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How effective is Casodex (bicalutamide) for prostate cancer?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Dec 2, 2020.

Official Answer

by Drugs.com

How effective is Casodex for prostate cancer?

Casodex (biclutamide) is an anti-androgen type of hormone therapy used to treat prostate cancer that has metastasized (spread to other parts of the body.)
When Casodex is used in combination with a luteinizing hormone-releasing hormone (LHRH) analog (either leuprolide depot or goserelin implant) Casodex + LHRH analog are

  • more effective than leuprolide on its own
  • is just as effective as flutamide + leuprolide.

A clinical study for Stage D2 Prostate Carcinoma comparing leuprolide with leuprolide + flutamide showed:

  • leuprolide + flutamide treatment increased survival time by 7 months which was a 25% improvement

Another clinical trial was completed comparing treatment of Casodex + LHRH analog with flutamide + LHRH analog for Stage D2 Prostate Carcinoma. The results showed both treatment options had similar effects with no significant difference between:

  • survival time (time to death)
  • time to tumor progression
  • quality of life
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