Skip to main content

Hydrochlorothiazide / metoprolol Pregnancy and Breastfeeding Warnings

Medically reviewed by Last updated on Aug 25, 2022.

Hydrochlorothiazide / metoprolol is also known as: Dutoprol, Lopressor HCT

Hydrochlorothiazide / metoprolol Pregnancy Warnings

Animal studies have revealed evidence of decreased postnatal survival and increased postimplantation and fetal loss. There are no controlled data in human pregnancy.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.

US FDA pregnancy category: C

See references

Hydrochlorothiazide / metoprolol Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Yes (hydrochlorothiazide, metoprolol [in small amounts])

A mother taking metoprolol would transfer less than 1 mg/L to a breastfeeding infant.

See references

References for pregnancy information

  1. "Product Information. Lopressor HCT (hydrochlorothiazide-metoprolol)." Novartis Pharmaceuticals (2022):

References for breastfeeding information

  1. "Product Information. Lopressor HCT (hydrochlorothiazide-metoprolol)." Novartis Pharmaceuticals (2022):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.