Bendroflumethiazide / Nadolol Side Effects

Medically reviewed by Drugs.com. Last updated on May 10, 2024.

Applies to bendroflumethiazide / nadolol: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause or worsen heart failure in some patients. Check with your doctor right away if you have chest pain or discomfort, dilated neck veins, irregular breathing, an irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, weight gain, or unusual tiredness or weakness.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Do not interrupt or Stop taking bendroflumethiazide/nadolol without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

Check with your doctor right away if you start having dry mouth, increased thirst, muscle cramps, nausea or vomiting, unusual tiredness or weakness, severe drowsiness or dizziness, seizures, a decrease in urine, or a fast heartbeat while you are using this medicine. These may be symptoms of dehydration or mineral imbalance.

Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.

Serious side effects

Along with its needed effects, bendroflumethiazide / nadolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bendroflumethiazide / nadolol:

Get emergency help immediately if any of the following symptoms of overdose occur while taking bendroflumethiazide / nadolol:

Symptoms of overdose

• change in consciousness
• decreased urination
• diarrhea
• fast, slow, or shallow breathing
• gas
• heartburn
• increase in heart rate
• increased sweating
• indigestion
• loss of consciousness
• low blood pressure
• muscle cramps
• numbness, tingling, pain, or weakness in the hands or feet
• pale or blue lips, fingernails, or skin
• seizures
• sunken eyes
• trembling
• unusual drowsiness, dullness, or feeling of sluggishness
• unusual paleness
• weakness and heaviness of the legs
• wrinkled skin

Other side effects

Some side effects of bendroflumethiazide / nadolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to bendroflumethiazide / nadolol: oral tablet.

Cardiovascular adverse events

Bendroflumethiazide:

• Frequency not reported: Necrotizing angiitis, vasculitis, orthostatic hypotension

Nadolol:

• Common (1% to 10%): Heart rate less than 40 beats per minute (bpm), symptoms of peripheral vascular insufficiency, cardiac failure, hypotension, rhythm/conduction disturbances
• Frequency not reported: Heart rate less than 60 bpm, first degree heart block, third degree heart block^[Ref]

Nervous system

Bendroflumethiazide:

• Frequency not reported: Dizziness, vertigo, paresthesia, headache

Nadolol:

• Common (1% to 10%): Dizziness/fatigue
• Uncommon (0.1% to 1%): Paresthesias, sedation, headache, tinnitus, slurred speech^[Ref]

Gastrointestinal

Bendroflumethiazide:

• Frequency not reported: Nausea, vomiting, cramping, diarrhea, constipation, gastric irritation, abdominal bloating, sialadenitis, pancreatitis

Nadolol:

• Uncommon (0.1% to 1%): Nausea, diarrhea, abdominal discomfort, constipation, vomiting, indigestion, bloating, flatulence, dry mouth^[Ref]

Dermatologic

Bendroflumethiazide:

• Frequency not reported: Purpura, exfoliative dermatitis, pruritus, ecchymosis, urticaria, cutaneous vasculitis, photosensitivity, rash

Nadolol:

• Uncommon (0.1% to 1%): Rash, pruritus, dry skin, sweating, facial swelling
• Frequency not reported: Reversible alopecia^[Ref]

Respiratory

Bendroflumethiazide:

• Frequency not reported: Respiratory distress, pneumonitis

Nadolol:

• Uncommon (0.1% to 1%): Bronchospasm, cough, nasal stuffiness^[Ref]

Metabolic

Bendroflumethiazide:

• Frequency not reported: Anorexia, hyperglycemia, metabolic acidosis, hyperuricemia

Nadolol:

• Uncommon (0.1% to 1%): Anorexia, weight gain^[Ref]

Ocular

Bendroflumethiazide:

• Frequency not reported: Xanthopsia, transient blurred vision

Nadolol:

• Uncommon (0.1% to 1%): Dry eyes, blurred vision^[Ref]

Psychiatric

Bendroflumethiazide:

• Frequency not reported: Restlessness

Nadolol:

• Uncommon (0.1% to 1%): Change in behavior, impotence or decreased libido^[Ref]

Hematologic

Bendroflumethiazide:

• Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia^[Ref]

Hepatic

Bendroflumethiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice, hepatitis^[Ref]

Immunologic

Bendroflumethiazide:

• Frequency not reported: Anaphylactic reactions, allergic glomerulonephritis^[Ref]

Other

Bendroflumethiazide:

• Frequency not reported: Fever, weakness^[Ref]

Genitourinary

Bendroflumethiazide:

• Frequency not reported: Glycosuria^[Ref]

Musculoskeletal

Bendroflumethiazide:

• Frequency not reported: Muscle spasm^[Ref]

See also:

Further information

Bendroflumethiazide/nadolol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer