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Cardene IV Side Effects

Generic name: nicardipine

Medically reviewed by Last updated on Feb 3, 2024.

Note: This document contains side effect information about nicardipine. Some dosage forms listed on this page may not apply to the brand name Cardene IV.

Applies to nicardipine: oral capsule. Other dosage forms:

Serious side effects of Cardene IV

Along with its needed effects, nicardipine (the active ingredient contained in Cardene IV) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nicardipine:

More common

Less common


Get emergency help immediately if any of the following symptoms of overdose occur while taking nicardipine:

Symptoms of overdose

Other side effects of Cardene IV

Some side effects of nicardipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to nicardipine: compounding powder, intravenous solution, oral capsule, oral capsule extended release.


The most common adverse reactions were consequences of vasodilation.[Ref]


Common (1% to 10%): Hypotension, tachycardia, flushing, angina increased, palpitations, vasodilatation

Uncommon (0.1% to 1%): Sustained tachycardia, abnormal ECG, postural hypotension, myocardial infarct

Frequency not reported: Angina pectoris, atrioventricular block, ST segment depression, inverted T wave, deep vein thrombophlebitis, sinus node dysfunction, atrial fibrillation, exertional hypotension, pericarditis, heart block, ventricular tachycardia, peripheral vascular disorder, ventricular extrasystoles[Ref]

Nervous system

Very common (10% or more): Headache (up to 21%)

Common (1% to 10%): Dizziness, somnolence, paresthesia

Uncommon (0.1% to 1%): Syncope, tremor

Frequency not reported: Confusion, hypertonia, tinnitus, cerebral ischemia, vertigo, hyperkinesia[Ref]


Common (1% to 10%): Nausea/vomiting, nausea, dyspepsia, dry mouth

Uncommon (0.1% to 1%): Constipation, vomiting, diarrhea

Frequency not reported: Sore throat[Ref]


Common (1% to 10%): Asthenia, other edema

Uncommon (0.1% to 1%): Malaise, pain, chest pain, face edema

Frequency not reported: Fever, ear disorder, atypical chest pain, hot flashes[Ref]


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Sweating increased[Ref]


Common (1% to 10%): Pedal edema

Frequency not reported: Hypophosphatemia, peripheral edema[Ref]


Common (1% to 10%): Myalgia

Frequency not reported: Neck pain, arthralgia[Ref]


Uncommon (0.1% to 1%): Nervousness, insomnia, abnormal dreams

Frequency not reported: Depression, anxiety[Ref]


Uncommon (0.1% to 1%): Nocturia, urinary frequency increased

Frequency not reported: Urinary frequency, impotence[Ref]


Uncommon (0.1% to 1%): Dyspnea

Frequency not reported: Respiratory disorder, decreased oxygen saturation, rhinitis, sinusitis[Ref]


Uncommon (0.1% to 1%): Vision blurred

Frequency not reported: Conjunctivitis, vision abnormal[Ref]


Frequency not reported: Infection, allergic reaction[Ref]


Frequency not reported: Thrombocytopenia[Ref]


Frequency not reported: Abnormal liver chemistries[Ref]


1. (2002) "Product Information. Cardene (nicardipine)." Syntex Laboratories Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.