Hydrochlorothiazide / metoprolol Pregnancy and Breastfeeding Warnings

Brand names: Dutoprol, Lopressor HCT

Medically reviewed by Drugs.com. Last updated on Jun 12, 2024.

Hydrochlorothiazide / metoprolol Pregnancy Warnings

This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.

US FDA pregnancy category: Not assigned.

Risk summary: Adverse fetal outcomes, including fetal or neonatal jaundice, thrombocytopenia, hypoglycemia, and electrolyte abnormalities have been reported following maternal use of thiazide diuretics.

Comments:
-If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.
-This drug enters fetal circulation and can cause placental hypoperfusion.
-Neonates exposed to metoprolol during pregnancy may have a higher risk of developing bradycardia, hypoglycemia, hypotension, and respiratory depression.

Animal studies have revealed evidence of decreased postnatal survival and increased postimplantation and fetal loss. There are no controlled data in human pregnancy.

US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

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Hydrochlorothiazide / metoprolol Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Yes (hydrochlorothiazide, metoprolol [in small amounts])

A mother taking metoprolol would transfer less than 1 mg/L to a breastfeeding infant.

See references

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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