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Hydrochlorothiazide / Methyldopa Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 30, 2024.

Applies to hydrochlorothiazide / methyldopa: oral tablet.

Other side effects

Some side effects of hydrochlorothiazide / methyldopa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • dizziness or light-headedness when getting up from a lying or sitting position
  • drowsiness
  • dryness of mouth
  • headache

Less common

  • decreased sexual ability or interest in sex
  • diarrhea
  • increased sensitivity of skin to sunlight (skin rash, itching, redness or other discoloration of skin or severe sunburn after exposure to sunlight)
  • loss of appetite
  • numbness, tingling, pain, or weakness in hands or feet
  • slow heartbeat
  • stuffy nose
  • swelling of breasts or unusual milk production

Serious side effects

Along with its needed effects, hydrochlorothiazide/methyldopa may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / methyldopa:

Rare

  • unexplained fever shortly after starting to take this medicine
  • cough or hoarseness
  • dark or amber urine
  • diarrhea or stomach cramps (severe or continuing)
  • fever, chills, troubled breathing, and fast heartbeat
  • general feeling of discomfort or illness or weakness
  • joint pain
  • lower back or side pain
  • painful or difficult urination
  • pale stools
  • skin rash, hives, or itching
  • stomach pain (severe) with nausea and vomiting
  • tiredness or weakness after having taken this medicine for several weeks (continuing)
  • yellow eyes or skin

Check with your doctor as soon as possible if any of the following side effects occur while taking hydrochlorothiazide / methyldopa:

Signs and symptoms of too much potassium loss

Less common

  • mental depression or anxiety
  • nightmares or unusually vivid dreams

For healthcare professionals

Applies to hydrochlorothiazide / methyldopa: oral tablet.

Cardiovascular

Hydrochlorothiazide:

Methyldopa:

Dermatologic

Hydrochlorothiazide:

Methyldopa:

Gastrointestinal

Hydrochlorothiazide:

Methyldopa:

Hematologic

Hydrochlorothiazide:

Methyldopa:

Nervous system

Hydrochlorothiazide:

Methyldopa:

Hepatic

Hydrochlorothiazide:

Methyldopa:

Other

Hydrochlorothiazide:

Methyldopa:

Psychiatric

Hydrochlorothiazide:

Methyldopa:

Genitourinary

Hydrochlorothiazide:

Methyldopa:

Immunologic

Hydrochlorothiazide:

Methyldopa:

Metabolic

Hydrochlorothiazide:

Methyldopa:

Musculoskeletal

Hydrochlorothiazide:

Methyldopa:

Renal

Hydrochlorothiazide:

Methyldopa:

Respiratory

Hydrochlorothiazide:

Methyldopa:

Endocrine

Methyldopa:

Ocular

Hydrochlorothiazide:

References

1. "Product Information. Aldoril 25 (hydrochlorothiazide-methyldopa)." Merck & Co., Inc

Further information

Hydrochlorothiazide/methyldopa side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.