Dextromethorphan / phenylephrine / pyrilamine Side Effects

For the Consumer

Applies to dextromethorphan / phenylephrine / pyrilamine: chewable tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; upset stomach; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

For Healthcare Professionals

Applies to dextromethorphan / phenylephrine / pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral syrup, oral tablet chewable, oral tablet chewable extended release

Cardiovascular

Cardiovascular side effects including arrhythmias, hypertension, hypotension, and palpitations have been reported.^[Ref]

Nervous system

Nervous system side effects including coordination disturbances, drowsiness, dysphoria, euphoria, headache, insomnia, irritability, nervousness, sedation, and seizures have been reported.^[Ref]

Dermatologic

Dermatologic side effects including photosensitivity, pruritus, rash, and urticaria have been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects including constipation, diarrhea, epigastric discomfort, nausea, vomiting, and xerostomia have been reported.^[Ref]

Genitourinary

Genitourinary side effects including difficult urination and urinary frequency have been reported.^[Ref]

Hematologic

Hematologic side effects including agranulocytosis, hemolytic anemia, and thrombocytopenia have been reported.^[Ref]

Musculoskeletal

Neuromuscular side effects including tremor and weakness have been reported.^[Ref]

Ocular

Ocular side effects including visual disturbances have been reported.^[Ref]

Respiratory

Respiratory side effects including shortness of breath and wheezing have been reported.^[Ref]

Not all side effects for dextromethorphan / phenylephrine / pyrilamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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