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Azelastine and fluticasone nasal

Generic name: azelastine and fluticasone nasal [ AY-zel-AS-teen-and-floo-TIK-a-sone ]
Brand name: Dymista
Dosage form: nasal spray (137 mcg-50 mcg/inh)
Drug classes: Nasal antihistamines and decongestants, Nasal steroids

Medically reviewed by on Oct 27, 2022. Written by Cerner Multum.

What is azelastine and fluticasone nasal?

Azelastine and fluticasone nasal (for the nose) is a combination antihistamine and steroid medication used to treat sneezing, runny or stuffy nose, itching, and other nasal symptoms of allergies. azelastine and fluticasone nasal is for use in adults and children who are at least 6 years old.

Azelastine and fluticasone nasal may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Tell your doctor if you have ever had:

It is not known whether azelastine and fluticasone nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Using azelastine and fluticasone nasal while you are breast-feeding may cause your breast milk to taste bitter. If you breast-feed while using this medicine, watch for signs that your baby is not nursing as well. Talk to your doctor about the best way to feed your baby.

How should I use azelastine and fluticasone nasal?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Shake the medicine bottle gently just before each use.

Avoid getting this medicine in your eyes or mouth.

If the medicine gets in your eyes, rinse with water for 10 minutes and then call your doctor.

Do not allow a young child to use this medicine without help from an adult.

Store this medicine in an upright position at room temperature. Do not freeze or refrigerate.

Throw away the medicine after you have used 120 sprays, even if there is still medicine left in the bottle.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

An overdose of azelastine and fluticasone nasal is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Using too much of azelastine and fluticasone nasal long term can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using azelastine and fluticasone nasal?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol with this medicine can increase certain side effects.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using azelastine and fluticasone nasal.

Azelastine and fluticasone nasal side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

The medicine may cause serious side effects. Stop using the medicine and call your doctor at once if you have:

  • severe drowsiness;

  • severe or ongoing nosebleeds;

  • noisy breathing, runny nose, or crusting around your nostrils;

  • redness, sores, or white patches in your mouth or throat;

  • fever, chills, tiredness, body aches;

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;

  • any wound that will not heal; or

  • signs of low adrenal gland hormones--worsening tiredness or weakness, feeling light-headed, nausea, vomiting.

Steroid medicine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using azelastine and fluticasone nasal.

Common side effects of azelastine and fluticasone nasal may include:

  • headache;

  • nosebleeds; or

  • altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Azelastine and fluticasone nasal dosing information

Usual Adult Dose for Allergic Rhinitis:

1 spray in each nostril twice a day

Uses: Relief of symptoms of seasonal allergic rhinitis

Usual Pediatric Dose for Allergic Rhinitis:

6 years and older:
1 spray in each nostril twice a day

Uses: Relief of symptoms of seasonal allergic rhinitis

What other drugs will affect azelastine and fluticasone nasal?

Using azelastine and fluticasone nasal with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect azelastine and fluticasone nasal, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.