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Azelastine / fluticasone nasal Side Effects

For the Consumer

Applies to azelastine / fluticasone nasal: nasal spray

Along with its needed effects, azelastine / fluticasone nasal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking azelastine / fluticasone nasal:

Less common
  • Bloody nose
  • body aches or pain
  • chills
  • cold or flu-like symptoms
  • congestion
  • cough or hoarseness
  • difficulty with breathing
  • dryness or soreness of the throat
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • tender, swollen glands in the neck
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes
Incidence not known
  • Blindness
  • bloody mucus or unexplained nosebleeds
  • blurred vision
  • chest pain
  • darkening of the skin
  • decreased vision
  • delayed wound healing
  • diarrhea
  • difficult or labored breathing
  • dizziness
  • eye pain
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • hives, itching, or skin rash
  • lack or slowing of normal growth in children
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • mental depression
  • nausea or vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sleepiness or unusual drowsiness
  • sore mouth or tongue
  • sores inside the nose
  • tearing
  • tightness in the chest
  • white patches in the mouth or on the tongue

Some side effects of azelastine / fluticasone nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Change in taste
  • loss of taste
Incidence not known
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • change in sense of smell
  • changes in vision
  • discharge or excessive tearing
  • hives or welts
  • irritation at the application site
  • loss of smell
  • mental or mood changes
  • redness of the skin
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

For Healthcare Professionals

Applies to azelastine / fluticasone nasal: nasal spray


The most commonly reported side effects were headache, pyrexia, cough, nasal congestion, and rhinitis.[Ref]


Postmarketing reports: Hypersensitivity reactions (including angioedema, skin rash, edema of the face and tongue, pruritus, urticaria, bronchospasm, wheezing, dyspnea, and anaphylaxis/anaphylactoid reactions)[Ref]


Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis effects[Ref]


Common (1% to 10%): Viral infection

Frequency not reported: Immunosuppression, Candida albicans infection[Ref]


Common (1% to 10%): Epistaxis, cough, nasal congestion, rhinitis, upper respiratory tract infection, pharyngitis

Postmarketing reports: Nasal sores

Rare (0.01% than 0.1%): Nasal septal perforation, nasal ulcer, sore throat, throat irritation and dryness, cough, hoarseness, voice changes[Ref]

Nervous system

Common (1% to 10%) Dysgeusia, headache
Uncommon (0.1% to 1%): Somnolence

Postmarketing reports: Confusion, involuntary muscle contractions, paraesthesia, parosmia, disturbance or loss of sense of smell and/or taste[Ref]


Postmarketing reports: Abnormal vision, xerophthalmia

Postmarketing reports: Dryness, irritation, conjunctivitis, blurred vision, glaucoma, increased intraocular pressure, cataracts[Ref]


Common (1% to 10%): Diarrhea
Rare (0.01% than 0.1%): Dry mouth
Very rare (less than 0.01%): Nausea[Ref]


Common (1% to 10%): Pyrexia, pain
Very rare (less than 0.01%): Fatigue

Frequency not reported: Impaired wound healing[Ref]


Postmarketing reports: Atrial fibrillation, chest pain, palpitations[Ref]


Postmarketing reports: Application site irritation[Ref]


Postmarketing reports: Urinary retention[Ref]


Postmarketing reports: Growth suppression[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Dymista (azelastine-fluticasone nasal)." Meda Pharmaceuticals, Somerset, NJ.

Some side effects of azelastine / fluticasone nasal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.