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Dexilant Side Effects

Generic Name: dexlansoprazole

Note: This page contains information about the side effects of dexlansoprazole. Some of the dosage forms included on this document may not apply to the brand name Dexilant.

For the Consumer

Applies to dexlansoprazole: oral capsule delayed release, oral tablet disintegrating delayed release

In addition to its needed effects, some unwanted effects may be caused by dexlansoprazole (the active ingredient contained in Dexilant). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dexlansoprazole:

Less common:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • continuing stomach pain
  • diarrhea
  • difficult or labored breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • headache
  • incoherent speech
  • joint pain, stiffness, or swelling
  • lightheadedness, dizziness, or fainting
  • muscle pain, cramps, or weakness
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, leg, back, or neck
  • pounding in the ears
  • rash or hives
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • unusual bleeding or bruising
  • vomiting of blood or material that looks like coffee grounds
  • watery or bloody diarrhea
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • chills
  • cough
  • drowsiness
  • muscle spasms (tetany) or twitching
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the body, feet, or ankles
  • trembling
  • unusual weight gain

Minor Side Effects

Some of the side effects that can occur with dexlansoprazole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Abnormal dreams
  • body aches or pain
  • bloated or full feeling
  • burning or itching around the anus
  • change in taste or bad, unusual, or unpleasant (after) taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficult or painful urination
  • difficulty with moving
  • ear congestion
  • ear pain
  • excess air or gas in the stomach or intestines
  • falls
  • feeling of constant movement of self or surroundings
  • loss in sexual ability, desire, drive, or performance
  • loss of voice
  • metallic taste
  • muscle or bone pain
  • nasal congestion
  • passing gas
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sensation of spinning
  • sneezing
  • sore throat
  • sunburn
  • trouble sleeping

For Healthcare Professionals

Applies to dexlansoprazole: oral delayed release capsule


-The most commonly reported adverse reactions were diarrhea, abdominal pain, nausea, upper respiratory tract infection, vomiting, and flatulence.
-The most common adverse reaction leading to discontinuation of therapy was diarrhea.[Ref]


Frequency not reported: Angina, arrhythmia, bradycardia, chest pain, edema, myocardial infarction, palpitation, tachycardia, deep vein thrombosis, hot flush, hypertension[Ref]


Frequency not reported: Acne, dermatitis, erythema, pruritus, rash, skin lesion, urticaria
Postmarketing reports: Generalized rash, leukocytoclastic vasculitis[Ref]


Frequency not reported: Goiter, diabetes mellitus, hypothyroidism[Ref]


Common (1% to 10%): Diarrhea, abdominal pain, nausea, vomiting, flatulence
Frequency not reported: Abdominal discomfort, abdominal tenderness, abnormal feces, anal discomfort, Barrett's esophagus, bezoar, bowel sounds abnormal, breath odor, colitis microscopic, colonic polyp, constipation, dry mouth, duodenitis, dyspepsia, dysphagia, enteritis, eructation, esophagitis, gastric polyp, gastritis, gastroenteritis, gastrointestinal disorders, gastrointestinal hypermotility disorders, GERD, GI ulcers and perforation, hematemesis, hematochezia, hemorrhoids, impaired gastric emptying, irritable bowel syndrome, mucus stools, oral mucosal blistering, painful defecation, proctitis, paresthesia oral, rectal hemorrhage, retching
Postmarketing reports: Oral edema, pancreatitis, clostridium difficile associated diarrhea, rectal tenesmus[Ref]


Frequency not reported: Vulvo-vaginal infection, dysuria, micturition urgency, dysmenorrhea, dyspareunia, menorrhagia, menstrual disorder


Frequency not reported: Anemia, lymphadenopathy, blood creatinine increased, blood gastrin increased, blood glucose increased, blood potassium increased, mean corpuscular hemoglobin concentration (MCHC) decreased, neutropenia
Postmarketing reports: Autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura[Ref]


Frequency not reported: Biliary colic, cholelithiasis, hepatomegaly, ALP increased, ALT increased, AST increased, bilirubin decreased/increased, liver function test abnormal
Postmarketing reports: Drug-induced hepatitis[Ref]


Frequency not reported: Hypersensitivity, anaphylaxis
Postmarketing reports: Anaphylactic shock (requiring emergency intervention), exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (some fatal)


Frequency not reported: Total protein increased, weight increased, appetite changes, hypercalcemia, hypokalemia, central obesity, cholecystitis acute, dehydration, hyperlipidemia
Postmarketing reports: Hypomagnesemia, hyponatremia[Ref]


Frequency not reported: Fractures, joint sprains, arthralgia, arthritis, muscle cramps, musculoskeletal pain, myalgia, bursitis
Postmarketing reports: Bone fracture[Ref]

Nervous system

Frequency not reported: Altered taste, convulsion, dizziness, headaches, migraine, memory impairment, paresthesia, psychomotor hyperactivity, tremor, trigeminal neuralgia, restless legs syndrome, somnolence
Postmarketing reports: Cerebrovascular accident, transient ischemic attack[Ref]


Frequency not reported: Eye irritation, eye swelling
Postmarketing reports: Blurred vision[Ref]


Frequency not reported: B-cell lymphoma


Frequency not reported: Ear pain, tinnitus, vertigo, asthenia, chest pain, chills, feeling abnormal, inflammation, mucosal inflammation, nodule, pain, pyrexia, candida infections, viral infections, overdose, procedural pain, sunburn, falls, auditory hallucinations, folliculitis, herpes zoster
Postmarketing reports: Facial edema, deafness[Ref]


Frequency not reported: Abnormal dreams, anxiety, depression, insomnia, libido changes[Ref]


Postmarketing reports: Acute renal failure[Ref]


Common (1% to 10%): Upper respiratory tract infection
Frequency not reported: Influenza, nasopharyngitis, oral herpes, pharyngitis, sinusitis, aspiration, asthma, bronchitis, cough, dysphonia, hiccups, hyperventilation, respiratory tract congestion, sore throat, epistaxis, tonsillitis, dyspnea
Postmarketing reports: Pharyngeal edema, throat tightness[Ref]


1. "Product Information. Kapidex (dexlansoprazole)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Not all side effects for Dexilant may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.