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Axsain Side Effects

Generic Name: capsaicin topical

Note: This document contains side effect information about capsaicin topical. Some of the dosage forms listed on this page may not apply to the brand name Axsain.

For the Consumer

Applies to capsaicin topical: topical cream, topical film, topical gel/jelly, topical liquid, topical lotion, topical ointment, topical pad, topical patch extended release, topical solution, topical stick

Along with its needed effects, capsaicin topical (the active ingredient contained in Axsain) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking capsaicin topical:

More common - all forms

  • Burning, itching, dryness, pain, redness, swelling, or soreness at the application site

Less common - all forms

  • Cough
  • cough-producing mucus
  • difficulty with breathing
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • tightness in the chest or wheezing

Less common - patch only

Incidence not known - patch only

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • increased sensitivity to pain
  • increased sensitivity to touch
  • rapid weight gain
  • tingling in the hands and feet
  • unsteadiness or awkwardness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet

Some side effects of capsaicin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common - patch only

  • Fever
  • muscle aches
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • unusual tiredness or weakness
  • vomiting

Incidence not known - patch only

  • Abnormal skin color
  • change in taste
  • loss of taste

For Healthcare Professionals

Applies to capsaicin topical: compounding powder, topical cream, topical film, topical gel, topical kit, topical liquid, topical lotion, topical stick

General

The most commonly reported side effects were application site erythema and application site pain.[Ref]

Local

Very common (10% or more): Application site erythema (63%), application site pain (42%)

Common (1% to 10%): Application site pruritus, application site papules, application site edema, application site swelling, application site dryness

Uncommon (0.1% to 1%): Application site urticaria, application site paresthesia, application site dermatitis, application site hyperesthesia, application site excoriation, application site warmth, application site anesthesia, application site bruising, application site inflammation, application site exfoliation[Ref]

Cardiovascular

Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): First degree atrio-ventricular (AV) block, tachycardia, palpitations, increased blood pressure[Ref]

Dermatologic

Uncommon (0.1% to 1%): Herpes zoster, pruritus

Frequency not reported: Abnormal skin odor, second degree burns[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, bronchitis, sinusitis

Uncommon (0.1% to 1%): Cough, throat irritation

Frequency not reported: Sneezing, dyspnea, wheezing, exacerbation of asthma, irritation of the mucous membranes of the respiratory tract (such as nasal and throat irritation)[Ref]

Gastrointestinal

Common (1% to 10%): Nausea[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Pain in extremity, muscle spasms[Ref]

Nervous system

Uncommon (0.1% to 1%): Dysgeusia, hypoesthesia, burning sensation

Frequency not reported: Headache, peripheral sensory neuropathy, dizziness, dysgeusia, hyperesthesia[Ref]

Ocular

Uncommon (0.1% to 1%): Eye irritation

Frequency not reported: Irritation of the mucous membranes of the eyes, runny eyes[Ref]

Other

Frequency not reported: Peripheral edema[Ref]

References

1. "Product Information. Zostrix-HP (capsaicin topical)." Medicis Pharmaceutical Corporation, Scottsdale, AZ.

2. "Product Information. Qutenza (capsaicin topical)." NeurogesX Inc, San Mateo, CA.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

5. "Product Information. Zostrix (capsaicin topical)." Southwood Pharmaceuticals Inc, Lake Forest, CA.

6. "Product Information. Axsain (capsaicin topical)." Rodlen Laboratories, Vernon Hills, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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