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What type of drug is Talzenna?

Medically reviewed by Last updated on Sep 8, 2020.

Official Answer


Talzenna (talazoparib) is a poly (ADP-ribose) polymerase (PARP) inhibitor.

Talzenna (talazoparib) used for the treatment of patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2-negative locally advanced or metastatic breast cancer. Patients are selected for this treatment based on an FDA-approved diagnostic test.

PARP inhibitors are used to treat cancers that have mistakes in their DNA repair genes, such as with the BRCA gene mutation. PARP is a protein that is involved with cancer cell growth, regulation and repair. PARP inhibitors stop the cancer cells from being repaired which leads to cell death and a reduction in tumor growth. PARP inhibitors are used to treat cancers such as:

  • ovarian cancer
  • fallopian tube cancer
  • peritoneal cancer
  • breast cancer
  • prostate cancer

Other PARP inhibitors include:

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