Zytiga Side Effects
Generic name: abiraterone
Medically reviewed by Drugs.com. Last updated on Jul 30, 2022.
Note: This document contains side effect information about abiraterone. Some of the dosage forms listed on this page may not apply to the brand name Zytiga.
Common side effects of Zytiga include: decreased serum potassium, increased serum aspartate aminotransferase, increased serum triglycerides, fluid retention, and hypokalemia. Other side effects include: hypertension. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to abiraterone: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, abiraterone (the active ingredient contained in Zytiga) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking abiraterone:
- Bladder pain
- bloody or cloudy urine
- blurred vision
- body aches or pain
- decreased urine
- difficult, burning, or painful urination
- dry mouth
- ear congestion
- fast, slow, or irregular heartbeat
- frequent urge to urinate
- increased thirst
- loss of appetite
- loss of voice
- lower back or side pain
- mood changes
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- pounding in the ears
- runny or stuffy nose
- slow or fast heartbeat
- sore throat
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- Chest pain, discomfort, or tightness
- dilated neck veins
- irregular breathing
- weight gain
Incidence not known
- Clay-colored stools
- dark urine
- general feeling of discomfort or illness
- itching, rash
- muscle cramp, spasm, pain, or stiffness
- stomach pain, continuing
- thickening of bronchial secretions
- unpleasant breath odor
- vomiting of blood
- yellow eyes or skin
Side effects not requiring immediate medical attention
Some side effects of abiraterone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- feeling of warmth
- groin pain
- increased urge to urinate during the night
- joint swelling or discomfort
- redness of the face, neck, arms, and occasionally, upper chest
- trouble sleeping
- waking to urinate at night
For Healthcare Professionals
Applies to abiraterone: oral tablet
Uncommon (0.1% to 1%): Adrenocortical insufficiency[Ref]
Very common (10% or more): Elevated ALT (up to 41.9%), elevated AST (up to 37.3%)
Common (1% to 10%): Elevated total bilirubin
Postmarketing reports: Fulminant hepatitis, acute liver failure and death[Ref]
Very common (10% or more): Hot flush (up to 22.3%), hypertension (up to 21.6%)
Common (1% to 10%): Arrhythmia, chest pain/chest discomfort, angina pectoris, atrial fibrillation, tachycardia, myocardial infarction/ischemia, cardiac failure (e.g., congestive heart failure, left ventricular dysfunction, decreased ejection fraction)
Frequency not reported: QT prolongation[Ref]
Very common (10% or more): Joint swelling/discomfort (up to 30.3%), muscle discomfort (up to 26.2%), contusion (up to 13.3%)
Common (1% to 10%): Groin pain, fractures, falls
Postmarketing reports: Rhabdomyolysis, myopathy[Ref]
Very common (10% or more): Lymphopenia (up to 38.2%), anemia[Ref]
Very common (10% or more): Hypertriglyceridemia (up to 62.5%), hyperglycemia (up to 56.6%), hypernatremia (up to 32.8%), hypokalemia (up to 28.3%), fluid retention/edema (up to 26.7%), hypophosphatemia (up to 23.8%), elevated alkaline phosphatase, hypercholesterolemia[Ref]
Frequency not reported: Renal failure[Ref]
Very common (10% or more): Fatigue (up to 39.1%)
Postmarketing reports: Non-infectious pneumonitis, allergic alveolitis[Ref]
Very common (10% or more): Urinary tract infection (up to 12%), hematuria (up to 10.3%)
Common (1% to 10%): Rash[Ref]
Frequently asked questions
- Xtandi vs Zytiga: How do they compare?
- How long do you take Zytiga for?
- Is Zytiga a form of chemotherapy?
- What's the difference between Yonsa and Zytiga?
- Why is prednisone prescribed with Zytiga?
- What does abiraterone therapy do?
More about Zytiga (abiraterone)
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (37)
- Drug images
- Pricing & coupons
- Generic availability
- En español
- Drug class: miscellaneous antineoplastics
- FDA approval history
Related treatment guides
1. "Product Information. Zytiga (abiraterone)." Centocor Inc (2011):
2. "Product Information. Yonsa (abiraterone)." Sun Pharmaceutical Industries (2018):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.