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Bevespi Aerosphere

Generic name: formoterol and glycopyrrolatefor-MOE-ter-ol-and-GLYE-koe-PIR-oh-late ]
Drug class: Bronchodilator combinations

Medically reviewed by Philip Thornton, DipPharm. Last updated on Dec 28, 2022.

What is Bevespi Aerosphere?

Bevespi Aerosphere is an inhalation aerosol containing a combination of formoterol and glycopyrrolate. Formoterol is a bronchodilator. Glycopyrrolate is an anticholinergic. These medications work by relaxing muscles in the airways to improve breathing.

Bevespi Aerosphere is used to prevent airflow obstruction or bronchospasm and reduce flare-ups in adults with COPD (chronic obstructive pulmonary disease), including bronchitis and emphysema.

Bevespi Aerosphere is not for use in treating asthma.

Formoterol may increase the risk of death in people with asthma, but the risk in people with COPD is not known. Talk with your doctor about your individual risk.


Bevespi Aerosphere is for use only in people with chronic obstructive pulmonary disease (COPD) and should not be used to treat asthma.

Bevespi Aerosphere is not a rescue medicine. It will not work fast enough to treat a bronchospasm attack.

Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Before taking this medicine

You should not use Bevespi Aerosphere if you are allergic to formoterol or glycopyrrolate. This medicine is for use only in people with COPD and should not be used to treat asthma.

To make sure Bevespi Aerosphere is safe for you, tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

This medicine is not approved for use by anyone younger than 18 years old.

How should I use Bevespi Aerosphere?

Use Bevespi Aerosphere exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Use the medicine exactly as directed. Using too much of this medicine can cause life-threatening side effects.

Read and follow all patient instructions provided with the inhaler device. Ask your doctor or pharmacist if you do not understand these instructions.

Use only the inhaler device provided with your medicine or you may not get the correct dose. Use the new inhaler each time you get your prescription refilled.

Shake the Bevespi Aerosphere well just before you inhale your dose.

This medicine is not a rescue medicine for bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

You should not stop using Bevespi Aerosphere suddenly. Stopping suddenly may make your condition worse.

Store at room temperature away from moisture, heat, and light. Keep the inhaler device in the sealed foil tray until ready to start using it.

Keep Bevespi away from an open flame or high heat. The canister may explode if it gets too hot. Do not puncture or burn an empty inhaler canister.

Throw the inhaler device away 3 months after you have taken it out of the foil pouch, or if the dose indicator shows a zero, whichever comes first.

Dosing information

Usual Adult Dose for Chronic Obstructive Pulmonary Disease -- Maintenance:

2 inhalations orally twice a day, in the morning and in the evening
Maximum dose: 2 inhalations twice daily

-Two inhalations of formoterol 4.8 mcg-glycopyrrolate 9 mcg equal one dose.

Uses: Long-term, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause vomiting, severe constipation, blurred vision, chest pain, heart problems, or fainting.

What should I avoid while using Bevespi Aerosphere?

If this medicine gets in your eyes, rinse them with water and call your doctor if you have ongoing eye redness even after rinsing.

Do not use a second inhaled bronchodilator that contains formoterol or a similar medicine (such as arformoterol, indacaterol, olodaterol, salmeterol, or vilanterol).

Bevespi side effects

Get emergency medical help if you have signs of an allergic reaction to Bevespi: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • tremors, nervousness, chest pain, fast or pounding heartbeats;

  • wheezing, choking, or other breathing problems after using this medicine;

  • painful or difficult urination;

  • blurred vision, tunnel vision, eye pain or redness, or seeing halos around lights;

  • high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or

  • low potassium level - leg cramps, constipation, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle weakness or limp feeling.

Common Bevespi side effects may include:

  • cough; or

  • urination problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Bevespi?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with formoterol and glycopyrrolate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Bevespi Aerosphere can be used with a spacer device if recommended by your doctor. The method of using a metered-dose inhaler can be challenging for some patients making inhalation difficult. A spacer device can help to deliver the medicine more easily to your lungs. If you are having trouble inhaling your medicine, contact your doctor to discuss the use of a spacer device. Continue reading

Bevespi Aerosphere aerosol inhaler contains either 120 or 28 inhalations (puffs) depending up the size of the inhaler you receive. Your canister will last 30 days (with the 120 count inhaler) or 7 days (with the 28 count inhaler). Continue reading

You may notice some improvement in your breathing within minutes to hours after using Bevespi Aerosphere (formoterol fumarate and glycopyrrolate), but it is considered a long-term, inhaled maintenance treatment for chronic obstructive pulmonary disease (COPD). Bevespi Aerosphere is not used to treat sudden breathing problems. Use a fast-acting rescue inhaler such as albuterol for sudden breathing problems. Continue reading

Bevespi Aerosphere is a metered dose inhaler (MDI) handheld canister that gives you your medicine as an inhaled mist. Bevespi Aerosphere delivers 9 micrograms (mcg) of glycopyrrolate and 4.8 mcg of formoterol fumarate per inhalation for the long-term treatment of chronic obstructive pulmonary disease (COPD). It is not used as a fast-acting (rescue) inhaler. Continue reading

Bevespi Aerosphere is normally given as 2 inhalations twice a day for COPD, in the morning and in the evening, via a pressurized metered dose inhaler. Follow the illustrated instructions enclosed with your inhaler, and if you have questions, ask your pharmacist or doctor. Your healthcare provider can show you how to use the inhaler.  Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Bevespi Aerosphere only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.