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Diltiazem Pregnancy and Breastfeeding Warnings

Diltiazem is also known as: Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, Cartia XT, Dilacor XR, Dilt-XR, Diltia XT, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Diltzac, Matzim LA, Taztia XT, Tiazac

Diltiazem Pregnancy Warnings

This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk (AU, US) Use is contraindicated (UK) AU TGA pregnancy category: C US FDA pregnancy category: C Comments: -The possibility of pregnancy should be ruled out prior to starting treatment. -Women of childbearing potential should be advised to avoid becoming pregnant while receiving this medication, and should use of adequate methods of contraception throughout treatment. -Newborns exposed to this drug should be monitored for hypoxia, especially in the event of maternal hypotension.

Animal studies have revealed evidence of embryolethality, teratogenicity, and fetolethality (e.g., skeletal/heart/retina/tongue abnormalities, increased stillbirths, prolonged deliver, as well as lower pup weights and survival rates). This drug may result in decreased contraction of the uterus and decreased uterine perfusion due to peripheral vasodilation. There are no controlled data in human pregnancy. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

See references

Diltiazem Breastfeeding Warnings

This drug is freely diffusible in milk, with concentrations in breast milk that may approximate serum levels.

Use is contraindicated (AU, UK) Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother (US) Excreted into human milk: Yes Comments: The effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. "Product Information. Dilacor XR (diltiazem)." Aventis Pharmaceuticals, Bridgewater, NJ.
  4. "Product Information. Cardizem (diltiazem)." Hoechst Marion-Roussel Inc, Kansas City, MO.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL:" ([cited 2013 -]):
  2. "Product Information. Dilacor XR (diltiazem)." Aventis Pharmaceuticals, Bridgewater, NJ.
  3. "Product Information. Cardizem (diltiazem)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  4. Cerner Multum, Inc. "Australian Product Information." O 0
  5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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