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Doral Side Effects

Generic name: quazepam

Medically reviewed by Drugs.com. Last updated on Jan 31, 2022.

Note: This document contains side effect information about quazepam. Some of the dosage forms listed on this page may not apply to the brand name Doral.

In Summary

Common side effects of Doral include: drowsiness. Other side effects include: dizziness, vertigo, insomnia, confusion, and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to quazepam: oral tablet

Warning

Oral route (Tablet)

Warning: Risks From Concomitant Use With Opioids; Abuse, Misuse, and Addiction; and Dependence and Withdrawal ReactionsConcomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.The use of benzodiazepines, including quazepam, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing quazepam and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction.The continued use of benzodiazepines, including quazepam, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of quazepam after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue quazepam or reduce the dosage

Side effects requiring immediate medical attention

Along with its needed effects, quazepam (the active ingredient contained in Doral) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking quazepam:

More common

  • Drowsiness

Less common

Rare

  • Anxiety
  • dry mouth
  • hyperventilation
  • increased muscle spasm
  • irregular heartbeats
  • irritability
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • nightmares
  • restlessness
  • shaking
  • trouble breathing
  • unusual excitement, nervousness, restlessness, or irritability

Incidence not known

  • Changes in patterns and rhythms of speech
  • chills
  • clay-colored stools
  • dark urine
  • decrease in frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • fever
  • headache
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • itching or rash
  • loss of appetite
  • loss of bladder control
  • nausea
  • painful urination
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • slurred speech
  • sticking out of the tongue
  • stomach pain
  • trembling or shaking of the hands or feet
  • trouble in speaking or swallowing
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unpleasant breath odor
  • unusual facial expressions
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking quazepam:

Symptoms of overdose

  • Change in consciousness
  • loss of consciousness
  • mood or mental changes
  • sleepiness or unusual drowsiness

Side effects not requiring immediate medical attention

Some side effects of quazepam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

  • Decreased interest in sexual intercourse
  • inability to have or keep an erection
  • increase in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • loss in sexual ability, desire, drive, or performance
  • menstrual changes
  • sweating
  • vomiting

For Healthcare Professionals

Applies to quazepam: oral tablet

General

The most frequently reported side effects included daytime drowsiness, headache, fatigue, dizziness, dry mouth, and dyspepsia.

Nervous system

Very common (10% or more): Daytime drowsiness (up to 12%)

Common (1% to 10%): Dizziness, fatigue, headache

Frequency not reported: Central nervous system effects, next-day impairment[Ref]

Gastrointestinal

Common (1% to 10%): Dry mouth, dyspepsia[Ref]

Psychiatric

Frequency not reported: Abnormal thinking, behavior changes, benzodiazepine withdrawal syndrome, complex behaviors, worsening of depression

References

1. "Product Information. Doral (quazepam)." Wallace Laboratories (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.