Cefixime Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 21, 2023.
Applies to cefixime: oral capsule, oral powder for suspension.
Serious side effects of Cefixime
Along with its needed effects, cefixime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cefixime:
More common
- Diarrhea
- loose or frequent stools
Less common
- Abdominal or stomach pain
- agitation
- black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- chest pain
- chills
- clay-colored stools
- coma
- confusion
- cough
- dark urine
- decreased urine output
- depression
- difficulty with swallowing
- dizziness
- fast heartbeat
- feeling of discomfort
- fever
- general tiredness and weakness
- headache
- hives, itching, or skin rash
- hostility
- inflammation of the joints
- irritability
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- lethargy
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle aches
- muscle twitching
- nausea and vomiting
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- red skin lesions, often with a purple center
- red, irritated eyes
- seizures
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stupor
- swelling of the face, ankles, or hands
- swollen glands
- swollen lymph glands
- tightness in the chest
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- vomiting of blood
- yellow eyes or skin
Incidence not known
- Abdominal or stomach cramps or tenderness
- back, leg, or stomach pains
- cough or hoarseness
- coughing up blood
- diarrhea, watery and severe, which may also be bloody
- general body swelling
- increased menstrual flow or vaginal bleeding
- increased thirst
- nosebleeds
- paralysis
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- sudden decrease in the amount of urine
- unpleasant breath odor
- unusual weight loss
Other side effects of Cefixime
Some side effects of cefixime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Acid or sour stomach
- belching
- bloated
- excess air or gas in the stomach or intestines
- full feeling
- heartburn
- hives or welts
- indigestion
- itching of the vagina or genital area itching or pain of the genital area
- pain during sexual intercourse
- passing gas
- redness of the skin
- stomach discomfort, upset, or pain
- thick, white vaginal discharge with no odor or with a mild odor
- white patches in the mouth or throat or on the tongue
- white patches with diaper rash
For Healthcare Professionals
Applies to cefixime: oral capsule, oral powder for reconstitution, oral tablet, oral tablet chewable.
General
The most commonly reported side effects included gastrointestinal effects, diarrhea, nausea, and/or frequent/loose stools.[Ref]
Gastrointestinal
Diarrhea more commonly occurred with higher doses. Treatment cessation was occasionally warranted in patients who developed moderate to severe diarrhea. Patients who develop marked diarrhea should discontinue treatment.[Ref]
Very common (10% or more): Gastrointestinal effects (up to 30%), diarrhea (up to 16%)
Common (1% to 10%): abdominal pain, dyspepsia, flatulence, frequent stools, loose stools, nausea
Uncommon (0.1% to 1%): Vomiting
Very rare (less than 0.01%): Antibiotic-associated colitis
Frequency not reported: Marked diarrhea, moderate diarrhea, severe diarrhea, pseudomembranous colitis
Postmarketing reports: Colitis[Ref]
Hepatic
Uncommon (0.1% to 1%): Alkaline phosphatase increased, ALT increased, AST increased, liver enzyme increased
Very rare (less than 0.01%): Cholestatic jaundice, hepatitis
Frequency not reported: Blood bilirubin increased, jaundice
Postmarketing reports: Cholestasis, hyperbilirubinemia, liver dysfunction[Ref]
Dermatologic
Uncommon (0.1% to 1%): Rash/skin rash
Rare (0.01% to 0.1%): Pruritus
Very rare (less than 0.01%): Drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome, toxic epidermal necrolysis
Frequency not reported: Erythema multiforme, face edema, urticaria[Ref]
Nervous system
Uncommon (0.1% to 1%): Headache
Rare (0.01% to 0.1%): Vertigo
Very rare (less than 0.01%): Psychomotor hyperactivity
Frequency not reported: Convulsions, consciousness impaired, dizziness, encephalopathy, movement disorders
Postmarketing reports: Seizures[Ref]
Encephalopathy included confusion, convulsions, impaired consciousness, and/or movement disorders; beta-lactams predispose patients to the risk of this side effect, especially in cases of overdose or renal dysfunction.
Convulsions occurred with cephalosporins.[Ref]
Immunologic
Rare (0.01% to 0.1%): Bacterial superinfection, fungal superinfection
Very rare (less than 0.01%): Serum sickness-like reaction/serum sickness
Postmarketing reports: Candidiasis, superinfection[Ref]
Hypersensitivity
Rare (0.01% to 0.1%): Angioneurotic edema, hypersensitivity
Very rare (less than 0.01%): Anaphylactic shock
Frequency not reported: Anaphylactic reaction/anaphylactoid reaction, angioedema
Postmarketing reports: Allergic reactions, anaphylactic shock, fatal anaphylactic reaction[Ref]
Other
Rare (0.01% to 0.1%): Mucosal inflammation, pyrexia
Very rare (less than 0.01%): Drug fever[Ref]
Hematologic
Rare (0.01% to 0.1%): Eosinophilia
Very rare (less than 0.01%): Agranulocytosis, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia
Frequency not reported: Direct positive Coombs test, granulocytopenia, hypereosinophilia, indirect positive Coombs test, neutropenia, thrombocytosis
Postmarketing reports: Aplastic anemia, prothrombin time prolongation[Ref]
Renal
Tubulointerstitial nephritis was an underlying pathological condition of acute renal failure.[Ref]
Rare (0.01% to 0.1%): Blood urea increased
Very rare (less than 0.01%): Acute renal failure, blood creatinine increased, interstitial nephritis, tubulointerstitial nephritis
Postmarketing reports: Renal dysfunction, toxic nephropathy, transient blood urea nitrogen elevation (BUN)[Ref]
Metabolic
Rare (0.01% to 0.1%): Anorexia[Ref]
Respiratory
Frequency not reported: Dyspnea[Ref]
Musculoskeletal
Frequency not reported: Arthralgia[Ref]
Genitourinary
Frequency not reported: Genital pruritus, vaginitis[Ref]
Cardiovascular
Postmarketing reports: Hemorrhage[Ref]
Endocrine
Postmarketing reports: Elevated lactate dehydrogenase (LDH)[Ref]
Psychiatric
Frequency not reported: Confusion[Ref]
Frequently asked questions
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References
1. Product Information. Suprax (cefixime). Lupin Pharmaceuticals Inc. 2002;PROD.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.