Skip to main content

Dolobid Side Effects

Generic name: diflunisal

Medically reviewed by Drugs.com. Last updated on Mar 14, 2024.

Note: This document provides detailed information about Dolobid Side Effects associated with diflunisal. Some dosage forms listed on this page may not apply specifically to the brand name Dolobid.

Applies to diflunisal: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Cardiovascular Thrombotic Events. Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal.

This risk may occur early in treatment and may increase with duration of use.

Diflunisal tablets are contraindicated in the setting of coronary artery bypass graft (CABG) surgery Gastrointestinal RiskNSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

These events can occur at any time during use and without warning symptoms.

Elderly patients are at greater risk for serious gastrointestinal events.

Serious side effects of Dolobid

Along with its needed effects, diflunisal (the active ingredient contained in Dolobid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking diflunisal:

More common side effects

  • stomach cramps or pain

Less common side effects

  • back or leg pains
  • bleeding gums
  • blistering, peeling, loosening of skin
  • bloody or black, tarry stools
  • bloody or cloudy urine
  • blurred or loss of vision
  • burning feeling in chest or stomach
  • burning while urinating
  • clay-colored stools
  • constipation
  • cough or hoarseness
  • cracks in the skin
  • dark-colored urine
  • diarrhea
  • difficult or painful urination
  • difficulty breathing
  • difficulty swallowing
  • disturbed color perception
  • dizziness
  • double vision
  • facial swelling
  • fast heartbeat
  • feeling of warmth
  • fever with or without chills
  • flu-like symptoms
  • general body swelling
  • greatly decreased frequency of urination or amount of urine
  • halos around lights
  • headache
  • hives, itching, skin rash
  • increased blood pressure
  • increased thirst
  • indigestion
  • joint or muscle pain
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
  • light-colored stools
  • loss of appetite
  • loss of heat from the body
  • lower back or side pain
  • muscle aches, pains, or weakness
  • nausea or vomiting
  • night blindness
  • noisy breathing
  • nosebleeds
  • overbright appearance of lights
  • pale skin
  • pinpoint red spots on skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red, irritated eyes
  • redness of the face, neck, arms and occasionally, upper chest
  • red skin lesions, often with a purple center
  • red, swollen skin
  • scaly skin
  • severe or continuing stomach pain
  • sores, ulcers, or white spots in mouth or on lips
  • sore throat
  • stomach upset, tenderness
  • swelling of the face, fingers, feet or lower legs
  • swollen lymph nodes
  • tightness in chest
  • trouble breathing
  • tunnel vision
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right stomach pain
  • vomiting of blood or material that looks like coffee grounds
  • weight gain
  • yellow eyes or skin

Symptoms of overdose

Other side effects of Dolobid

Some side effects of diflunisal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • stomach discomfort or upset

Less common side effects

  • bloated, full feeling
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • discouragement
  • dry mucous membranes
  • excess air or gas in stomach or intestines
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • increased sensitivity of skin to sunlight
  • irritability
  • lack or loss of strength
  • lightheadedness
  • loss of interest or pleasure
  • mood or mental changes
  • nervousness
  • passing gas
  • seeing, hearing, or feeling things that are not there
  • sensation of spinning
  • severe sunburn
  • sleeplessness
  • swelling or inflammation of the mouth
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unable to sleep
  • weight loss

For healthcare professionals

Applies to diflunisal: compounding powder, oral tablet.

General adverse events

The most frequently reported side effects were gastrointestinal in nature and included nausea, vomiting, dyspepsia, gastrointestinal pain, diarrhea, constipation, and flatulence.[Ref]

Gastrointestinal

Cardiovascular

Nervous system

Dermatologic

Hematologic

Hepatic

Renal

Hypersensitivity

Other

Metabolic

Psychiatric

Musculoskeletal

Ocular

Respiratory

Genitourinary

Immunologic

References

1. (2001) "Product Information. Dolobid (diflunisal)." Merck & Co., Inc

2. MHRA. Medicines and Health Regulatory Agency (2013) MHRA Drug Safety Update. http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate

Further information

Dolobid side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.