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How long do you have to take Erleada (apalutamide) for?

Medically reviewed by Melisa Puckey, BPharm. Last updated on April 27, 2021.

Official Answer

by Drugs.com

Erleada (apalutamide) is usually taken until cancer progresses past a certain point or you start to have unacceptable side effects.

  • In the SPARTAN clinical trial (NCT01946204) using apalutamide for men with castration-resistant metastasis-free prostate cancer, some patients were still using apalutamide at 36 months.
  • In the TITAN clinical trial (NCT02489318) studying men using apalutamide for metastatic, castration-sensitive prostate cancer, some patients were still taking it after 2 years.

Erleada is an androgen blocker.

  • Androgens, such as testosterone, can help prostate cancer growth.
  • As Erleada blocks androgens effect on the tumor, it makes it harder for the tumor to advance.
  • This means patients taking Erleada have a longer overall survival and have a longer time before their disease progresses.
References
  • Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer:  https://www.nejm.org/doi/full/10.1056/NEJMoa1715546
  • Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer: https://www.nejm.org/doi/full/10.1056/nejmoa1903307
  • Erleada Professional Medication Information: https://www.drugs.com/pro/erleada.html

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