Dextromethorphan / Phenylephrine / Pyrilamine Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 21, 2024.
Applies to dextromethorphan / phenylephrine / pyrilamine: oral liquid.
Important warnings
This medicine can cause some serious health issues
Do not use this medicine if you are using or if you have used an MAO inhibitor in the past 14 days.
A dangerous drug interaction could occur.
MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
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dizziness;
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nervousness; or
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sleep problems (insomnia).
Less serious side effects may be more likely, and you may have none at all.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
See also:
For healthcare professionals
Applies to dextromethorphan/phenylephrine/pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral syrup, oral tablet chewable, oral tablet chewable extended release.
Cardiovascular adverse events
Cardiovascular side effects including arrhythmias, hypertension, hypotension, and palpitations have been reported.[Ref]
Nervous system
Nervous system side effects including coordination disturbances, drowsiness, dysphoria, euphoria, headache, insomnia, irritability, nervousness, sedation, and seizures have been reported.[Ref]
Dermatologic
Dermatologic side effects including photosensitivity, pruritus, rash, and urticaria have been reported.[Ref]
Gastrointestinal
Gastrointestinal side effects including constipation, diarrhea, epigastric discomfort, nausea, vomiting, and xerostomia have been reported.[Ref]
Genitourinary
Genitourinary side effects including difficult urination and urinary frequency have been reported.[Ref]
Hematologic
Hematologic side effects including agranulocytosis, hemolytic anemia, and thrombocytopenia have been reported.[Ref]
Musculoskeletal
Neuromuscular side effects including tremor and weakness have been reported.[Ref]
Ocular
Ocular side effects including visual disturbances have been reported.[Ref]
Respiratory
Respiratory side effects including shortness of breath and wheezing have been reported.[Ref]
References
1. (2003) "Product Information. Viravan-DM (dextromethorphan / phenylephrine / pyrilamine)." PediaMed Pharmaceuticals Inc
2. (2005) "Product Information. Codal-DM Syrup (dextromethorphan / phenylephrine / pyrilamine)." Cypress Pharmaceutical Inc (a division of Currax Pharmaceuticals)
More about dextromethorphan / phenylephrine / pyrilamine
- Check interactions
- Compare alternatives
- Reviews (2)
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Patient resources
- Dextromethorphan, phenylephrine, and pyrilamine drug information
- Phenylephrine/Pyrilamine/Dextromethorphan Syrup
Other brands
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Further information
Dextromethorphan/phenylephrine/pyrilamine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.