Is Zytiga a form of chemotherapy?
Official answer
by Drugs.comZytiga (abiraterone acetate) is a type of hormone therapy that is used along with prednisone to treat men with prostate cancer that has spread to other parts of the body (metastasized). Despite being used to treat cancer, Zytiga is not a form of chemotherapy.
Zytiga is approved by the US Food and Drug Administration (FDA) to treat:
- Metastatic castration-resistant prostate cancer (CRPC)
- Metastatic high-risk castration-sensitive prostate cancer (CSPC)
How does Zytiga work?
Zytiga is an androgen biosynthesis inhibitor. Androgens are a group of hormones, which includes testosterone, that stimulate prostate cancer cells to grow.
Zytiga works by inhibiting the CYP17 (17 α-hydroxylase/C17,20-lyase) enzyme found in testicular, adrenal and prostate tumor tissue. The CYP17 enzyme is necessary for the production of androgens - a process called androgen biosynthesis. Blocking CYP17 significantly reduces the production of the androgens which stimulate prostate cancer cells to grow.
References
- Food and Drug Administration. Zytiga. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202379s031s033lbl.pdf. [Accessed May 27, 2021].
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Drug information
- Zytiga Information for Consumers
- Zytiga Information for Healthcare Professionals (includes dosage details)
- Side Effects of Zytiga (detailed)
Related support groups
- Zytiga (8 questions, 35 members)
- Prostate Cancer (49 questions, 145 members)