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Ipratropium Inhalation Solution Side Effects

Generic Name: ipratropium

Note: This document contains side effect information about ipratropium. Some of the dosage forms listed on this page may not apply to the brand name Ipratropium Inhalation Solution.

For the Consumer

Applies to ipratropium: inhalation aerosol liquid, inhalation aerosol powder, inhalation solution

Along with its needed effects, ipratropium (the active ingredient contained in Ipratropium Inhalation Solution) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ipratropium:

More common
  • Bladder pain
  • bloody or cloudy urine
  • cough producing mucus
  • difficult, burning, or painful urination
  • difficulty with breathing
  • frequent urge to urinate
  • lower back or side pain
  • shortness of breath
  • tightness in the chest
  • wheezing
Less common
  • Body aches or pain
  • chills
  • cough
  • ear congestion
  • fever
  • headache
  • loss of voice
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Rare
  • Constipation (continuing) or lower abdominal pain or bloating
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • severe eye pain
  • skin rash or hives
  • swelling of the face, lips, or eyelids
Incidence not known
  • Blindness
  • blurred vision
  • confusion
  • decrease in the frequency of urination
  • decrease in the urine volume
  • decreased vision
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea or vomiting
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • redness of the white part of the eyes or inside of the eyelids
  • sweating
  • tearing

Some side effects of ipratropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • dryness of the mouth
  • unpleasant taste
Less common or rare
  • Acid or sour stomach
  • belching
  • burning eyes
  • diarrhea
  • general feeling of discomfort or illness
  • heartburn
  • indigestion
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nervousness
  • pain or tenderness around the eyes and cheekbones
  • shivering
  • stomach discomfort, upset, or pain
  • trembling
  • trouble sleeping

For Healthcare Professionals

Applies to ipratropium: compounding powder, inhalation aerosol, inhalation solution

General

The most common adverse reactions were bronchitis, COPD exacerbation, dyspnea, headache, throat irritation, cough, dry mouth, gastro-intestinal motility disorders (including constipation, diarrhea and vomiting), nausea, and dizziness.[Ref]

Respiratory

Very common (10% or more): Bronchitis (up to 14.6%), upper respiratory tract infection (up to 13.2%)
Common (1% to 10%): Chest pain, cough, dyspnea, bronchospasm, sputum increased, pharyngitis, rhinitis, sinusitis, throat irritation
Uncommon (0.1% to 1%): Paradoxical bronchospasm, laryngospasm, pharyngeal edema, dry throat[Ref]

Gastrointestinal

Common (1% to 10%): Mouth dryness, nausea, gastrointestinal motility disorder, dyspepsia
Uncommon (0.1% to 1%): Constipation, diarrhea, taste perversion, vomiting, stomatitis
Frequency not reported: Mouth edema[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Urinary retention[Ref]

Musculoskeletal

Common (1% to 10%): Back pain
Uncommon (0.1% to 1%): Arthritis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Tremor, nervousness[Ref]

Other

Common (1% to 10%): Influenza-like symptoms, pain[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Hypertension, palpitations, supraventricular tachycardia
Rare (less than 0.1%): Atrial fibrillation, rate increased
Frequency not reported: Hypotension, palpitation, tachycardia[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus
Rare (less than 0.1%): Urticaria[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity, anaphylactic reactions, angioedema of tongue, lips, face
Frequency not reported: Urticaria (including giant urticaria), laryngospasm[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision, mydriasis, intraocular pressure increased, glaucoma, eye pain, halo vision, conjunctival hyperemia, corneal edema
Rare (less than 0.1%): Accommodation disorder
Frequency not reported: Precipitation or worsening of narrow-angle glaucoma, acute eye pain[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Ipratropium." Med Lett Drugs Ther 29 (1987): 71-2

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Pakes GE, Brogden RN, Heel RC, Speight TM, Avery GS "Ipratropium bromide: a review of its pharmacological properties and therapeutic efficacy in asthma and chronic bronchitis." Drugs 20 (1980): 237-66

5. "Product Information. Atrovert (ipratropium)." Boehringer-Ingelheim, Ridgefield, CT.

6. "Product Information. Atrovent (ipratropium)." Boehringer-Ingelheim, Ridgefield, CT.

7. Anderson WM "Hemodynamic and non-bronchial effects of ipratropium bromide." Am J Med 81 (1986): 45-53

8. Massey KL, Gotz VP "Ipratropium bromide." Drug Intell Clin Pharm 19 (1985): 5-12

9. Gross NJ "Ipratropium bromide." N Engl J Med 319 (1988): 486-94

10. Levin DC, Little KS, Laughlin KR, Galbraith JM, Gustman PM, Murphy D, Kram JA, Hardie G, Reuter C, Ostransky D, Mcfarland K "Addition of anticholinergic solution prolongs bronchodilator effect of beta(2) agonists in patients with chronic obstructive pulmonary disease." Am J Med 100 Suppl (1996): s40-8

11. Verheijen-Breemhaar L, Bogaard JM, Hilvering C "Comparison of the bronchodilatory action and side-effects of ipratropium bromide and thiazinamium methyl sulphate: a long-term, double-blind, crossover trial in patients with chronic bronchitis." Pharmatherapeutica 3 (1982): 180-7

12. Pras E, Stienlauf S, Pinkhas J, Sidi Y "Urinary retention associated with ipratropium bromide." DICP 25 (1991): 939-40

13. Lozewicz S "Bladder outflow obstruction induced by ipratropium bromide." Postgrad Med J 65 (1989): 260-1

14. Braun SR, Levy SF "Comparison of ipratropium bromide and albuterol in chronic obstructive pulmonary disease: a three-center study." Am J Med 91 (1991): s28-32

15. O'Driscoll BR "Supraventricular tachycardia caused by nebulised ipratropium bromide." Thorax 44 (1989): 312

16. Cabana MD, Johnson H, Lee CKK, Helfaer M "Transient anisocoria secondary to nebulized ipratropium bromide." Clin Pediat 37 (1998): 445-7

17. Kizer KM, Bess DT, Bedford NK "Blurred vision from ipratropium bromide." Am J Health Syst Pharm 56 (1999): 914

Some side effects of Ipratropium Inhalation Solution may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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