Hydrochlorothiazide / Methyldopa Dosage
Medically reviewed by Drugs.com. Last updated on Aug 4, 2021.
Applies to the following strengths: 15 mg-250 mg; 25 mg-250 mg; 30 mg-500 mg; 50 mg-500 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial doses (as determined by titration of the individual components):
-Hydrochlorothiazide 15 mg-Methyldopa 250 mg orally 2 or 3 times a day, OR
-Hydrochlorothiazide 25 mg-Methyldopa 250 mg orally twice a day, OR
-Hydrochlorothiazide 30 to 50 mg-Methyldopa 500 mg orally once a day
Maximum dose: Hydrochlorothiazide 50 mg/day
-This drug is not indicated for initial therapy. Dosage must be individualized, as determined by titration of the individual components.
-Initiate dose increases in the evening to minimize sedation.
-Tolerance to methyldopa may occur, usually between the second and third month of therapy. Additional separate doses of methyldopa or replacement of this drug with the individual components may be required.
-If this drug is given with antihypertensives other than thiazides, the initial dose of methyldopa should be limited to 500 mg a day in divided doses.
Renal Dose Adjustments
Mild to moderate renal dysfunction: Data not available
Severe renal dysfunction: Use with caution
If progressive renal impairment becomes evident: Consider withholding or discontinuing this drug
Liver Dose Adjustments
Contraindicated in patients with active hepatic disease
US BOXED WARNING:
-INITIAL THERAPY: This fixed combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not static, but must be re-evaluated as conditions in each patient warrant.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
Storage requirements: Protect from light.
-Metabolic: Serum electrolytes prior to starting treatment and periodically thereafter.
More about hydrochlorothiazide / methyldopa
- Side Effects
- During Pregnancy
- Drug Images
- Drug Interactions
- En Español
- Drug class: antiadrenergic agents (central) with thiazides
- Patient Information
- Methyldopa and hydrochlorothiazide (Advanced Reading)
- Methyldopa and Hydrochlorothiazide
- Other brands
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