Cardizem CD Side Effects
Generic name: diltiazem
Medically reviewed by Drugs.com. Last updated on May 1, 2022.
Note: This document contains side effect information about diltiazem. Some of the dosage forms listed on this page may not apply to the brand name Cardizem CD.
More frequent side effects include: dizziness, edema, asthenia, headache, and vasodilation. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to diltiazem: oral capsule extended release, oral capsule extended release 12 hr, oral capsule extended release 24 hr, oral tablet, oral tablet extended release, oral tablet extended release 24 hr
Other dosage forms:
Side effects requiring immediate medical attention
Along with its needed effects, diltiazem (the active ingredient contained in Cardizem CD) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking diltiazem:
- Body aches or pain
- dryness or soreness of the throat
- runny nose
- tender or swollen glands in the neck
- trouble swallowing
- voice changes
- Chest pain, discomfort, or tightness
- difficult or labored breathing
- feeling faint, dizzy, or lightheaded
- feeling of warmth or heat
- flushing or redness of the skin, especially on the face and neck
- general feeling of discomfort or illness
- joint pain
- loss of appetite
- muscle aches and pains
- slow or irregular heartbeat
- swelling of the hands, ankles, feet, or lower legs
- trouble sleeping
- unusual tiredness or weakness
Incidence not known
- Blistering, peeling, or loosening of the skin
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- no heartbeat
- red skin lesions, often with a purple center
- red, irritated eyes
- sores, ulcers, or white spots in the mouth or on the lips
Side effects not requiring immediate medical attention
Some side effects of diltiazem may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- stuffy nose
- Acid or sour stomach
- continuing ringing or buzzing or other unexplained noise in the ears
- degenerative disease of the joint
- difficulty with moving
- hearing loss
- lack or loss of strength
- muscle aching or cramping
- muscle pains or stiffness
- pain or tenderness around the eyes and cheekbones
- stomach discomfort, upset, or pain
- swollen joints
Incidence not known
- Loss or thinning of the hair
For Healthcare Professionals
Applies to diltiazem: compounding powder, intravenous powder for injection, intravenous solution, oral capsule extended release, oral tablet, oral tablet extended release
A patient with Prinzmetal's angina developed asystole after a single, 60 mg dose.
Myocardial infarction was not readily distinguishable from the natural history of the disease.
Vasodilatory events (e.g., peripheral edema, headache, flushing) are dose-related and may be more common in elderly patients.
Very common (10% or more): Peripheral edema (up to 15%)
Common (1% to 10%): Arrhythmia (junctional rhythm/isorhythmic dissociation), asymptomatic/symptomatic hypotension, atrioventricular (AV) block (first/second/third degree), bradycardia, bundle branch block, ECG abnormality, edema, extrasystole/ventricular extrasystole, flushing, lower limb edema, palpitations, vasodilation
Uncommon (0.1% to 1%): Orthostatic hypotension
Frequency not reported: Angina, asystole/cardiac arrest, atrial flutter, chest pain, development/aggravation of congestive heart failure, hypotension, sinoatrial block, sinus node dysfunction, sinus pause/arrest, vasculitis, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia/tachycardia
Postmarketing reports: Myocardial infarction, vasodilation symptoms (flushing, lower limb edema, sweating)[Ref]
Common (1% to 10%): Asthenia, fatigue, flu syndrome, infection, malaise, pain
Common (1% to 10%): Abdominal enlargement, constipation, dyspepsia, gastric pain, nausea
Uncommon (0.1% to 1%): Diarrhea, vomiting
Rare (0.01% to 0.1%): Dry mouth
Well-documented cases of rashes (as leukocytoclastic vasculitis) have been reported, but a definitive between these events and this drug have not been established.
Lichenoid keratosis and hyperpigmentation occurred in skin exposed to the sun.[Ref]
Frequency not reported: Acute generalized exanthematous pustular dermatitis, desquamative erythema with/without fever exfoliative dermatitis, facial edema, hyperhidrosis/sweating, hyperpigmentation, leukocytoclastic vasculitis, petechiae, photosensitivity (lichenoid keratosis), pruritus, Steven-Johnson's syndrome
Frequency not reported: Dyspnea, epistaxis
Dizziness occurred more frequently with higher doses.[Ref]
Common (1% to 10%): Dizziness, headache, lightheadedness
Common (1% to 10%): Myalgia
Common (1% to 10%): Gout
Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, mild elevation of alkaline phosphatase, mild elevation of lactate dehydrogenase, thirst, weight increase[Ref]
Common (1% to 10%): Impotence
Frequency not reported: Albuminuria, crystalluria, nocturia, polyuria, sexual difficulties[Ref]
Common (1% to 10%): Conjunctivitis
Common (1% to 10%): Injection site reactions (e.g., itching, burning)[Ref]
Uncommon (0.1% to 1%): Insomnia, nervousness
Uncommon (0.1% to 1%): Increased hepatic enzymes (ALT, AST)
Frequency not reported: Clinical hepatitis/hepatitis[Ref]
There were rare cases of clinical hepatitis that were reversible with discontinuation of this drug.[Ref]
Postmarketing reports: Purpura[Ref]
Frequency not reported: Gynecomastia[Ref]
More about Cardizem CD (diltiazem)
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Reviews (2)
- Drug images
- Pricing & coupons
- Generic availability
- Drug class: calcium channel blocking agents
Related treatment guides
1. "Product Information. Cardizem (diltiazem)." Hoechst Marion-Roussel Inc, Kansas City, MO.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Dilacor XR (diltiazem)." Aventis Pharmaceuticals, Bridgewater, NJ.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.