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Bevespi Aerosphere Side Effects

Generic Name: formoterol / glycopyrrolate

Note: This document contains side effect information about formoterol / glycopyrrolate. Some of the dosage forms listed on this page may not apply to the brand name Bevespi Aerosphere.

For the Consumer

Applies to formoterol / glycopyrrolate: inhalation aerosol powder

Along with its needed effects, formoterol/glycopyrrolate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking formoterol / glycopyrrolate:

Less common
  • Bladder pain
  • bloody or cloudy urine
  • chest pain
  • cough
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
Incidence not known
  • Blindness
  • blurred vision
  • decrease in the frequency of urination
  • decrease in urine volume
  • decreased vision
  • difficulty with breathing
  • dizziness
  • eye pain
  • fainting
  • headache
  • hives or welts, itching, or skin rash
  • irregular heartbeat
  • nausea or vomiting
  • nervousness
  • noisy breathing
  • pounding in the ears
  • recurrent large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness of the skin
  • slow or fast heartbeat
  • tearing
  • tightness in the chest

Some side effects of formoterol / glycopyrrolate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Difficulty with moving
  • dry mouth
  • fear
  • fever
  • muscle pain or stiffness
  • muscle spasm
  • pain in the arms or legs
  • pain in the joints
  • pain or tenderness around the eyes and cheekbones
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to formoterol / glycopyrrolate: inhalation aerosol


Common (1% to 10%): Cough (4%); In less than 2%: Chest pain, influenza, acute sinusitis[Ref]


Frequency not reported: Formoterol fumarate: Palpitations, cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia, extrasystoles)[Ref]


Common (1% to 10%): In less than 2%: Tooth abscess, oropharyngeal pain, vomiting, dry mouth
Frequency not reported: Formoterol fumarate: Nausea[Ref]


Common (1% to 10%): Urinary tract infection (2.6%)
Frequency not reported: Worsening of urinary retention[Ref]


Frequency not reported: Hypersensitivity reactions (formoterol fumarate)[Ref]


Frequency not reported: Formoterol fumarate: Hyperglycemia[Ref]


Common (1% to 10%): In less than 2%: Arthralgia, muscle spasm, pain in the extremity[Ref]

Nervous system

Common (1% to 10%): In less than 2%: Headache, dizziness
Frequency not reported: Formoterol fumarate: Tremor[Ref]


Frequency not reported: Worsening of narrow-angle glaucoma[Ref]


Common (1% to 10%): In less than 2%: Fall, fatigue, contusion[Ref]


Common (1% to 10%): Anxiety (less than 2%)
Frequency not reported: Paradoxical bronchospasm; Formoterol fumarate: Restlessness, sleep disturbances, agitation[Ref]


1. "Product Information. Bevespi Aerosphere (formoterol-glycopyrrolate)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Some side effects of Bevespi Aerosphere may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.