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Guselkumab Side Effects

For the Consumer

Applies to guselkumab: subcutaneous solution

Along with its needed effects, guselkumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking guselkumab:

More common
Less Common
  • Burning or stinging of the skin
  • diarrhea
  • itching in the genital or other skin areas
  • loss of appetite
  • nausea
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • scaling
  • stomach pain
  • White patches in the mouth or throat or on the tongue

Some side effects of guselkumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty in moving
  • muscle pain or stiffness
  • pain in the joints
  • Headache, severe and throbbing
  • hives or welts
  • itching, skin rash
  • redness of the skin

For Healthcare Professionals

Applies to guselkumab: subcutaneous solution


Very common (10% or more): Infections (23%)
Common (1% to 10%): Tinea infections, herpes simplex infections, immunogenicity[Ref]


Common (1% to 10%): Injection site reactions (e.g., injection site erythema, bruising, hematoma, hemorrhage, swelling, edema, pruritus, pain, discoloration, induration, inflammation, urticaria)[Ref]


Common (1% to 10%): Arthralgia[Ref]


Common (1% to 10%): Elevated liver enzymes[Ref]


Very common (10% or more): Respiratory tract infection (e.g., nasopharyngitis, upper respiratory tract infection, pharyngitis, viral upper respiratory tract infection) (14%)[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Common (1% to 10%): Diarrhea, gastroenteritis (including viral gastroenteritis)[Ref]


1. "Product Information. Tremfya (guselkumab)." Janssen Biotech, Inc., Horsham, PA, PA.

Some side effects of guselkumab may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.