
  • severe sunburn

For Healthcare Professionals

Applies to benazepril / hydrochlorothiazide: oral tablet.


The most common side effects were dizziness, fatigue, headache, and cough.[Ref]

Nervous system

Common (1% to 10%): Dizziness, postural dizziness, headache, hypertonia, somnolence

Uncommon (0.1% to 1%): Paresthesia, taste perversion, tinnitus, syncope, hypesthesia


Postmarketing reports: Lightheadedness, headache, paresthesia[Ref]


Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis

Uncommon (0.1% to 1%): Epistaxis, bronchitis, voice alteration


Postmarketing reports: Eosinophilic pneumonitis


Postmarketing reports: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Common (1% to 10%): Fatigue, vertigo, flu syndrome

Uncommon (0.1% to 1%): Asthenia, chest pain, fever, chills


Postmarketing reports: Vertigo, weakness, pyrexia, asthenia[Ref]


Common (1% to 10%): Impotence, urinary frequency

Uncommon (0.1% to 1%): Urinary tract infection[Ref]


Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, constipation, dry mouth, abdominal pain, gastroenteritis, flatulence, tooth disorder


Postmarketing reports: Pancreatitis, small bowel angioedema, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation[Ref]


Common (1% to 10%): Back pain

Uncommon (0.1% to 1%): Arthralgia, myalgia, neck pain, arthritis


Postmarketing reports: Muscle spasm[Ref]


Uncommon (0.1% to 1%): Rash, sweating, photosensitivity, pruritus, alopecia


Postmarketing reports: Stevens-Johnson syndrome, pemphigus


Postmarketing reports: Purpura, urticaria, rash, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis[Ref]


Uncommon (0.1% to 1%): Insomnia, nervousness, libido decreased, abnormal dreams


Postmarketing reports: Restlessness[Ref]


Uncommon (0.1% to 1%): Palpitations, flushing, peripheral vascular disorder, tachycardia


Postmarketing reports: Necrotizing angiitis[Ref]


Uncommon (0.1% to 1%): Abnormal vision, retinal disorder, conjunctivitis


Postmarketing reports: Transient blurred vision, xanthopsia[Ref]


Uncommon (0.1% to 1%): Anorexia


Postmarketing reports: Anorexia, hyperglycemia, glycosuria, hyperuricemia[Ref]


Uncommon (0.1% to 1%): Infection


Postmarketing reports: Anaphylactoid reactions[Ref]


Frequency not reported: Serum creatinine increased, BUN increased[Ref]



Postmarketing reports: Hemolytic anemia, thrombocytopenia


Postmarketing reports: Aplastic anemia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia[Ref]



Postmarketing reports: Pancreatitis


Postmarketing reports: Intrahepatic cholestatic jaundice[Ref]



Postmarketing reports: Parathyroid gland changes with hypercalcemia and hypophosphatemia[Ref]


1. Product Information. Lotensin HCT (benazepril-hydrochlorothiazide). Ciba-Geigy Pharmaceuticals. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.