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Dicloxacillin Side Effects

For the Consumer

Applies to dicloxacillin: oral capsules

Side effects include:

GI effects (nausea, vomiting, epigastric distress, loose stools, diarrhea, flatulence); hypersensitivity reactions.

For Healthcare Professionals

Applies to dicloxacillin: oral capsule, oral powder for reconstitution


Gastrointestinal side effects have included nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, epigastric discomfort, flatulence, loose stools, and pseudomembranous colitis.[Ref]


Hematologic side effects have included neutropenia, leukopenia, and thrombocytopenia. Other penicillins have been associated with agranulocytosis and bone marrow depression.[Ref]


Hepatic side effects have included transient changes in SGOT, hepatotoxicity, and cholestatic hepatitis. Serum transaminase levels may take several weeks to return to normal following discontinuation of therapy.[Ref]


Hypersensitivity reactions have included rash, fever, eosinophilia, pruritus, urticaria, angioneurotic edema, anaphylactic reactions (bronchospasm, hypotension, vascular collapse, death), laryngeal edema, laryngospasm, serum-sickness-like symptoms, fever, chills and myalgias.[Ref]


Renal side effects have rarely included renal failure. Increases in serum creatinine and acute renal failure have been reported with higher doses (3 to 4 grams daily) using an intravenous formulation, in postoperative patients with advanced age. Other penicillins have been associated with renal tubular damage and interstitial nephritis (rash, fever, eosinophilia, hematuria, proteinuria, renal insufficiency).[Ref]


1. "Product Information. Dynapen (dicloxacillin)." Apothecon Inc, Plainsboro, NJ.

2. Kleinman MS, Presberg JE "Cholestatic hepatitis after dicloxacillin-sodium therapy." J Clin Gastroenterol 8 (1986): 77-8

3. Olsson R, Wiholm BE, Sand C, Zettergren L, Hultcrantz R, Myrhed M "Liver damage drom flucloxacillin, cloxacillin and dicloxacillin." J Hepatol 15 (1992): 154-61

4. Siegmund JB, Tarshis AM "Prolonged jaundice after dicloxacillin therapy." Am J Gastroenterol 88 (1993): 1299-300

5. Saab S, Venkataramani A, Yao F "Possible granulomatous hepatitis after dicloxacillin therapy." J Clin Gastroenterol 22 (1996): 163-4

6. Shelley WB, Shelley ED "Shoreline nails: sign of drug-induced erythroderma." Cutis Mar (1985): 220-2

7. Wahlstrom O, Maller R, Larsson R, Kagedal B "Effects of hip arthroplasty and peroperative dicloxacillin prophylaxis on renal function." Scand J Infect Dis 24 (1992): 85-8

8. Isacson J, Collert S "Renal impairment after high doses of dicloxacillin-prophylaxis in joint replacement surgery." Acta Orthop Scand 55 (1984): 407-10

9. Nordbring F "Is dicloxacillin nephrotoxic." Acta Orthop Scand 55 (1984): 405-6

Some side effects of dicloxacillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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