Antiadrenergic agents (central) with thiazides

Centrally acting antiadrenergic with thiazides is a combination medicine that contains both a centrally acting antiadrenergic agent with a thiazide diuretic. This combination is used to treat hypertension.

Centrally acting antiadrenergic agents block the andrenergic receptors in the central nervous system by reducing catecholamines release and effect. This causes the heart to beat slower with more force and the blood vessels to dilate which reduces blood pressure.

Thiazide diuretics decrease active re-absorption of sodium and chloride ions by inhibiting the sodium/chloride co-transporter in the distal convoluted tubule. They also increase potassium ion loss. Thiazide diuretics decrease the blood volume by diuresis and are used to decrease blood pressure.