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Enoxacin Side Effects

Applies to enoxacin: oral tablet

General

Enoxacin therapy is generally well tolerated, and adverse effects are mild in nature. Discontinuation of therapy due to adverse effects occurs in approximately 3% of patients.[Ref]

Gastrointestinal

Gastrointestinal disturbances due to enoxacin therapy may occur in up to 9% of patients. This most frequently includes nausea, abdominal pain, anorexia, dyspepsia, and diarrhea. Enoxacin therapy has resulted in pseudomembranous colitis although it has minimal effect on the anaerobic flora of the GI tract.[Ref]

Nervous system

Nervous system adverse effects occur in approximately 2% to 3% of patients. These most commonly include headache, dizziness, fatigue, nervousness, agitation, and insomnia. Seizures have also been reported in susceptible patients.[Ref]

Hypersensitivity

Hypersensitivity reactions resulting in rash and pruritus have been reported in up to 1% of patients treated with enoxacin. Photosensitivity can occur. Erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson Syndrome have also been reported.[Ref]

Hepatic

Asymptomatic elevations in hepatic transaminases have been reported in less than 1% of patients treated with enoxacin. Cholestatic jaundice has been reported in one patient shortly after enoxacin administration.[Ref]

Hematologic

Hematologic abnormalities such as eosinophilia and leukopenia occur in less than 1% of enoxacin-treated patients.[Ref]

Musculoskeletal

Arthralgias and myalgias occur rarely.[Ref]

Cardiovascular

Tachycardia and facial flushing have been reported rarely.[Ref]

Other

Women treated with enoxacin may experience vaginal pruritus and vaginitis.[Ref]

References

1. Foot M, Williams G, Want S, et al "An open study of the safety and efficacy of enoxacin in complicated urinary tract infections." J Antimicrob Chemother 21 (1988): 97-103

2. Scarpazza G, Della Torre F, Scaglione F, Fraschini F "Efficacy and safety of enoxacin in the treatment of respiratory infections." Int J Clin Pharmacol Res 9 (1989): 43-7

3. Bailey RR, Gorrie SI, Peddie BA, Davies PR "Double blind, randomised trial comparing single dose enoxacin and trimethoprim for treatment of bacterial cystitis." N Z Med J 100 (1987): 618-9

4. Jaber LA, Bailey EM, Rybak MJ "Enoxacin: a new fluoroquinolone." Clin Pharm 8 (1989): 97-107

5. Bailey RR, Walker RJ, Lynn KL, et al "Intravenous enoxacin for the treatment of pylenephritis: pharmacokinetic and clinical study." Br J Clin Pharmacol 25 (1988): 223-8

6. Naber KG, Sorgel F, Gutzler F, Bartosik-Wich B "In vitro activity, pharmacokinetics, clinical safety and therapeutic efficacy of enoxacin in the treatment of patients with complicated urinary tract infections." Infection 23 (1985): 219-24

7. Edlund C, Lidbeck A, Kager L, Nord CE "Effect of enoxacin on colonic microflora of healthy volunteers." Eur J Clin Microbiol 6 (1987): 298-300

8. Just PM "Overview of the fluoroquinolone antibiotics." Pharmacotherapy 13 (1993): s4-17

9. "Product Information. Penetrex (enoxacin)." Rhone-Poulenc Rorer, Collegeville, PA.

10. Tsuei SE, Darragh AS, Brick I "Pharmacokinetics and tolerance of enoxacin in healthy volunteers administered at a dosage of 400 mg twice daily for 14 days." J Antimicrob Chemother 14 (1984): 71-4

11. Edlund C, Lidbeck A, Kager L, Nord CE "Comparative effects of enoxacin and norfloxacin on human colonic microflora." Antimicrob Agents Chemother 31 (1987): 1846-8

12. Kang JS, Kim TH, Park KB, Chung BH, Youn JI "Enoxacin photosensitivity." Photodermatol Photoimmunol Photomed 9 (1993): 159-61

13. Kawabe Y, Mizuno N, Sakakibara S "Photoallergic reaction caused by enoxacin." Photodermatol 6 (1989): 58-60

14. Petri H, Tronnier H "Efficacy of enoxacin in the treatment of bacterial infections of the skin with regards to photosensitization." Infection 14 (1986): s213-16

15. Amitrano L, Gigliotti T, Guardascione MA, Ascione A "Acute cholestatic liver injury induced by enoxacin." J Hepatol 18 (1993): 139-40

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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