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Demadex IV Side Effects

Generic Name: torsemide

Note: This page contains information about the side effects of torsemide. Some of the dosage forms included on this document may not apply to the brand name Demadex IV.

For the Consumer

Applies to torsemide: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by torsemide (the active ingredient contained in Demadex IV). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking torsemide, check with your doctor or nurse as soon as possible:

Less common:
  • Chest pain
  • convulsions
  • decreased urination
  • diarrhea
  • dry mouth
  • electrocardiogram (ECG) changes
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in hands, feet, or lips
  • shortness of breath
  • swelling of hands, ankles, feet, or lower legs
  • unusual tiredness or weakness
Rare
  • Black, tarry stools
  • dizziness, faintness, or lightheadedness when getting up from a sitting or lying position suddenly
  • ringing or buzzing in the ears or any hearing loss
  • skin rash

If any of the following symptoms of overdose occur while taking torsemide, get emergency help immediately:

Symptoms of overdose:
  • Blurred vision
  • coma
  • confusion
  • decreased urine output
  • dizziness
  • drowsiness
  • fainting
  • fast heartbeat
  • fatigue
  • headache
  • increase in heart rate
  • irritability
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • sweating
  • weak pulse
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with torsemide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Increase in urination
Less common:
  • Acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • difficulty in moving
  • heartburn
  • increased cough
  • indigestion
  • joint pain
  • lack or loss of strength
  • muscle pain or stiffness
  • nervousness
  • pain in joints
  • runny nose
  • sleeplessness
  • sneezing
  • sore throat
  • stomach discomfort, upset, or pain
  • stuffy nose
  • swollen joints
  • trouble sleeping
  • unable to sleep

For Healthcare Professionals

Applies to torsemide: injectable solution, oral tablet

General

The most common adverse reactions were headache and excessive urination.[Ref]

Metabolic

Common (1% to 10%): Edema
Frequency not reported: Hyperglycemia, hyperuricemia, hypokalemia, hypovolemia, excessive thirst, gout, calcium excretion increased, serum calcium increased, serum calcium decreased, magnesium excretion increased, serum magnesium increased, serum magnesium decreased, BUN increased, creatinine increased, uric acid increased, serum glucose increased, total plasma cholesterol increased, plasma triglycerides increased[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, constipation, nausea, dyspepsia, sore throat
Frequency not reported: Vomiting, esophageal hemorrhage, gastrointestinal hemorrhage, rectal bleeding, dry mouth
Postmarketing reports: Pancreatitis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Frequency not reported: Syncope, tinnitus, hearing loss, limb paresthesia[Ref]

Other

Common (1% to 10%): Asthenia, chest pain
Frequency not reported: Weakness, digitalis intoxication[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, myalgia
Frequency not reported: Arthritis[Ref]

Psychiatric

Common (1% to 10%): Insomnia, nervousness[Ref]

Respiratory

Common (1% to 10%): Rhinitis, cough increased[Ref]

Cardiovascular

Common (1% to 10%): ECG abnormality
Frequency not reported: Atrial fibrillation, hypotension, shunt thrombosis, ventricular tachycardia[Ref]

Genitourinary

Common (1% to 10%): Excessive urination
Frequency not reported: Impotence[Ref]

Hematologic

Frequency not reported: Red blood cells decreased, white blood cells decreased, platelets decreased, hemoglobin decreased, hematocrit decreased, erythrocyte count decreased, white blood cell count increased, platelet count increased, serum alkaline phosphatase increased
Postmarketing reports: Leukopenia, thrombocytopenia[Ref]

Dermatologic

Frequency not reported: Rash, angioedema
Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]

Ocular

Frequency not reported: Visual disturbance[Ref]

References

1. "Product Information. Demedex (torsemide)." Boehringer Mannheim, Gaithersburg, MD.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Demadex IV may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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