Dextromethorphan / phenylephrine / pyrilamine Side Effects

For the Consumer

Applies to dextromethorphan / phenylephrine / pyrilamine: oral syrup

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Dizziness.
• Feeling nervous and excitable.
• Not able to sleep.
• Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to dextromethorphan/phenylephrine/pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral syrup, oral tablet chewable, oral tablet chewable extended release

Cardiovascular

Cardiovascular side effects including arrhythmias, hypertension, hypotension, and palpitations have been reported.^[Ref]

Nervous system

Nervous system side effects including coordination disturbances, drowsiness, dysphoria, euphoria, headache, insomnia, irritability, nervousness, sedation, and seizures have been reported.^[Ref]

Dermatologic

Dermatologic side effects including photosensitivity, pruritus, rash, and urticaria have been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects including constipation, diarrhea, epigastric discomfort, nausea, vomiting, and xerostomia have been reported.^[Ref]

Genitourinary

Genitourinary side effects including difficult urination and urinary frequency have been reported.^[Ref]

Hematologic

Hematologic side effects including agranulocytosis, hemolytic anemia, and thrombocytopenia have been reported.^[Ref]

Musculoskeletal

Neuromuscular side effects including tremor and weakness have been reported.^[Ref]

Ocular

Ocular side effects including visual disturbances have been reported.^[Ref]

Respiratory

Respiratory side effects including shortness of breath and wheezing have been reported.^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer