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Lotensin

Generic Name: benazepril (ben AY ze pril)
Brand Names: Lotensin

Medically reviewed by P. Thornton, DipPharm. Last updated on May 9, 2019.

What is Lotensin?

Lotensin (benazepril) is an ACE inhibitor. ACE stands for angiotensin converting enzyme.

Lotensin is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack

Lotensin may also be used for purposes not listed in this medication guide.

Important Information

Do not use Lotensin if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you have ever had angioedema. Do not take Lotensin within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use benazepril together with any medication that contains aliskiren (a blood pressure medicine).

Before taking this medicine

You should not use Lotensin if you are allergic to benazepril, or if:

Do not take Lotensin within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use benazepril together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking Lotensin with aliskiren if you have kidney disease.

To make sure this medicine is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);

  • liver disease;

  • heart disease; or

  • an organ transplant.

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Lotensin can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breast-feed while you are using benazepril.

Lotensin is not approved for use by anyone younger than 6 years old.

How should I take Lotensin?

Take Lotensin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may take Lotensin with or without food.

Drink plenty of water each day while you are taking this medicine.

Your blood pressure will need to be checked often. Your kidney function may also need to be checked.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking Lotensin.

If you need surgery, tell the surgeon ahead of time that you are using Lotensin.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

Lotensin dosing information

Usual Adult Dose for Hypertension:

Initial dose: With a diuretic: 5 mg orally once a day; without a diuretic: 10 mg orally once a day
Maintenance dose: 20 to 40 mg/day orally as a single dose or in two equally divided doses
Maximum dose: 80 mg/day

Comments:
-The divided dose regimen was more effective in controlling pre-dosing blood pressure.
-If discontinuing a diuretic prior to initiating this drug to reduce the likelihood of hypotension, conclude diuretic therapy 2 to 3 days prior to starting this drug.

Usual Pediatric Dose for Hypertension:

6 YEARS OR OLDER:
Initial dose: 0.2 mg/kg orally once a day as monotherapy
Maximum dose: 0.6 mg/kg; 40 mg/day

Comments:
-Doses between 0.1 and 0.6 mg/kg once a day have been studied; doses greater than 0.1 mg/kg were shown to reduce blood pressure; doses above 0.6 mg/kg or 40 mg/day have not been studied in pediatric patients.
-Prepare a suspension for pediatric patients who cannot swallow tablets or for whom the calculated dosage does not correspond to available tablet strengths.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lotensin?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Lotensin can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of benazepril.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Lotensin side effects

Get emergency medical help if you have signs of an allergic reaction to Lotensin (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • little or no urinating;

  • high potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or

  • liver problems - stomach pain (upper right side), loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).

Common Lotensin side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lotensin?

Tell your doctor about all your current medicines. Many drugs can interact with benazepril, especially:

This list is not complete and many other drugs may interact with benazepril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lotensin only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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