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Hydrochlorothiazide / Metoprolol Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 10, 2024.

Applies to hydrochlorothiazide / metoprolol: oral tablet.

Serious side effects

Along with its needed effects, hydrochlorothiazide/metoprolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / metoprolol:

More common

  • chest pain or discomfort
  • decreased urine
  • dry mouth
  • increased thirst
  • lightheadedness, dizziness, or fainting
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • seizures
  • slow or irregular heartbeat
  • unusual tiredness or weakness

Less common

  • ankle, knee, or great toe joint pain
  • chest tightness
  • decreased ability to exercise
  • difficult or labored breathing
  • joint stiffness or swelling
  • lower back or side pain
  • swelling of the face, fingers, feet, or lower legs

Incidence not known

  • persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow or waxy scar-like area

Get emergency help immediately if any of the following symptoms of overdose occur while taking hydrochlorothiazide / metoprolol:

Symptoms of overdose

Other side effects

Some side effects of hydrochlorothiazide / metoprolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • chills
  • diarrhea
  • feeling of constant movement of self or surroundings
  • fever
  • general feeling of discomfort or illness
  • muscle aches
  • nightmares
  • runny nose
  • sensation of spinning
  • shivering
  • sleepiness
  • sore throat
  • trouble sleeping
  • unusual drowsiness, dullness, or feeling of sluggishness

Less common

  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • earache
  • hearing loss
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • pinpoint red or purple spots on the skin
  • weight loss

For healthcare professionals

Applies to hydrochlorothiazide / metoprolol: oral tablet, oral tablet extended release.

General

The most common side effects were fatigue, lethargy, flu syndrome, dizziness, vertigo, drowsiness, somnolence, and headache.[Ref]

Gastrointestinal

Hydrochlorothiazide:

Metoprolol:

Nervous system

Hydrochlorothiazide:

Metoprolol:

Other

Hydrochlorothiazide:

Metoprolol:

Metabolic

Hydrochlorothiazide:

Metoprolol:

Dermatologic

Hydrochlorothiazide:

Metoprolol:

Gangrene has been reported very rarely in patients with preexisting severe peripheral circulatory disorders who were taking metoprolol.[Ref]

Respiratory

Hydrochlorothiazide:

Metoprolol:

Cardiovascular

Hydrochlorothiazide:

Metoprolol:

Ocular

Hydrochlorothiazide:

Metoprolol:

Psychiatric

Hydrochlorothiazide:

Metoprolol:

Genitourinary

Hydrochlorothiazide:

Metoprolol:

Musculoskeletal

Hydrochlorothiazide:

Metoprolol:

Immunologic

Hydrochlorothiazide:

Hepatic

Hydrochlorothiazide:

Metoprolol:

Hematologic

Hydrochlorothiazide:

Renal

Hydrochlorothiazide:

References

1. (2022) "Product Information. Lopressor HCT (hydrochlorothiazide-metoprolol)." Novartis Pharmaceuticals

Further information

Hydrochlorothiazide/metoprolol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.