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Cefzil Side Effects

Generic name: cefprozil

Medically reviewed by Drugs.com. Last updated on Jun 22, 2023.

Note: This document contains side effect information about cefprozil. Some dosage forms listed on this page may not apply to the brand name Cefzil.

Applies to cefprozil: oral powder for suspension, oral tablet.

Serious side effects of Cefzil

Along with its needed effects, cefprozil (the active ingredient contained in Cefzil) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cefprozil:

Less common

Rare

Incidence not known

Other side effects of Cefzil

Some side effects of cefprozil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Rare

For Healthcare Professionals

Applies to cefprozil: oral powder for reconstitution, oral tablet.

General

Cefprozil (the active ingredient contained in Cefzil) is generally well-tolerated.[Ref]

Hypersensitivity

Hypersensitivity reactions have included rash (0.9%), urticaria (0.1%), anaphylaxis, angioedema, bronchospasm, eosinophilia, erythema multiforme, fever, serum-sickness-like reactions, and Stevens-Johnson syndrome.[Ref]

Up to 20% of patients with penicillin allergy may demonstrate allergy to cefprozil.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea (3.5%), diarrhea (2.9%), vomiting (1%), and abdominal pain (1%). Rare cases of Clostridium difficile colitis have been reported with some cephalosporins.[Ref]

Pseudomembranous colitis has been reported in patients treated with cephalosporin antibiotics. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.[Ref]

Hematologic

Hematologic side effects have included eosinophilia (2.3%), decreased leukocyte count (0.2%), and thrombocytopenia. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, pancytopenia, neutropenia, and agranulocytosis.[Ref]

Renal

Renal side effects have included elevated serum creatinine (0.1%) and BUN (0.1%). Some other cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis.) Cephalosporins as a class have been associated with toxic nephropathy and renal dysfunction.[Ref]

Genitourinary

Genitourinary side effects have included vaginitis and genital pruritus in 1.6% of patients.[Ref]

Hepatic

Hepatic side effects have included increased AST (2%), ALT (2%), alkaline phosphatase (0.2%), and bilirubin (<0.1%). Some cephalosporins have been associated with rare cases of cholestatic jaundice. Cephalosporins as a class have been associated with elevated LDH.[Ref]

Nervous system

Nervous system side effects have included dizziness in 1% of patients, and hyperactivity, headache, nervousness, insomnia, confusion, and somnolence in <1%. Some cephalosporins have been associated with seizures, primarily when dosages were not reduced in renally impaired patients.[Ref]

Other

Other side effects have included superinfection and diaper rash in 1.5% of patients.[Ref]

Dermatologic

Dermatologic side effects have included rash (0.9%), urticaria (0.1%), and erythema multiforme. Cefprozil (the active ingredient contained in Cefzil) has been associated with rash in a patients with infectious mononucleosis.[Ref]

References

1. Wilber RB, Doyle CA, Durham SJ, et al. Safety profile of cefprozil. Clin Infect Dis. 1992;14:s264-71.

2. Multum Information Services, Inc. Expert Review Panel

3. Cefprozil. Med Lett Drugs Ther. 1992;34:63-4.

4. Product Information. Cefzil (cefprozil). Bristol-Myers Squibb. 2002.

5. Filipe P, Almeida RSLS, Rodrigo FG. Occupational allergic contact dermatitis from cephalosporins. Contact Dermatitis. 1996;34:226.

6. Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sanchez F, Perez E, Venuti A, Blanca M. Immediate allergic reactions to cephalosporins: Cross-reactivity and selective responses. J Allerg Clin Immunol. 2000;106:1177-83.

7. Christenson JC, Gooch WM, Herrod JN, Swenson E. Comparative efficacy and safety of cefprozil and cefaclor in the treatment of acute uncomplicated urinary tract infections. J Antimicrob Chemother. 1991;28:581-6.

8. Christenson JC, Swenson E, Gooch WM III, Herrod JN. Comparative efficacy and safety of cefprozil (BMY-28100) and cefaclor in the treatment of acute group A beta-hemolytic streptococcal pharyngitis. Antimicrob Agents Chemother. 1991;35:1127-30.

9. Haskell RJ, Fujita NK, Stevenson JA, Border WA. Cefoxitin-induced interstitial nephritis. Arch Intern Med. 1981;141:1557.

10. Toll LL, Lee M, Sharifi R. Cefoxitin-induced interstitial nephritis. South Med J. 1987;80:274-5.

11. Baciewicz AM, Chandra R. Cefprozil-induced rash in infectious mononucleosis. Ann Pharmacother. 2005;39:974-5.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.