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Diltiazem use while Breastfeeding

Drugs containing Diltiazem: Cardizem, Cartia XT, Cardizem CD, Dilt-XR, Tiazac, Matzim LA, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride CD, Tiadylt ER, Diltia XT, Show all 19 »Diltiazem Hydrochloride XR, Taztia XT, Dilacor XR, Cardizem LA, Cardizem SR, Cardizem Monovial, Diltiazem Hydrochloride XT, Diltzac, Teczem

Medically reviewed by Last updated on Aug 2, 2020.

Diltiazem Levels and Effects while Breastfeeding

Summary of Use during Lactation

Based on limited data, amounts of diltiazem ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Maternal Levels. In one patient who was 14 days postpartum, peak milk levels of 190 to 230 mcg/L occurred about 2 hours after the dose during an oral regimen of 60 mg four times daily. The levels and time course of the drug in milk closely paralleled serum levels.[1] Using the peak milk level data from this patient, an exclusively breastfed infant would receive an estimated maximum of 0.9% of the maternal weight-adjusted dosage.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Nifedipine, Verapamil


Okada M, Inoue H, Nakamura Y et al. Excretion of diltiazem in human milk. N Engl J Med. 1985;312:992-3. [PubMed: 3974691]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Antiarrhythmics
  • Vasodilator Agents

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Further information

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