Dexchlorpheniramine Side Effects
For the Consumer
Applies to dexchlorpheniramine: controlled-release tablets, syrup
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking dexchlorpheniramine:
Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.
For Healthcare Professionals
Applies to dexchlorpheniramine: compounding powder, oral syrup, oral tablet, oral tablet extended release
Gastrointestinal side effects have included dryness of mouth and throat, epigastric distress, anorexia, nausea, vomiting, diarrhea, and constipation.[Ref]
Genitourinary side effects have included urinary frequency, difficult urination, urinary frequency, and early menses.[Ref]
Hypersensitivity reactions have included drug rash, anaphylactic shock, and photosensitivity.[Ref]
Dermatologic side effects have included urticaria.[Ref]
General side effects have included excessive perspiration, chills, and dryness of nose.[Ref]
Hematologic side effects have included hemolytic anemia, thrombocytopenia, and agranulocytosis.[Ref]
Nervous system side effects have included sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesias, hysteria, neuritis, and convulsions.[Ref]
Ocular side effects have included blurred vision and diplopia.[Ref]
Otic side effects have included vertigo, tinnitus, and acute labyrinthitis.[Ref]
Respiratory side effects have included thickening of bronchial secretions, tightness of chest, wheezing, and nasal stiffness.[Ref]
1. "Product Information. Polaramine (dexchlorpheniramine)." Schering-Plough Corporation, Kenilworth, NJ.
2. Theunissen EL, Vermeeren A, Ramaekers JG "Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance." Br J Clin Pharmacol 61 (2006): 79-86
Not all side effects for dexchlorpheniramine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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