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Desyrel Dividose Side Effects

Generic Name: trazodone

Note: This page contains information about the side effects of trazodone. Some of the dosage forms included on this document may not apply to the brand name Desyrel Dividose.

For the Consumer

Applies to trazodone: oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by trazodone (the active ingredient contained in Desyrel Dividose). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking trazodone:

More common:
  • Blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • lightheadedness
  • sweating
  • unusual tiredness or weakness
Less common:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion about identity, place, and time
  • decreased concentration
  • fainting
  • general feeling of discomfort or illness
  • headache
  • lack of coordination
  • muscle tremors
  • nervousness
  • pounding in the ears
  • shortness of breath
  • slow or fast heartbeat
  • swelling
  • Skin rash
  • unusual excitement

Minor Side Effects

Some of the side effects that can occur with trazodone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Dry mouth (usually mild)
  • muscle or bone pain
  • trouble sleeping
  • trouble with remembering
  • unpleasant taste
Less common:
  • Constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • diarrhea
  • hearing loss
  • muscle aches or pains
  • weight loss

For Healthcare Professionals

Applies to trazodone: compounding powder, oral tablet, oral tablet extended release


The most commonly reported side effects were dry mouth, nausea, vomiting, drowsiness, dizziness/light-headedness, headache, and nervousness.[Ref]


Common (1% to 10%): Hypertension, hypotension, syncope, tachycardia, palpitations
Frequency not reported: Sinus bradycardia, chest pain, ventricular couplets
Postmarketing reports: Cardiospasm, cerebrovascular accident, congestive heart failure, vasodilation, conduction block, orthostatic hypotension, atrial fibrillation, myocardial infarction, cardiac arrest, arrhythmia, ventricular ectopic activity, prolonged QT interval, torsade de pointes, ventricular tachycardia[Ref]


Common (1% to 10%): Anger/hostility, excitement, insomnia, nightmares/vivid dreams
Frequency not reported: Hallucinations/delusions, mania/hypomania, impaired speech, suicidal ideation, disorientation, aggressive reaction, withdrawal syndrome
Postmarketing reports: Abnormal dreams, agitation, anxiety, paranoid reaction, psychosis[Ref]

Nervous system

Very common (10% or more): Drowsiness (up to 40.8%), dizziness/light-headedness (up to 28%), headache (up to 19.8%), nervousness (up to 14.8%)
Common (1% to 10%): Confusion, decreased concentration, disorientation, impaired memory, incoordination, paresthesia, tremors
Frequency not reported: Akathisia, muscle twitches, numbness, serotonin syndrome, convulsion, neuroleptic malignant syndrome, vertigo, restlessness, decreased alertness, cognitive/motor impairment
Postmarketing reports: Aphasia, ataxia, extrapyramidal symptoms, grand mal seizures, stupor, tardive dyskinesia, myoclonus,[Ref]


Common (1% to 10%): Decreased libido, delayed urine flow, early menses
Frequency not reported: Hematuria, impotence, increased libido, increased urinary frequency, missed periods, retrograde ejaculation
Postmarketing reports: Breast enlargement or engorgement, clitorism, lactation, priapism, urinary incontinence, urinary retention[Ref]


Frequency not reported: Anemia, hemolytic anemia, granulocytosis, thrombocytopenia, eosinophilia, leucopenia
Postmarketing reports: Leukocytosis, methemoglobinemia[Ref]


Common (1% to 10%): Decreased appetite, weigh gain/loss
Frequency not reported: Increased appetite, anorexia, hyponatremia[Ref]


Very common (10% or more): Blurred vision (up to 14.7%)
Common (1% to 10%): Red/tired/itching eyes
Frequency not reported: Angle-closure glaucoma
Postmarketing reports: Diplopia[Ref]


Common (1% to 10%): Sweating/clamminess
Frequency not reported: Hyperhidrosis
Postmarketing reports: Alopecia, leuconychia, pruritus, psoriasis, rash, urticaria[Ref]


Postmarketing reports: Hirsutism, inappropriate ADH syndrome[Ref]


Very common (10% or more): Dry mouth (up to 33.8%), nausea/vomiting (up to 12.7%)
Common (1% to 10%): Constipation, abdominal/gastric disorder, bad taste, diarrhea
Frequency not reported: Flatulence, increased salivation, dyspepsia, stomach pain, gastroenteritis, paralytic ileus
Postmarketing reports: Increased amylase[Ref]


Postmarketing reports: Cholestasis, hyperbilirubinemia, jaundice, liver enzyme alterations[Ref]


Frequency not reported: Allergic reactions[Ref]


Common (1% to 10%): Musculoskeletal aches/pains
Frequency not reported: Limb pain, back pain, myalgia, arthralgia[Ref]


Very common (10% or more): Fatigue (up to 11.3%)
Common (1% to 10%): Edema, malaise, tinnitus
Frequency not reported: Chills, fever
Postmarketing reports: Unexplained death, weakness[Ref]


Common (1% to 10%): Shortness of breath, nasal/sinus congestion
Frequency not reported: Dyspnea
Postmarketing reports: Apnea[Ref]


1. "Product Information. Desyrel (trazodone)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Desyrel Dividose may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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