Dexilant Side Effects

Generic name: dexlansoprazole

Medically reviewed by Drugs.com. Last updated on Nov 2, 2024.

Note: This document provides detailed information about Dexilant.

Applies to dexlansoprazole: oral capsule delayed release Side Effects associated with dexlansoprazole. Some dosage forms listed on this page may not apply specifically to the brand name Dexilant.

Applies to dexlansoprazole: oral capsule delayed release.

Precautions

It is important that your doctor check your or your child's progress at regular visits. This will allow your doctor to see if this medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects.

Do not take this medicine if you are also using products that contain rilpivirine (Complera®, Edurant®). Using these medicines together may cause unwanted side effects.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Check with your doctor right away if you or your child has a change in frequency of urination or amount of urine, blood in the urine, fever, joint pain, loss of appetite, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or unusual weight gain after receiving this medicine. These could be symptoms of a serious kidney problem called acute tubulointerstitial nephritis.

Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency.

Serious stomach conditions may occur while taking this medicine. Check with your doctor immediately if you or your child has stomach cramps, bloated feeling, watery and severe diarrhea which may also be bloody sometimes, fever, nausea or vomiting, or unusual tiredness or weakness.

Dexlansoprazole may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of this medicine, or use it for one year or more. Call your doctor right away if you have severe bone pain or are unable to walk or sit normally.

Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.

This medicine may cause serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS). Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are taking this medicine for more than 1 year, or if you are taking this medicine together with digoxin (Lanoxin®) or certain diuretics (water pills). Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.

This medicine may increase your risk for fundic gland polyps (abnormal tissue growth in the upper part of your stomach). This is more likely if you are receiving this medicine for more than 1 year. Talk to your doctor if you have concerns.

Do not Stop taking dexlansoprazole (the active ingredient contained in Dexilant) without first checking with your doctor, or unless told to do so by your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before you have medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, atazanavir, nelfinavir, Reyataz®, Viracept®) or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Serious side effects of Dexilant

Along with its needed effects, dexlansoprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dexlansoprazole:

Other side effects of Dexilant

Some side effects of dexlansoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to dexlansoprazole: oral delayed release capsule.

General adverse events

The most commonly reported adverse reactions included diarrhea, abdominal pain, and nausea.^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, diarrhea, flatulence, nausea, vomiting
• Frequency not reported: Abdominal discomfort, abdominal tenderness, abnormal feces, anal discomfort, Barrett's esophagus, bezoar, bowel sounds abnormal, breath odor, Clostridium difficile-associated diarrhea, colitis microscopic, colonic polyp, constipation, dry mouth, duodenitis, dyspepsia, dysphagia, enteritis, eructation, esophagitis, fundic gland polyps, gastric polyp, gastritis, gastroenteritis, gastrointestinal disorders, gastrointestinal hypermotility disorders, GERD, GI ulcers and perforation, hematemesis, hematochezia, hemorrhoids, impaired gastric emptying, irritable bowel syndrome, mucus stools, oral herpes, oral mucosal blistering, oropharyngeal pain, painful defecation, proctitis, paresthesia oral, rectal hemorrhage, rectal tenesmus, retching
• Postmarketing reports: Oral edema, pancreatitis^[Ref]

Respiratory

• Common (1% to 10%): Upper respiratory tract infection
• Frequency not reported: Influenza, nasopharyngitis, oral herpes, pharyngitis, sinusitis, aspiration, asthma, bronchitis, cough, dysphonia, hiccups, hyperventilation, respiratory tract congestion, sore throat, epistaxis, tonsillitis, dyspnea
• Postmarketing reports: Pharyngeal edema, throat tightness^[Ref]

Other

• Frequency not reported: Adverse drug reaction, asthenia, chills, ear pain, falls, feeling abnormal, inflammation, mucosal inflammation, nodule, overdose, pain, procedural pain, pyrexia, tinnitus
• Postmarketing reports: Deafness^[Ref]

Metabolic

• Frequency not reported: Appetite changes, blood glucose increased, blood potassium increased, central obesity, cyanocobalamin (vitamin B12) deficiency, dehydration, diabetes mellitus, gout, hypercalcemia, hyperlipidemia, hypokalemia, hypomagnesemia, total protein increased, weight increased
• Postmarketing reports: Hyponatremia^[Ref]

Nervous system

• Frequency not reported: Altered taste, convulsion, dizziness, headaches, migraine, memory impairment, paresthesia, psychomotor hyperactivity, restless legs syndrome, somnolence, tremor, trigeminal neuralgia, vertigo
• Postmarketing reports: Cerebrovascular accident, transient ischemic attack^[Ref]

Cardiovascular

• Frequency not reported: Angina, arrhythmia, bradycardia, chest pain, deep vein thrombosis, edema, heart valve thickening risk, hot flush, hypertension, myocardial infarction, palpitation, tachycardia^[Ref]

Dermatologic

• Frequency not reported: Acne, cutaneous lupus erythematosus, dermatitis, erythema, folliculitis, pruritus, rash, skin lesion, sunburn, urticaria
• Postmarketing reports: Exfoliative dermatitis, facial edema, generalized rash, leukocytoclastic vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (some fatal)^[Ref]

Hepatic

• Frequency not reported: Acute cholecystitis, ALP increased, ALT increased, AST increased, biliary colic, bilirubin decreased/increased, cholelithiasis, hepatomegaly, liver function test abnormal
• Postmarketing reports: Drug-induced hepatitis^[Ref]

Musculoskeletal

• Frequency not reported: Arthralgia, arthritis, bone fracture/fractures, bursitis, joint sprains, muscle cramps, musculoskeletal pain, myalgia, systemic lupus erythematosus^[Ref]

Genitourinary

• Frequency not reported: Dysmenorrhea, dyspareunia, dysuria, menorrhagia, menstrual disorder, micturition urgency, vulvovaginal infection

Hematologic

• Frequency not reported: Anemia, increased neutrophils, lymphadenopathy, mean corpuscular hemoglobin concentration (MCHC) decreased, neutropenia, platelet count decreased
• Postmarketing reports: Autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura^[Ref]

Psychiatric

• Frequency not reported: Abnormal dreams, anxiety, auditory hallucinations, depression, insomnia, libido changes^[Ref]

Immunologic

• Frequency not reported: Candida infections, herpes zoster, influenza, viral infection^[Ref]

Endocrine

• Frequency not reported: Blood gastrin increased, goiter, hypothyroidism^[Ref]

Hypersensitivity

• Frequency not reported: Anaphylaxis, hypersensitivity
• Postmarketing reports: Anaphylactic shock (requiring emergency intervention)

Renal

• Common (1% to 10%): Upper respiratory tract infection
• Frequency not reported: Aspiration, asthma, bronchitis, cough, dysphonia, dyspnea, epistaxis, hiccups, hyperventilation, nasopharyngitis, pharyngitis, respiratory tract congestion, sinusitis, sore throat, tonsillitis
• Postmarketing reports: Pharyngeal edema, throat tightness^[Ref]

Ocular

• Frequency not reported: Eye irritation, eye swelling
• Postmarketing reports: Blurred vision^[Ref]

Oncologic

• Frequency not reported: B-cell lymphoma

See also:

Further information

Dexilant side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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