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Intal Side Effects

Generic Name: cromolyn

Note: This page contains information about the side effects of cromolyn. Some of the dosage forms included on this document may not apply to the brand name Intal.

For the Consumer

Applies to cromolyn: oral capsule, oral solution

In addition to its needed effects, some unwanted effects may be caused by cromolyn (the active ingredient contained in Intal). In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking cromolyn:

Rare:
  • Coughing
  • difficulty in swallowing
  • hives or itching of skin
  • swelling of face, lips, or eyelids
  • wheezing or difficulty in breathing

Severity: Moderate

If any of the following side effects occur while taking cromolyn, check with your doctor or nurse as soon as possible:

Less common:
  • Skin rash

Severity: Minor

Some of the side effects that can occur with cromolyn may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea
  • headache
Less common:

Note: If the above side effects occur in patients with mastocytosis, they are usually only temporary and could be symptoms of the disease.

  • Abdominal pain
  • irritability
  • muscle pain
  • nausea
  • trouble in sleeping

For Healthcare Professionals

Applies to cromolyn: compounding powder, inhalation aerosol with adapter, inhalation solution, nasal spray, oral capsule, oral solution

General

Adverse reactions following use of this drug are rare; headache and diarrhea have been reported following oral use, while cough, nasal congestion, sneezing and wheezing have been reported with oral inhalation.[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis, laryngeal edema[Ref]

Respiratory

Frequency not reported: Pharyngitis, dyspnea, cough, nasal congestion, sneezing, wheezing, nasal itching, nose bleed, nose burning
Postmarketing reports: Bronchospasm, pulmonary infiltrates with eosinophilia, hoarseness[Ref]

Hematologic

Frequency not reported: Polycythemia, neutropenia, pancytopenia
Postmarketing reports: Anemia[Ref]

Genitourinary

Postmarketing reports: Dysuria, urinary frequency[Ref]

Dermatologic

Rare (less than 0.1%): Pruritus, rash
Frequency not reported: Urticaria/angioedema, erythema/burning, photosensitivity, purpura
Postmarketing reports: Photodermatitis, exfoliative dermatitis[Ref]

Gastrointestinal

Rare (0.01% to 0.1%): Abdominal pain, nausea,
Frequency not reported: Diarrhea, constipation, dyspepsia, flatulence, glossitis, stomatitis, vomiting, dysphagia, oesophagospasm, unpleasant taste, stomachache, mild throat irritation
Postmarketing reports: Swollen parotid gland[Ref]

Hepatic

Frequency not reported: Abnormal hepatic function test[Ref]

Cardiovascular

Frequency not reported: Flushing, tachycardia, premature ventricular contractions, palpitations, chest pain
Postmarketing reports: Periarteritic vasculitis, pericarditis[Ref]

Musculoskeletal

Rare (less than 0.1%): Myalgia
Frequency not reported: Arthralgia, stiffness/weakness of legs, lupus erythematosus syndrome
Postmarketing reports: Joint swelling and pain, polymyositis[Ref]

Nervous system

Rare (0.01% to 0.1%): Headache
Frequency not reported: Dizziness, hypoesthesia, paresthesia, migraine, convulsions
Postmarketing reports: Peripheral neuritis[Ref]

Psychiatric

Frequency not reported: Psychosis, anxiety, depression, hallucinations, behavior change, insomnia, nervousness[Ref]

Other

Frequency not reported: Fatigue, malaise, tinnitus
Postmarketing reports: Vertigo[Ref]

Ocular

Postmarketing reports: Lacrimation[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Cromolyn Sodium (cromolyn (sodium cromoglycate))." Teva Pharmaceuticals (formerly IVAX), Miami, FL.

4. "Product Information. Gastrocrom (cromolyn (sodium cromoglycate))." Celltech Pharmaceuticals Inc, Rochester, NY.

Not all side effects for Intal may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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