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Dexilant Side Effects

Generic name: dexlansoprazole

Medically reviewed by Last updated on Mar 20, 2024.

Note: This document contains side effect information about dexlansoprazole. Some dosage forms listed on this page may not apply to the brand name Dexilant.

Applies to dexlansoprazole: oral capsule delayed release.

Serious side effects of Dexilant

Along with its needed effects, dexlansoprazole (the active ingredient contained in Dexilant) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dexlansoprazole:

Less common

Incidence not known

Other side effects of Dexilant

Some side effects of dexlansoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to dexlansoprazole: oral delayed release capsule.


The most commonly reported adverse reactions included diarrhea, abdominal pain, and nausea.[Ref]


Common (1% to 10%): Abdominal pain, diarrhea, flatulence, nausea, vomiting

Frequency not reported: Abdominal discomfort, abdominal tenderness, abnormal feces, anal discomfort, Barrett's esophagus, bezoar, bowel sounds abnormal, breath odor, Clostridium difficile-associated diarrhea, colitis microscopic, colonic polyp, constipation, dry mouth, duodenitis, dyspepsia, dysphagia, enteritis, eructation, esophagitis, fundic gland polyps, gastric polyp, gastritis, gastroenteritis, gastrointestinal disorders, gastrointestinal hypermotility disorders, GERD, GI ulcers and perforation, hematemesis, hematochezia, hemorrhoids, impaired gastric emptying, irritable bowel syndrome, mucus stools, oral herpes, oral mucosal blistering, oropharyngeal pain, painful defecation, proctitis, paresthesia oral, rectal hemorrhage, rectal tenesmus, retching

Postmarketing reports: Oral edema, pancreatitis[Ref]


Common (1% to 10%): Upper respiratory tract infection

Frequency not reported: Influenza, nasopharyngitis, oral herpes, pharyngitis, sinusitis, aspiration, asthma, bronchitis, cough, dysphonia, hiccups, hyperventilation, respiratory tract congestion, sore throat, epistaxis, tonsillitis, dyspnea

Postmarketing reports: Pharyngeal edema, throat tightness[Ref]


Frequency not reported: Adverse drug reaction, asthenia, chills, ear pain, falls, feeling abnormal, inflammation, mucosal inflammation, nodule, overdose, pain, procedural pain, pyrexia, tinnitus

Postmarketing reports: Deafness[Ref]


Frequency not reported: Appetite changes, blood glucose increased, blood potassium increased, central obesity, cyanocobalamin (vitamin B12) deficiency, dehydration, diabetes mellitus, gout, hypercalcemia, hyperlipidemia, hypokalemia, hypomagnesemia, total protein increased, weight increased

Postmarketing reports: Hyponatremia[Ref]

Nervous system

Frequency not reported: Altered taste, convulsion, dizziness, headaches, migraine, memory impairment, paresthesia, psychomotor hyperactivity, restless legs syndrome, somnolence, tremor, trigeminal neuralgia, vertigo

Postmarketing reports: Cerebrovascular accident, transient ischemic attack[Ref]


Frequency not reported: Angina, arrhythmia, bradycardia, chest pain, deep vein thrombosis, edema, heart valve thickening risk, hot flush, hypertension, myocardial infarction, palpitation, tachycardia[Ref]


Frequency not reported: Acne, cutaneous lupus erythematosus, dermatitis, erythema, folliculitis, pruritus, rash, skin lesion, sunburn, urticaria

Postmarketing reports: Exfoliative dermatitis, facial edema, generalized rash, leukocytoclastic vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (some fatal)[Ref]


Frequency not reported: Acute cholecystitis, ALP increased, ALT increased, AST increased, biliary colic, bilirubin decreased/increased, cholelithiasis, hepatomegaly, liver function test abnormal

Postmarketing reports: Drug-induced hepatitis[Ref]


Frequency not reported: Arthralgia, arthritis, bone fracture/fractures, bursitis, joint sprains, muscle cramps, musculoskeletal pain, myalgia, systemic lupus erythematosus[Ref]


Frequency not reported: Dysmenorrhea, dyspareunia, dysuria, menorrhagia, menstrual disorder, micturition urgency, vulvovaginal infection


Frequency not reported: Anemia, increased neutrophils, lymphadenopathy, mean corpuscular hemoglobin concentration (MCHC) decreased, neutropenia, platelet count decreased

Postmarketing reports: Autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura[Ref]


Frequency not reported: Abnormal dreams, anxiety, auditory hallucinations, depression, insomnia, libido changes[Ref]


Frequency not reported: Candida infections, herpes zoster, influenza, viral infection[Ref]


Frequency not reported: Blood gastrin increased, goiter, hypothyroidism[Ref]


Frequency not reported: Anaphylaxis, hypersensitivity

Postmarketing reports: Anaphylactic shock (requiring emergency intervention)


Common (1% to 10%): Upper respiratory tract infection

Frequency not reported: Aspiration, asthma, bronchitis, cough, dysphonia, dyspnea, epistaxis, hiccups, hyperventilation, nasopharyngitis, pharyngitis, respiratory tract congestion, sinusitis, sore throat, tonsillitis

Postmarketing reports: Pharyngeal edema, throat tightness[Ref]


Frequency not reported: Eye irritation, eye swelling

Postmarketing reports: Blurred vision[Ref]


Frequency not reported: B-cell lymphoma


1. Product Information. Kapidex (dexlansoprazole). Takeda Pharmaceuticals America. 2009.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.