Dextromethorphan / Phenylephrine / Pyrilamine Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 21, 2024.

Applies to dextromethorphan / phenylephrine / pyrilamine: oral liquid.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• dizziness;

• nervousness; or

• sleep problems (insomnia).

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to dextromethorphan/phenylephrine/pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral syrup, oral tablet chewable, oral tablet chewable extended release.

Cardiovascular adverse events

Cardiovascular side effects including arrhythmias, hypertension, hypotension, and palpitations have been reported.^[Ref]

Nervous system

Nervous system side effects including coordination disturbances, drowsiness, dysphoria, euphoria, headache, insomnia, irritability, nervousness, sedation, and seizures have been reported.^[Ref]

Dermatologic

Dermatologic side effects including photosensitivity, pruritus, rash, and urticaria have been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects including constipation, diarrhea, epigastric discomfort, nausea, vomiting, and xerostomia have been reported.^[Ref]

Genitourinary

Genitourinary side effects including difficult urination and urinary frequency have been reported.^[Ref]

Hematologic

Hematologic side effects including agranulocytosis, hemolytic anemia, and thrombocytopenia have been reported.^[Ref]

Musculoskeletal

Neuromuscular side effects including tremor and weakness have been reported.^[Ref]

Ocular

Ocular side effects including visual disturbances have been reported.^[Ref]

Respiratory

Respiratory side effects including shortness of breath and wheezing have been reported.^[Ref]

See also:

Further information

Dextromethorphan/phenylephrine/pyrilamine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer