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How effective is Casodex for prostate cancer?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Nov 22, 2023.

Official answer


Casodex (biclutamide) is an anti-androgen type of hormone therapy used to treat prostate cancer that has metastasized (spread to other parts of the body.)
When Casodex is used in combination with a luteinizing hormone-releasing hormone (LHRH) analog (either leuprolide depot or goserelin implant) Casodex + LHRH analog are

  • more effective than leuprolide on its own
  • is just as effective as flutamide + leuprolide.

A clinical study for Stage D2 Prostate Carcinoma comparing leuprolide with leuprolide + flutamide showed:

  • leuprolide + flutamide treatment increased survival time by 7 months which was a 25% improvement

Another clinical trial was completed comparing treatment of Casodex + LHRH analog with flutamide + LHRH analog for Stage D2 Prostate Carcinoma. The results showed both treatment options had similar effects with no significant difference between:

  • survival time (time to death)
  • time to tumor progression
  • quality of life

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