Erleada Side Effects
Generic Name: apalutamide
Medically reviewed by Drugs.com. Last updated on Oct 20, 2020.
Note: This document contains side effect information about apalutamide. Some of the dosage forms listed on this page may not apply to the brand name Erleada.
For the Consumer
Applies to apalutamide: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, apalutamide (the active ingredient contained in Erleada) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking apalutamide:
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred vision
- depressed mood
- difficulty with moving
- dry skin and hair
- feeling cold
- hair loss
- hoarseness or husky voice
- joint pain
- muscle cramp, pain, and stiffness
- pain in the arms or legs
- pounding in the ears
- rapid weight gain
- slow or fast heartbeat
- tingling of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
- weight gain
- Bloody urine
- chest pain or discomfort
- decreased urine output
- dilated neck veins
- extreme tiredness or weakness
- irregular breathing or heartbeat
- pain in the shoulders, arms, jaw, or neck
- tightness in the chest
- troubled breathing
Side effects not requiring immediate medical attention
Some side effects of apalutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Decreased appetite
- decreased weight
- feeling of warmth
- itching, skin rash
- redness of the face, neck, arms, and occasionally, upper chest
For Healthcare Professionals
Applies to apalutamide: oral tablet
Very common (10% or more): Anemia (70%), leukopenia (47%), lymphopenia (41%)[Ref]
Very common (10% or more): Hypercholesterolemia (76%), hyperglycemia (70%), hypertriglyceridemia (67%), hyperkalemia (32%), appetite disorder (appetite decreased, early satiety, hypophagia) (12%)[Ref]
Very common (10% or more): Fatigue/asthenia (39%), fall (16%), edema (peripheral edema, generalized edema, edema, edema genital, penile edema, peripheral swelling, scrotal edema, lymphedema, swelling, localized edema) (11%)[Ref]
Very common (10% or more): Hypertension (25%), hot flush (14%)
Common (1% to 10%): Ischemic heart disease, heart failure
Frequency not reported: Myocardial infarction, cardiopulmonary arrest[Ref]
Very common (10% or more): Rash (maculopapular rash, generalized rash, urticaria, rash pruritic, rash macular, conjunctivitis, erythema multiforme, rash papular, skin exfoliation, genital rash, rash erythematous, stomatitis, drug eruption, mouth ulceration, rash pustular, blister, papule, pemphigoid, skin erosion, and rash vesicular) (24%)
Very common (10% or more): Thyroid stimulating hormone elevated
Common (1% to 10%): Hypothyroidism[Ref]
Very common (10% or more): Diarrhea (20%), nausea (18%)[Ref]
Uncommon (0.1% to 1%): Seizure
Very common (10% or more): Arthralgia (16%), fracture (e.g., rib fracture, lumbar vertebral fracture, spinal compression fracture, spinal fracture, foot fracture, hip fracture, humerus fracture, thoracic vertebral fracture, upper limb fracture, fractured sacrum, hand fracture, pubis fracture, acetabulum fracture, ankle fracture, compression fracture, costal cartilage fracture, facial bones fracture, lower limb fracture, osteoporotic fracture, wrist fracture, avulsion fracture, fibula fracture, fractured coccyx, pelvic fracture, radius fracture, sternal fracture, stress fracture, traumatic fracture, cervical vertebral fracture, femoral neck fracture, tibia fracture) (12%)[Ref]
Frequency not reported: Infection[Ref]
1. "Product Information. Erleada (apalutamide)." Janssen Biotech, Inc., Horsham, PA, PA.
Frequently asked questions
- How long do you have to take Erleada (apalutamide) for?
- How effective is Erleada (apalutamide)?
- What type of prostate cancer is Erleada used to treat?
More about Erleada (apalutamide)
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 2 Reviews
- Drug class: antiandrogens
- FDA Approval History
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.