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Formoterol / glycopyrrolate Side Effects

Medically reviewed by Last updated on Jul 4, 2022.

For the Consumer

Applies to formoterol/glycopyrrolate: inhalation aerosol powder

Side effects requiring immediate medical attention

Along with its needed effects, formoterol / glycopyrrolate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking formoterol / glycopyrrolate:

Less common

  • Bladder pain
  • bloody or cloudy urine
  • chest pain
  • chills
  • cough
  • diarrhea
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • shivering
  • sore throat
  • stuffy or runny nose
  • sweating
  • tightness of the chest
  • trouble sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Agitation
  • blurred vision
  • decrease in the frequency of urination
  • difficulty in passing urine (dribbling)
  • dizziness
  • dry mouth
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • flushed, dry skin
  • fruit-like breath odor
  • hives or welts, itching, or skin rash
  • hoarseness
  • increased hunger
  • increased thirst
  • irritation
  • joint stiffness or swelling
  • redness of the skin
  • restlessness
  • stomach pain
  • swelling of the eyelids, face, lips, hands, or feet
  • tremor
  • trouble swallowing
  • unexplained weight loss

Side effects not requiring immediate medical attention

Some side effects of formoterol / glycopyrrolate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to formoterol / glycopyrrolate: inhalation aerosol


Common (1% to 10%): Cough (4%); In less than 2%: Chest pain, influenza, acute sinusitis[Ref]


Frequency not reported: Formoterol fumarate: Palpitations, cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia, extrasystoles)[Ref]


Common (1% to 10%): In less than 2%: Tooth abscess, oropharyngeal pain, vomiting, dry mouth

Frequency not reported: Formoterol fumarate: Nausea[Ref]


Common (1% to 10%): Urinary tract infection (2.6%)

Frequency not reported: Worsening of urinary retention[Ref]


Frequency not reported: Hypersensitivity reactions (formoterol fumarate)[Ref]


Frequency not reported: Formoterol fumarate: Hyperglycemia[Ref]


Common (1% to 10%): In less than 2%: Arthralgia, muscle spasm, pain in the extremity[Ref]

Nervous system

Common (1% to 10%): In less than 2%: Headache, dizziness

Frequency not reported: Formoterol fumarate: Tremor[Ref]


Frequency not reported: Worsening of narrow-angle glaucoma[Ref]


Common (1% to 10%): In less than 2%: Fall, fatigue, contusion[Ref]


Common (1% to 10%): Anxiety (less than 2%)

Frequency not reported: Paradoxical bronchospasm; Formoterol fumarate: Restlessness, sleep disturbances, agitation[Ref]


1. "Product Information. Bevespi Aerosphere (formoterol-glycopyrrolate)." Astra-Zeneca Pharmaceuticals (2016):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.