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Emend Side Effects

Generic Name: aprepitant

Note: This document contains side effect information about aprepitant. Some of the dosage forms listed on this page may not apply to the brand name Emend.

For the Consumer

Applies to aprepitant: oral capsule, oral powder for suspension

Other dosage forms:

Along with its needed effects, aprepitant (the active ingredient contained in Emend) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aprepitant:

Less Common

  • Black or tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence Not Known

  • Blistering, peeling, or loosening of the skin
  • confusion about identity, place, and time
  • diarrhea
  • itching or skin rash
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness of the skin
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • slow or irregular heartbeat

Some side effects of aprepitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Acid or sour stomach
  • belching
  • confusion
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • heartburn
  • hiccups
  • increase in heart rate
  • indigestion
  • lack or loss of strength
  • lightheadedness
  • loss of appetite
  • nausea
  • rapid breathing
  • stomach discomfort upset or pain
  • sunken eyes
  • swelling or inflammation of the mouth
  • thirst
  • weight loss
  • wrinkled skin

Less Common

  • Burning feeling in the chest or stomach
  • hot flashes
  • indigestion
  • pain or discomfort in the chest, upper stomach, or throat
  • tenderness in the stomach area

For Healthcare Professionals

Applies to aprepitant: intravenous emulsion, oral capsule, oral kit, oral powder for reconstitution

General

The most commonly reported side effects included fatigue, neutropenia, constipation, and pruritus.[Ref]

Other

Very common (10% or more): Fatigue (up to 13%)

Common (1% to 10%): Asthenia, pyrexia

Uncommon (0.1% to 1%): Malaise

Rare (0.01% to 0.1%): Candidiasis, staphylococcal infection, tinnitus

Frequency not reported: Hypothermia, pain, postoperative infection, wound dehiscence[Ref]

Hematologic

Very common (10% or more): Neutropenia (up to 13%)

Common (1% to 10%): Anemia, hemoglobin decreased, white blood cell count decreased

Uncommon (0.1% to 1%): Febrile neutropenia

Rare (0.01% to 0.1%): Neutrophil count decreased

Frequency not reported: Blood albumin decreased, thrombocytopenia[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, eructation, flatulence, nausea, vomiting

Uncommon (0.1% to 1%): Dry mouth, gastroesophageal reflux disease

Rare (0.01% to 0.1%): Abdominal distention, duodenal ulcer perforation, feces hard, neutropenic colitis, stomatitis

Frequency not reported: Abdominal pain upper, bowel sounds abnormal, gastritis, oral candidiasis, stomach discomfort, subileus[Ref]

Cardiovascular

Common (1% to 10%): Bradycardia, flushing, hypertension, hypotension

Uncommon (0.1% to 1%): Hot flush, palpitations

Rare (0.01% to 0.1%): Cardiovascular disorder, chest discomfort, edema

Frequency not reported: Blood pressure decreased, edema peripheral, hematoma, operative hemorrhage[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Somnolence

Rare (0.01% to 0.1%): Cognitive disorder, dysgeusia, gait disturbance, lethargy

Frequency not reported: Dysarthria, hypoesthesia, peripheral neuropathy, sensory disturbance, syncope

Postmarketing reports: Ifosfamide-induced neurotoxicity[Ref]

Hepatic

Common (1% to 10%): ALT increased, AST increased

Uncommon (0.1% to 1%): Blood alkaline phosphatase increased

Frequency not reported: Blood bilirubin increased/bilirubin increased[Ref]

Respiratory

Common (1% to 10%): Cough, hiccups

Rare (0.01% to 0.1%): Oropharyngeal pain, postnasal drip, sneezing, throat irritation

Frequency not reported: Dyspnea, hypoxia, pharyngitis, respiratory depression, wheezing[Ref]

Metabolic

Common (1% to 10%): Decreased appetite, dehydration

Rare (0.01% to 0.1%): Blood sodium decreased, polydipsia, weight decreased

Frequency not reported: Blood glucose increased, blood potassium decreased/hypokalemia, hypovolemia[Ref]

Dermatologic

Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Acne, rash

Rare (0.01% to 0.1%): Hyperhidrosis, photosensitivity reaction, rash pruritic, seborrhea, skin lesion, Stevens-Johnson syndrome, toxic epidermal necrolysis

Frequency not reported: Alopecia, urticaria[Ref]

Psychiatric

Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Anxiety

Rare (0.01% to 0.1%): Abnormal behavior, agitation, behavior changes, disorientation, euphoric mood[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Dysuria

Rare (0.01% to 0.1%): Pollakiuria, proteinuria, red blood cells urine positive, urine output increased[Ref]

Musculoskeletal

Rare (0.01% to 0.1%): Muscular weakness, muscle spasms

Frequency not reported: Musculoskeletal pain[Ref]

Renal

Rare (0.01% to 0.1%): Glucose urine present

Frequency not reported: Blood urea increased[Ref]

Hypersensitivity

Frequency not reported: Anaphylactic reactions, angioedema, hypersensitivity reactions[Ref]

Ocular

Rare (0.01% to 0.1%): Conjunctivitis

Frequency not reported: Miosis, visual acuity reduced[Ref]

References

1. "Product Information. Emend (aprepitant)." Merck & Company Inc, West Point, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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